A5052790406- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Nail Diseases and Treatments
- Antimicrobial Peptides and Activities
- T-cell and Retrovirus Studies
- Plant-Microbe Interactions and Immunity
- Infectious Diseases and Mycology
- Erythrocyte Function and Pathophysiology
- T-cell and B-cell Immunology
- Peptidase Inhibition and Analysis
- Plant Pathogens and Fungal Diseases
- Acoustic Wave Resonator Technologies
- Yeasts and Rust Fungi Studies
- Enzyme Production and Characterization
- Immune Cell Function and Interaction
- Toxin Mechanisms and Immunotoxins
- Tannin, Tannase and Anticancer Activities
- Galectins and Cancer Biology
- Cytomegalovirus and herpesvirus research
University of British Columbia
2024-2025
British Columbia Children's Hospital
2025
Universidade de São Paulo
2014-2024
Canada's Michael Smith Genome Sciences Centre
2024
British Academy
2024
Albert Einstein College of Medicine
2021-2023
Fundação de Apoio à Escola Técnica
2014
Instituto do Coração
2014
Celula (United States)
2014
Fundação Faculdade de Medicina
2014
There is an urgent need for new antifungal drugs to treat invasive fungal diseases. Unfortunately, the echinocandin that are fungicidal against other important pathogens ineffective
Paracoccidioidomycosis (PCM) is a granulomatous fungal disease caused by the dimorphic species of Paracoccidioides, which mainly affects lungs. Modern strategies for treatment and/or prevention PCM are based on Th1-type immune response, important controlling disease. One most studied candidates vaccine P10 peptide, derived from 43 kDa glycoprotein Paracoccidioides brasiliensis. In order to improve its modulatory effect, peptide was associated with chitosan-conjugated nanoparticle. The...
Abstract Monogenic defects that impair the control of inflammation and tolerance lead to profound immune dysregulation, including autoimmunity atopy. Studying these disorders reveals important molecular cellular factors regulate human homeostasis identifies potential precision medicine targets. Here, we provide a detailed immunological assessment pediatric patient with recently discovered syndrome causing Immunodysregulation, Craniofacial anomalies, Hearing impairment, Athelia, Developmental...
Paracoccidioidomycosis (PCM) is an endemic systemic mycosis in Latin America, with the highest prevalence Brazil, Colombia and Venezuela. Fungi of Paracoccidioides genus are etiologic agents disease. The 15 amino acid peptide P10 derived from gp43, main diagnostic antigen P. brasiliensis. We previously reported that P10-pulsed dendritic cells (DCs) induce a protective response against Presently, dexamethasone-treated BALB/c mice were intratracheally infected brasiliensis Pb18 to establish...
Tannase is an extracellular inducible enzyme of great biotechnological interest. The microorganisms such as species from the Aspergillus and Penicillium genus are the most important source tannase. objective this study was to isolate, identify and select strains filamentous fungi present in caves located Brazilian biome for tannase production. Five hundred forty-four fungal were isolated three eighty-six had ability grow plates containing tannic acid medium sole carbon source. A total 32...
Paracoccidioidomycosis (PCM), a systemic mycosis prevalent in Latin America, is caused by the thermodymorphic fungi of genus Paracoccidioides spp. Notably, Th1 immune response required to control PCM. In this context, dendritic cells (DCs) seem be essential players capture, processing and presentation antigens naïve T their further activation. We have previously demonstrated that differentiated DCs from bone marrow (BMDCs), pulsed with immunoprotective peptide 10 (P10), effectively...
Paracoccidioidomycosis (PCM) is an endemic mycosis in Latin America caused by the thermodimorphic fungi of genus Paracoccidioides spp. lutzii (PL) one 5 species that constitute genus. PL expresses low amounts glycoprotein (Gp) 43 (PLGp43) and PLGp43 displays few epitopes common with P. brasiliensis (PB) immunodominant antigen PBGp43, which commonly used for serological diagnosis PCM. This difference structure between glycoproteins markedly reduces efficiency patients infected PL. We...
Background: Paracoccidioidomycosis (PCM) is a chronic disease that causes sequelae and requires prolonged treatment; therefore, new therapeutic approaches are necessary. In view of this, three peptides from Paracoccidioides brasiliensis 14-3-3 protein were selected based on its immunogenicity potential. Methods: The in vitro antifungal activity cytotoxicity the evaluated. influence immunological survival aspects was evaluated vivo, using Galleria mellonella expression antimicrobial peptide...
Paracoccidioidomycosis (PCM), caused by the Paracoccidioides species, is a systemic disease endemic in several Latin American countries, mainly Brazil, Colombia, Argentina, and Venezuela. Current treatment approaches are challenging as they require prolonged durations of antifungal drugs that have potential toxicities, despite antifungals, relapses common. Hence, new therapeutic approaches, such vaccines, being investigated. The vaccine consisting peptide P10 associated with lipid cationic...
Paracoccidioidomycosis (PCM) is a granulomatous systemic mycosis caused by the thermo-dimorphic fungi of genus Paracoccidioides. Melanin production can affect their pathogenesis and virulence. This study evaluates melanin different isolates Paracoccidioides examines how presence this polymer affects yeast cell phagocytosis, as well laccase enzyme production. The results obtained showed that Paracoccidioides: P. lutzii (Pb01, Pb66, ED01, Pb1578, Pb8334), restrepiensis (PS3-Pb60855),...
Background Auranofin is an approved anti-rheumatic drug that has a broad-range inhibitory action against several microorganisms, including human pathogenic fungi. The auranofin activity Histoplasma capsulatum , the dimorphic fungus causes histoplasmosis, not been properly addressed. Since there are few therapeutic options for this life-threatening systemic mycosis, study evaluated effects of on H . growth and expression virulence factors. Methodology/principal findings Minimal fungicidal...
Paracoccidioidomycosis (PCM) may present as an acute/subacute clinical form, characterized by a progressive disease arising from the airborne initial infection, or, most often, asymptomatic or subclinical infection that manifest later during individual's life, chronic form. Epidemiological studies show existence of strong association between smoking and development Current evidence demonstrates cigarette smoke (CS) has immunosuppressive properties could be implicated in increasing...
Pathogens must overcome the hostile conditions of their hosts to survive, proliferate and cause disease. The fungal pathogen Cryptococcus neoformans is particularly adept at mitigating challenges in host environment has developed an arsenal defense mechanisms evade oxidative nitrosative agents released by phagocytic cells during infection. Among these mechanisms, melanin production crucially linked both virulence against harmful free radicals that facilitate innate immunity clearance...
Heat shock proteins (Hsps) are highly conserved molecules that constitutively expressed and upregulated in response to physiological stress conditions. These immunogenic chaperones can have essential functions fungi, particularly dimorphic pathogens. Histoplasma capsulatum Paracoccidioides species fungi the causative agents of histoplasmosis paracoccidioidomycosis, respectively, which systemic mycoses with significant rates morbidity mortality. Current treatment consists long-term antifungal...