A5039016396- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Obstructive Sleep Apnea Research
- Sleep and Wakefulness Research
- Dementia and Cognitive Impairment Research
- Acute Myeloid Leukemia Research
- Neuroscience of respiration and sleep
- Lymphoma Diagnosis and Treatment
- Health, Nursing, Elderly Care
- Multiple Myeloma Research and Treatments
- Pharmacology and Obesity Treatment
- Public Health in Brazil
- Sleep and related disorders
- Aging, Elder Care, and Social Issues
- Chronic Myeloid Leukemia Treatments
- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Nutritional Studies and Diet
- Health disparities and outcomes
- SARS-CoV-2 and COVID-19 Research
- Mosquito-borne diseases and control
- Diabetes Management and Research
- Probiotics and Fermented Foods
- Dermatological and COVID-19 studies
- Research on Leishmaniasis Studies
Universidade de São Paulo
2019-2025
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2019-2024
Universidade Federal de São Paulo
2013-2019
Instituto do Sono
2015
Background: Most people with dementia live in low- and middle-income countries little is known about the potential for reducing these numbers by key risk factors. Objective: To investigate incidence reduction Brazil, Mozambique, Portugal (a culturally related, high-income country). Methods: We replicated previously published methods based on relative risks from previous studies, we estimated population-attributable (PAR) of seven modifiable factors associated (low educational attainment,...
ABSTRACT Immunocompromised individuals were considered high-risk for severe disease due to SARS COV-2 infection. This study aimed describe the safety of two doses COVID-19 adsorbed inactivated vaccine (CoronaVac; Sinovac/Butantan), followed by additional mRNA BNT162b2 (Pfizer/BioNTech) in immunocompromised (IC) adults, compared immunocompetent/healthy (H) individuals. phase 4, multicenter, open label included solid organ transplant and hematopoietic stem cell recipients, cancer patients...
This study aimed to evaluate the effects of zolpidem CR (controlled release) on sleep and nocturnal ventilation in patients with congestive heart failure, a population at risk for insomnia poor quality.Fifteen failure (ischemic cardiomyopathy) ejection fraction ≤ 45% NYHA functional class I or II were evaluated full polysomnography placebo-controlled, double-blind, randomized trial. Patients underwent three tests: (1) baseline and, after randomization, (2) new test 12.5 mg placebo, 1 week,...
Palliative care providers must seek to improve quality of life despite their patients' life-threating diseases, based on the concept total pain, which includes physical, psychological and spiritual pain. Understanding relationship between coping symptoms (especially depressive symptoms) could help healthcare teams better address needs. Across-sectional survey with aconvenient sample ambulatory palliative patients investigated pain through Hospital Anxiety Depressive (HAD) scale use...
Objective: To evaluate the safety and efficacy of a 5 mg sublingual dose zolpidem, compared to 10 oral dose, at bedtime "as needed" following middle-of-the-night awakenings. Methods: Participants were randomized into an group (oral zolpidem placebo "as-needed") "as-needed"). underwent medical evaluation, polysomnography, psychomotor vigilance test, completed questionnaires. Results: Of 85 patients, 67 met criteria for insomnia (48±10 years; 79% women) randomized. these, 46 92±5 days...
The first hematopoietic stem cell transplantation (HSCT) program in Latin America started 1979 at the federal university hospital Curitiba, Paraná, Brazil. Over years, number of centers performing transplants our country has increased tremendously, generating need to know results this treatment modality. Understanding HSCT scenario Brazil is still challenging, since not all Brazilian report data Center for International Blood and Marrow Research (CIBMTR). Despite improvement reporting over...
Gut colonization by multidrug resistant organisms(MDROs) is a risk factor for bloodstream infections(BSI) in the early phase of Hematopoietic Stem Cell Transplantation(HSCT). We evaluated, an exploratory study, impact Lactobacillus plantarum on modulation gut microbiome HSCT patients colonized MDROs. Participants were allocated to intervention group(IG=22) who received capsules L. plantarum(5x109 CFU) twice day until onset neutropenia and control group(CG=20). The V4 region 16S bacterial...
Abstract Background: Oral squamous cell carcinoma (OSCC) is a highly aggressive malignancy often arising from oral potentially malignant lesions (OPMD). Nicotine triggers pathways associated with tumor progression, angiogenesis, and metastasis, notably PI3K/AKT HIF-1. This study investigated the impact of nicotine on viability, migration, gene expression ( PIK3CA, AKT1, HIF-1α, GLUT1, CA9 VEGF ) in DOK SCC9 lines. Methods Results: lines, were cultured standard media conditions, exposed to...
Since the first hematopoietic stem cell transplantation (HSCT) was performed at Federal University Hospital (Curitiba, PR) in 1979, number of centers offering this modality treatment has increased. However, accessing comprehensive HSCT outcomes become a challenge due to lack an official Brazilian registry. The partnership between Cellular Therapy and Bone Marrow Transplant Society (SBTMO) Center for International Blood Research (CIBMTR) important milestone establishment registry (HSCTBR). By...
can inhibit the growth of multidrug-resistant organisms (MDROs) and modulate gut microbiome. However, data on hematopoietic stem cell transplantation (HSCT) are scarce.
Abstract Collecting high quality data on race and ethnicity is crucial for clinical research, notably in genetic association studies, to avoid confounding by different ethnic background among patients, a bias referred as population stratification. In Brazil, describe we commonly use the National Institute of Geography Statistics (IBGE) classification, so-called “self-declared color”, but it acknowledged that defining ancestry phenotypic characteristics, especially countries with highly mixed...
Hematopoietic Stem Cell Transplantation (HSCT) has relevant clinical problems that occur after years and require long-term patient follow-up. Several factors contribute to outcomes limit the design of trials, making observational studies an important tool for resolving questions. Data management (DM) is essential part developing good centers are stimulated organize report its data improve knowledge worldwide. Aim: Describe use Research Electronic Capture (REDCap) in DM a Clinical Therapy...