A5011438561- Pneumonia and Respiratory Infections
- Heart Failure Treatment and Management
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac Valve Diseases and Treatments
- Coronary Interventions and Diagnostics
- Cardiac Structural Anomalies and Repair
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Atherosclerosis and Cardiovascular Diseases
- Sepsis Diagnosis and Treatment
- Congenital Heart Disease Studies
- Cardiac tumors and thrombi
- Cardiovascular Effects of Exercise
- Nosocomial Infections in ICU
- Blood Pressure and Hypertension Studies
- Cardiac Ischemia and Reperfusion
- Advanced MRI Techniques and Applications
- Venous Thromboembolism Diagnosis and Management
- Adipokines, Inflammation, and Metabolic Diseases
Sapienza University of Rome
2015-2024
Bambino Gesù Children's Hospital
2018-2024
Policlinico Umberto I
2019-2022
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2022
ERN GUARD-Heart
2021
IRCCS Policlinico San Donato
2016
Università Cattolica del Sacro Cuore
2015
Istituto Neurologico Mediterraneo
2013
Rutgers, The State University of New Jersey
2013
Rutgers New Jersey Medical School
2013
Abstract Ischaemic heart disease represents the leading cause of morbidity and mortality, typically induced by detrimental effects risk factors on cardiovascular system. Although preventive interventions tackling conventional have helped to reduce incidence ischaemic disease, it remains a major death worldwide. Thus, attention is now shifting non-traditional in built, natural, social environments that collectively contribute substantially burden perpetuate residual risk. Of importance, these...
Abstract Aims Low-grade endotoxaemia is detectable in human circulation but its role thrombosis still unclear. Methods and results We measured serum lipopolysaccharide (LPS) concentration, soluble P-selectin (sP-selectin), a marker of platelet activation, zonulin, gut permeability, peripheral circulation, coronary thrombi, intracoronary blood patients with ST-elevation myocardial infarction (STEMI, n = 50) stable angina (SA) (n 50), respectively, controls 50). Experimental study was carried...
Pneumonia is complicated by high rate of mortality and cardiovascular events (CVEs). The potential benefit aspirin, which lowers platelet aggregation inhibition thromboxane A2 production, still unclear. aim the study was to assess impact aspirin on in patients with pneumonia.Consecutive admitted University-Hospital Policlinico Umberto I (Rome, Italy) community-onset pneumonia were recruited prospectively followed up until discharge or death. primary end point occurrence death 30 days after...
The effect of lipopolysaccharide (LPS) on platelet aggregation is still controversial. We performed in vitro and ex vivo studies controls patients with community-acquired pneumonia (CAP) to assess the LPS activation (PA). (15-100 pg/ml) significantly increased PA only if combined sub-threshold concentrations (STC) collagen or ADP; this was associated H2O2 production, Nox2 activation, PLA2 phosphorylation, thromboxane (Tx)A2 8-iso-PGF2α-III, inhibited by aspirin, TxA2 receptor antagonist...
Adults hospitalized for community-acquired pneumonia (CAP) have an increased risk of myocardial infarction. Corticosteroid treatment lowers CAP morbidity and mortality, but it is not known whether influences in-hospital infarction.The aim the present study was to investigate potential interplay between corticosteroid infarction in adults with CAP.We retrospectively analyzed referred University Hospital Policlinico Umberto I (Rome, Italy), consecutively recruited, prospectively followed until...
<h3>Background</h3> Community-acquired pneumonia (CAP) may be complicated by atrial fibrillation (AF) but the underlying mechanism is still unclear. Nox2-derived oxidative stress has been suggested to favour AF. <h3>Methods</h3> We consecutively enrolled 432 patients hospitalised for CAP. Nox2 activity, as assessed serum levels of soluble (sNox2-dp), was evaluated in each CAP patient. A 12-lead electrocardiography repeated every 24 h. All were followed up until discharge. <h3>Results</h3>...
ABSTRACT Background and objective Community‐acquired pneumonia ( CAP ) is associated with an increased risk of arterial venous thrombosis but the underlying pathophysiological mechanisms are still unclear. We investigated if, in patients , a pro‐thrombotic state does exist its relationship serum levels endotoxins. Methods A total 104 consecutive were prospectively recruited followed up until discharge. At admission at discharge, endotoxins, systemic markers clotting activation zonulin,...
Abstract Background It is still unclear if patients with community-acquired pneumonia (CAP) and coronavirus disease 2019 (COVID-19) have different rate, typology, impact of thrombosis on survival. Methods In this multicenter observational cohort study, 1,138 patients, hospitalized for CAP (n = 559) or COVID-19 579) from seven clinical centers in Italy, were included the study. Consecutive adult (age ≥ 18 years) confirmed COVID-19-related pneumonia, without mechanical ventilation, March 1,...
NOX2, the catalytic subunit of NADPH oxidase, is suggested to play a role in favouring occurrence atrial fibrillation (AF) after cardiac surgery via formation reactive oxidant species. However, its spontaneous AF still unclear.To define NOX2 and isoprostanes, marker oxidative stress, different settings AF.The study was performed on 174 patients with (82 paroxysmal/persistent 92 permanent AF) 90 controls matched for sex, age atherosclerotic risk factors. Urinary isoprostanes serum levels...
C2238 atrial natriuretic peptide (ANP) minor allele (substitution of thymidine with cytosine in position 2238) associates increased risk cardiovascular events.We investigated the mechanisms underlying vascular effects C2238-αANP.In vitro, human umbilical vein endothelial cell were exposed to either wild-type (T2238)- or mutant (C2238)-αANP. Cell survival and apoptosis tested by Trypan blue, annexin V, cleaved caspase-3 assays. C2238-αANP significantly reduced apoptosis. In addition, tube...
The role of allergic inflammation in acute coronary syndromes (ACS) has not been clearly defined to date. Aim this study was assess eosinophil and basophil activation ACS the prognostic cationic protein ST-segment-elevation myocardial infarction.In a cross-sectional study, we prospectively enrolled 51 patients undergoing percutaneous intervention (60.8% with 39.2% stable angina). Flow cytometry analysis assessed CD66b, CD69, CD203c median fluorescence intensity expression. In follow-up 181...
In the present study, we tested hypothesis that oxidative stress could be implicated in myocardial damage during acute phase of pneumonia. NOX2 activation, catalytic subunit NADPH oxidase, and high-sensitivity cardiac troponin T (hs-cTnT) elevation have been analyzed two hundred forty-eight consecutive patients hospitalized for community-acquired Serum NOX2-derived peptide (sNOX2-dp), a marker 8-isoprostaglandin F2α (8-iso-PGF2α), stress, were measured upon admission; serum hs-cTnT ECG every...