A5079373906- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- Oral health in cancer treatment
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Healthcare during COVID-19 Pandemic
- Colorectal Cancer Treatments and Studies
- Antifungal resistance and susceptibility
- Hematological disorders and diagnostics
- Multiple Myeloma Research and Treatments
- Fungal Infections and Studies
- Childhood Cancer Survivors' Quality of Life
- Women's cancer prevention and management
- CAR-T cell therapy research
- Chronic Myeloid Leukemia Treatments
- Cytomegalovirus and herpesvirus research
- Viral-associated cancers and disorders
- COVID-19 and healthcare impacts
- Neutropenia and Cancer Infections
- Genomics and Rare Diseases
- Ear and Head Tumors
- Laser Applications in Dentistry and Medicine
- Mechanical Circulatory Support Devices
Hospital Sírio-Libanês
2012-2024
Hospital São Paulo
2005-2020
Palmetto Hematology Oncology
2019
Universidade Estadual de Campinas (UNICAMP)
2016
Hospital Israelita Albert Einstein
2005-2006
1. Introdução Atualmente, doenças cardiovasculares (DCV) e câncer são as principais causas de mortalidade em todo o mundo no Brasil.– As transições demográfica epidemiológica ocorridas recentemente nosso país resultaram aumento da expectativa vida população, hoje torno 76 anos, na modificação perfil saúde, que crônicas suas complicações prevalentes. Esses fatores ocasionam importantes desafios a necessidade uma agenda para políticas saúde possam [...]
Abstract The present study aimed to assess the sensitivity of Eastern Cooperative Oncology Group Performance Status (ECOG-PS) scale for scores other than 0 as a screening tool sarcopenia in onco-hematology patients. A retrospective cohort 104 patients aged > 19 years and treated at Diagnostic Imaging Center an outpatient clinic private tertiary hospital was conducted. Sarcopenia defined skeletal muscle index (SMI) ≤ 38.5 cm2/m2 women 52.4 men based on positron emission tomography-computed...
Drug-induced immune pancytopenia is considered an uncommon disorder.A 76-year-old woman with metastatic gastric adenocarcinoma received 15 cycles of FOLFOX-6 (oxaliplatin/folinic acid/fluorouracil) a complete response. Upon disease progression, she was restarted on FOLFOX; during the seventh cycle treatment, 1 hour after completing her oxaliplatin infusion, presented oral bleeding, petechiae and generalized hematomas. Her platelet (PLT) count decreased from 164 x 10(9)/L to less than 5...
Total body irradiation (TBI) at myeloablative doses is superior to chemotherapy-based regimens in young patients with acute lymphoblastic leukemia (ALL) undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, elderly and unfit patients, where reduced-intensity conditioning (RIC) are preferred, whether a TBI- or approach better, unexplored. Thiotepa can be used as part of ALL regimens. The aim the current study compare transplant outcomes after RIC thiotepa-based...
Mucormycosis is an invasive fungal disease caused by fungi from the Mucorales order that are found in soil and decaying organic debris. has been reported to be third most common stem cell transplanted patients. The have a tendency for vascular invasion, resulting thrombi development, which decreases blood supply leads extensive tissue necrosis. Here, authors present patient of mucormycosis affecting soft palate, oropharynx, hypopharynx type II diabetic male who underwent allogeneic...
The development of the Brazilian Registry Hematopoietic Cell Transplantation in collaboration with Center for International Blood and Marrow Transplant Research (CIBMTR) allowed an assessment activity general outcomes transplants Brazil. Here, we report updated activity. transplant centers their data to CIBMTR, using FormsNet3 platform. Information returns Cellular Therapy Bone Society (SBTMO) through Data Back Centers (DBtC) tool. from patients who received HCT 2012 2023 were extracted...
Chimeric antigen receptor T-cells (CAR T cells) are genetically modified cellular immunotherapies approved for standard of care treatment patients with lymphoma and leukemia worldwide. Here we report the initial activity in Brazilian centers through collaboration between Cellular Therapy Bone Marrow Transplant Society (SBTMO) Center International Blood Research (CIBMTR). A total 38 who received CAR cells 2020 2023. The median age was 47 years (range 4-77). Indications include Non-Hodgkin...
The first hematopoietic stem cell transplantation (HSCT) program in Latin America started 1979 at the federal university hospital Curitiba, Paraná, Brazil. Over years, number of centers performing transplants our country has increased tremendously, generating need to know results this treatment modality. Understanding HSCT scenario Brazil is still challenging, since not all Brazilian report data Center for International Blood and Marrow Research (CIBMTR). Despite improvement reporting over...
Availability of haploidentical donors has broadened utilization allogeneic hematopoietic cell transplantation (allo-HCT). Peripheral blood stem cells (PBSC) are being used with increased frequency in allo-HCT. We evaluated extent HLA disparity (2-3/8 versus 4/8 antigen mismatches) on post-allograft outcomes when using T-cell replete PBSC from for acute myeloid leukemia first complete remission. Primary objectives entailed assessing cumulative incidence grade 2-4 graft-versus-host disease...
Reduced-intensity-conditioned allogeneic stem cell transplantation (SCT) remains a potentially curative approach for patients with relapsed/refractory Hodgkin lymphoma (HL) after an autologous transplantation. In the absence of HLA-identical donor, haploidentical SCT (haplo-SCT) post-transplantation cyclophosphamide (PT-Cy) has been evaluated favorable preliminary results. We 24 who underwent haplo-SCT HL. The conditioning regimen consisted cyclophosphamide, fludarabine, and total body...
To investigate, in a large prospective multicenter study, whether 2-[18F]-fluoro-2-deoxy-d-glucose-positron emission tomography is sufficiently accurate to identify clinically important bone marrow involvement by Hodgkin's lymphoma replace routine biopsy developing tropical country.Patients newly diagnosed with were recruited from six cancer centers Brazil. All staged the results of positron tomography/computed that centrally reviewed and iliac crest biopsy. Patients classified as having...
The first HSCT program in Latin America started 1979 at the Federal University Hospital (Curitiba, Paraná). Over years, number of centers performing transplants country increased, generating need to know results this modality treatment. Understanding scenario Brazil is still challenging since not all Brazilian report data Center for International Blood and Marrow Research (CIBMTR). Although it has been improving over last infrastructure trained managers are lacking. partnership between...
Since the first hematopoietic stem cell transplantation (HSCT) was performed at Federal University Hospital (Curitiba, PR) in 1979, number of centers offering this modality treatment has increased. However, accessing comprehensive HSCT outcomes become a challenge due to lack an official Brazilian registry. The partnership between Cellular Therapy and Bone Marrow Transplant Society (SBTMO) Center for International Blood Research (CIBMTR) important milestone establishment registry (HSCTBR). By...
Abstract Collecting high quality data on race and ethnicity is crucial for clinical research, notably in genetic association studies, to avoid confounding by different ethnic background among patients, a bias referred as population stratification. In Brazil, describe we commonly use the National Institute of Geography Statistics (IBGE) classification, so-called “self-declared color”, but it acknowledged that defining ancestry phenotypic characteristics, especially countries with highly mixed...
Understanding the HSCT scenario in Brazil is challenging due to lack of a national registry that allows analysis results. The partnership between Brazilian Cellular Therapy and Bone Marrow Transplant Society (SBTMO) Center for International Blood Research (CIBMTR) allowed return data registered CIBMTR, through Data Back (DBtC), standardized organized way. With this database it was possible know demographic outcomes transplants performed Brazil. spreadsheet imported into Power BI desktop,...
High bone turnover disorders are characterized by excessive osteoclastic activity resulting in loss of mass and quality, fractures, deformities, debilitating pain, mobility hypercalcemia. These complications have a major impact quality life, control osteoclast is critical to reduce or prevent these skeletal events. Over the last 2 decades bisphosphonates became an integral part management disorders. Bisphosphonates, analogues pyrophosphate, bind hydroxyapatite crystals very high affinity for...
Introduction Venetoclax combined with hypomethylating agents (HMA) or low-dose cytarabine (LDC) has emerged as a promising therapy for acute myeloid leukemia (AML). However, there are scarce data on the use of this drug in context allogeneic hematopoietic cell transplantation (allo-HCT). We thus report case series patients using venetoclax-based AML prior to after allo-HCT. Methods Adult active receiving venetoclax + HMA/LDC before allo-HCT bridge following HCT salvage were included report....
This is an observational and cross-sectional study, carried out in May 2020, targeting adult individuals of both sexes who are members multiprofessional teams working Brazilian HSCT units the current period pandemic by completing analyzing a questionnaire. pre-formulated. that cannot access questionnaire were excluded from study. The analysis operation profile Brazil, through application pre-structured questionnaire, not accurate tool, since it assumes some premises may prove to be wrong,...