A5086103903- Environmental Toxicology and Ecotoxicology
- Toxic Organic Pollutants Impact
- Effects and risks of endocrine disrupting chemicals
- Aquatic Ecosystems and Phytoplankton Dynamics
- Pharmaceutical and Antibiotic Environmental Impacts
- Biocrusts and Microbial Ecology
- Retinoids in leukemia and cellular processes
- Air Quality and Health Impacts
- Marine and coastal ecosystems
- Environmental Science and Water Management
- bioluminescence and chemiluminescence research
- Reproductive biology and impacts on aquatic species
- Carcinogens and Genotoxicity Assessment
- Estrogen and related hormone effects
- Analytical chemistry methods development
- Pesticide and Herbicide Environmental Studies
- Aquatic Ecosystems and Biodiversity
- Microbial bioremediation and biosurfactants
- Algal biology and biofuel production
- Antioxidant Activity and Oxidative Stress
- Marine and environmental studies
- Heavy metals in environment
- Per- and polyfluoroalkyl substances research
- Heavy Metal Exposure and Toxicity
- Pesticide Residue Analysis and Safety
Masaryk University
2016-2025
RECETOX
2010-2019
Czech Academy of Sciences
2006-2010
Czech Academy of Sciences, Institute of Botany
2006-2009
University of Veterinary Sciences Brno
2008
Michigan State University
2000-2006
City University of Hong Kong
2005
New York State Department of Health
2003
Wadsworth Center
2003
National Institute of Advanced Industrial Science and Technology
2003
Thousands of organic micropollutants and their transformation products occur in water. Although often present at low concentrations, individual compounds contribute to mixture effects. Cell-based bioassays that target health-relevant biological endpoints may therefore complement chemical analysis for water quality assessment. The objective this study was evaluate cell-based suitability benchmark assess efficacy treatment processes. selected cover relevant steps the toxicity pathways...
Environmental water quality monitoring aims to provide the data required for safeguarding environment against adverse biological effects from multiple chemical contamination arising anthropogenic diffuse emissions and point sources. Here, we integrate experience of international EU-funded project SOLUTIONS shift focus a few legacy chemicals complex mixtures, identify relevant drivers toxic effects. Monitoring serves range purposes, control ecological status compliance specific uses, such as...
The present monitoring and assessment of the chemical status water bodies fail to characterize likelihood that complex mixtures chemicals affect quality. European Collaborative Project SOLUTIONS suggests this can be estimated with effect-based methods (EBMs) complemented by screening and/or impact modeling. These should used identify causes impacted quality develop programs measures improve Along line reasoning, are recommended for Water Framework Directive (WFD) cover major modes action in...
Surface water can contain countless organic micropollutants, and targeted chemical analysis alone may only detect a small fraction of the chemicals present. Consequently, bioanalytical tools be applied complementary to effects complex mixtures. In this study, bioassays indicative activation aryl hydrocarbon receptor (AhR), pregnane X (PXR), estrogen (ER), adaptive stress responses oxidative (Nrf2), genotoxicity (p53) inflammation (NF-κB) fish embryo toxicity test were along with extracts...
The potential for a variety of environmental contaminants to disturb endocrine function in wildlife and humans has been recent concern. While much effort is being focused on the assessment effects mediated through steroid hormone receptor–based mechanisms, there are potentially several other mechanisms that could lead disruption. Recent studies have demonstrated xenobiotics can alter gene expression or activity enzymes involved steroidogenesis. By altering production catalytic steroidogenic...
Chemicals in the environment occur mixtures rather than as individual entities. Environmental quality monitoring thus faces challenge to comprehensively assess a multitude of contaminants and potential adverse effects. Effect-based methods have been suggested complements chemical analytical characterisation complex pollution patterns. The regularly observed discrepancy between biological assessments effects due field may be either unidentified or result from interactions compounds mixtures....
Cyanobacterial blooms occur with increasing frequency in freshwater ecosystems, posing a hazard to human and environmental health. Exposure of cyanobacterial metabolites occurs mostly via accidental ingestion through contaminated drinking water or during recreational activities and, most frequently, results gastrointestinal symptoms. Despite the clinical manifestation, are rather investigated for their toxicity towards specific organs tissues, especially hepato-, nephro-, neurotoxicity, than...
The fate and effects of cytostatic (anticancer or antineoplastic) pharmaceuticals in the environment are largely unknown, but they can contaminate wastewater treatment effluents consequently aquatic ecosystems. In this paper, we have focused on five compounds used high amounts (cyclophosphamide, cisplatin, 5-fluorouracil, doxorubicin, etoposide), investigated their ecotoxicity bacterial Pseudomonas putida growth-inhibition test, algal Pseudokirchneriella subcapitata Dapnia magna acute...
Abstract N ‐heterocyclic derivatives of polycyclic aromatic hydrocarbons (NPAHs) are widespread concomitantly with their parent analogues and have been detected in air, water, sediments, soil. Although they were shown to be highly toxic some organisms, our understanding occurrence, environmental fate, biological metabolism, effects is limited. This study evaluated three homocyclic (PAHs—phenanthrene, anthracene, fluorene) seven derivates on higher terrestrial plants Sinapis alba, Triticum...