A5056427455- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- biodegradable polymer synthesis and properties
- Hydrogels: synthesis, properties, applications
- Graphene and Nanomaterials Applications
- 3D Printing in Biomedical Research
- Silk-based biomaterials and applications
- Nanofabrication and Lithography Techniques
- Nanotechnology research and applications
- Nanoparticle-Based Drug Delivery
- Advanced Polymer Synthesis and Characterization
- Advanced biosensing and bioanalysis techniques
- Polymer Nanocomposites and Properties
- Mesenchymal stem cell research
- Polymer crystallization and properties
- Osteoarthritis Treatment and Mechanisms
- Force Microscopy Techniques and Applications
- Additive Manufacturing and 3D Printing Technologies
- Bone and Dental Protein Studies
- Supramolecular Self-Assembly in Materials
- Periodontal Regeneration and Treatments
- Tissue Engineering and Regenerative Medicine
- Cancer Cells and Metastasis
- RNA Interference and Gene Delivery
- Polymer Surface Interaction Studies
University of South Carolina
2016-2025
University of Milano-Bicocca
2018
The University of Texas Health Science Center at Houston
2018
University of California, San Diego
2018
University of Cincinnati
2018
Radboud University Nijmegen
2013
National University of Singapore
2013
Mayo Clinic
2003-2006
Amirkabir University of Technology
2000-2004
WinnMed
2004
Osteogenic differentiation and mineralization of bone marrow stromal (BMS) cells depends on the cells' interactions with bioactive peptides associated matrix proteins. The RGD ECM proteins interact BMS through integrin surface receptors to facilitate cell spreading adhesion. BMP peptide corresponding residues 73−92 morphogenetic protein-2 promotes cells. objective this work was investigate effects peptides, grafted a hydrogel substrate, osteogenic acrylamide-terminated by reacting acrylic...
The growth and expression of cancer stem cells (CSCs) depend on many factors in the tumor microenvironment. objective this work was to investigate effect cells' tissue origin optimum matrix stiffness for CSC marker a model polyethylene glycol diacrylate (PEGDA) hydrogel without interference other microenvironment.Human MCF7 MDA-MB-231 breast carcinoma, HCT116 colorectal AGS gastric U2OS osteosarcoma were used. encapsulated PEGDA gels with compressive moduli 2-70 kPa range optimized cell...
A green and simple process for preparing the polyethylene glycol passivated fluorescent carbon dots (CDs-PEG) have been studied by a microwave pyrolysis method, using gelatin PEG as starting materials. This method is very effective development of carbon-based quantum from with high yield (QY). The synthesized CDs-PEG were found to emit blue photoluminescence (PL) maximum QY 34%. At following research, we investigated effect presence on PL intensity, result showed that becomes stronger...
A novel polymer, oligo(poly(ethylene glycol) fumarate) (OPF), cross-linked with a thermal radical initiation system has recently been developed in our laboratory as an injectable, biodegradable cell carrier for regeneration of orthopaedic tissues. The cross-linking, swelling, and degradative properties hydrogels prepared from OPF poly(ethylene two different chain lengths were assessed. types had similar gelation onset times (∼3.6 min) but, when 8 min at 37 °C, exhibited significantly...
Pore interconnectivity within scaffolds is an important parameter influencing cell migration and tissue ingrowth needed to promote regeneration. Methods for assessment of are usually qualitative, restricted two-dimensional images, or destructive. Microcomputed tomography nondestructively provides three-dimensional (3D) images intact specimens at high spatial resolutions. We describe image analysis technique quantitative scaffold interconnectivity. Scaffolds were made via a particulate...
Poly(propylene fumarate) (PPF) is an injectable, biodegradable polymer that has been used for fabricating preformed scaffolds in tissue engineering applications because of situ crosslinking characteristics. Aiming understanding the effects pore structure parameters on bone ingrowth, 3-dimensional (3D) PPF with controlled architecture have produced this study from computer-aided design (CAD) models. We created original scaffold models 3 sizes (300, 600, and 900 µm) randomly closed 0%, 10%,...
Abstract Novel hydrogel materials based on oligo(poly(ethylene glycol) fumarate) (OPF) crosslinked with a redox radical initiation system were recently developed in our laboratory as injectable cell carriers for orthopedic tissue engineering applications. The effect of OPF material properties vitro osteogenic differentiation encapsulated rat marrow stromal cells (MSCs) and without the presence supplements (dexamethasone) was investigated. Two formulations that resulted hydrogels different...
Engineering bone tissue requires the generation of a highly organized vasculature. Cellular behavior is affected by respective niche. Directing cellular and differentiation for creating mineralized regions surrounded vasculature can be achieved controlling pattern osteogenic angiogenic niches. This manuscript reports on engineering vascularized tissues incorporating cell‐laden niches in photocrosslinkable hydrogel construct. Two‐step photolithography process used to control stiffness...