A5054218321- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- biodegradable polymer synthesis and properties
- Silicon Nanostructures and Photoluminescence
- Dermatology and Skin Diseases
- Synthesis and properties of polymers
- Carbon and Quantum Dots Applications
- Advanced Polymer Synthesis and Characterization
- Toxin Mechanisms and Immunotoxins
- Graphene and Nanomaterials Applications
- RNA Interference and Gene Delivery
- Electrospun Nanofibers in Biomedical Applications
- Mesoporous Materials and Catalysis
- Photopolymerization techniques and applications
- Ocular Surface and Contact Lens
- Gold and Silver Nanoparticles Synthesis and Applications
- Nanopore and Nanochannel Transport Studies
- Advancements in Photolithography Techniques
- Microencapsulation and Drying Processes
- Bone Tissue Engineering Materials
- Contact Dermatitis and Allergies
- Inhalation and Respiratory Drug Delivery
- Nanowire Synthesis and Applications
- Nanofabrication and Lithography Techniques
- Dendrimers and Hyperbranched Polymers
Leiden University
2015-2018
Centre for Human Drug Research
2015-2018
University of Eastern Finland
2008-2015
Oulu University Hospital
2015
University of Turku
2015
In this study, we investigated the potential of intradermal delivery nanoparticulate vaccines to modulate immune response protein antigen using hollow microneedles. Four types nanoparticles covering a broad range physiochemical parameters, namely poly (lactic-co-glycolic) (PLGA) nanoparticles, liposomes, mesoporous silica (MSNs) and gelatin (GNPs) were compared. The developed loaded with model (ovalbumin (OVA)) without an adjuvant (poly(I:C)), followed by characterization size, zeta...
Skin is an attractive but also very challenging immunisation site for particulate subunit vaccines. The aim of this study was to develop hyaluronan (HA)-based dissolving microneedles (MNs) loaded with PLGA nanoparticles (NPs) co-encapsulating ovalbumin (OVA) and poly(I:C) intradermal immunisation. NP:HA ratio used the preparation MNs appeared be critical quality their dissolution in ex vivo human skin. Asymmetrical flow field-flow fractionation dynamic light scattering were analyse NPs...
Porous silicon (PSi) is receiving growing attention in biomedical research, for example, drug and peptide delivery. Inspired by several advantages of PSi, herein, thermally oxidized (TOPSi, hydrophilic), undecylenic acid-treated hydrocarbonized (UnTHCPSi, moderately (THCPSi, hydrophobic) PSi nanocarriers are investigated sustained subcutaneous (sc) intravenous (iv) The route administration shown to affect drastically YY3-36 (PYY3-36) release from the mice. Subcutaneous demonstrated be...
The skin is an attractive organ for immunization due to the presence of a large number epidermal and dermal antigen-presenting cells. Hollow microneedles allow precise non-invasive intradermal delivery vaccines. In this study, ovalbumin (OVA)-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles with without TLR3 agonist poly(I:C) were prepared administered intradermally by hollow microneedles. capacity PLGA induce cytotoxic T cell response, contributing protection against intracellular...
The purpose of this study was to optimize the manufacturing dissolving microneedles (dMNs) and increase antigen loading in dMNs investigate effect on their physicochemical properties. To achieve this, a novel single-array wells polydimethylsiloxane mold designed, minimizing wastage during fabrication achieving homogeneous distribution among dMN arrays. Using mold, hyaluronan (HA)-based were fabricated tested for maximal ovalbumin (OVA) content. could be with an OVA:HA ratio as high 1:1...
To develop a new intradermal antigen delivery system by coating microneedle arrays with lipid bilayer-coated, antigen-loaded mesoporous silica nanoparticles (LB-MSN-OVA). Synthesis of MSNs 10-nm pores was performed and the were loaded model ovalbumin (OVA), coated bilayer The uptake LB-MSN-OVA bone marrow-derived dendritic cells (BDMCs) studied flow cytometry. designed onto pH-sensitive pyridine-modified into ex vivo human skin studied. synthesized demonstrated efficient loading OVA maximum...
Porous silicon (PSi) is an innovative inorganic material that has been recently developed for various drug delivery systems. For example, hydrophilic and hydrophobic PSi microparticles have utilized to improve the dissolution rate of poorly soluble drugs sustain peptide delivery. Previously, well-plate method demonstrated be a suitable in vitro particles but it was not applicable wetting thermally hydrocarbonized (THCPSi) particles. In this work, three different techniques, namely...