A5101893949- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Click Chemistry and Applications
- Peptidase Inhibition and Analysis
- Pesticide Exposure and Toxicity
- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Synthesis and Characterization of Heterocyclic Compounds
- Environmental Toxicology and Ecotoxicology
- Insect and Pesticide Research
- Mast cells and histamine
- Quinazolinone synthesis and applications
- Hippo pathway signaling and YAP/TAZ
- Cancer-related gene regulation
- Synthesis of Organic Compounds
- Cancer therapeutics and mechanisms
- 14-3-3 protein interactions
- Fungal Plant Pathogen Control
- HER2/EGFR in Cancer Research
- Cell death mechanisms and regulation
- Catalytic C–H Functionalization Methods
- Cancer Mechanisms and Therapy
- Synthesis of β-Lactam Compounds
- Epigenetics and DNA Methylation
Zhengzhou University
2016-2025
Chinese Center For Disease Control and Prevention
2025
Wuhan University
2024
Renmin Hospital of Wuhan University
2024
Shandong Center for Disease Control and Prevention
2022
China National Center for Food Safety Risk Assessment
2022
Shanghai Tenth People's Hospital
2018-2019
Tongji University
2018-2019
Walter Reed Army Institute of Research
2010-2012
Université de Montréal
1995
A series of novel chalcone-1,2,3-triazole-azole hybrids were designed, synthesized and evaluated for their antiproliferative activity against three selected cancer cell lines (SK-N-SH, EC-109 MGC-803). Most the compounds exhibited moderate to good all selected. Particularly, compound I-21 showed most excellent with an IC50 value 1.52 μM SK-N-SH cells. Further mechanism studies revealed that induced morphological changes cells possibly by inducing apoptosis. Novel derivatives in this work...
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and lethal malignancy characterized by dysregulated energy stromal metabolism. It strongly supported activated pancreatic stellate cells (PSC) which drive excessive desmoplasia tumor growth via metabolic crosstalk. Herein, programmed nanosystem designed to dual rectify the metabolism abnormalities of PDAC cells, overexpress glucose transporter 1(GLUT1) CD71, PSC for oncotherapy. The based on microenvironment-responsive liposome...
<bold>12k</bold> exhibited an IC<sub>50</sub> value of 1.53 μM against SK-N-SH cells by inducing apoptosis and arresting the cell cycle at G1 phase.
The chalcone and quinoline scaffolds are frequently utilized to design novel anticancer agents. As the continuation of our work on effective agents, we assumed that linking fragment scaffold through principle molecular hybridization strategy could produce compounds with potential activity. Therefore, quinoline-chalcone derivatives were designed synthesized, explored their antiproliferative activity against MGC-803, HCT-116, MCF-7 cells. Among these compounds, compound 12e exhibited a most...