A5079043235- Neonatal Respiratory Health Research
- Renal Diseases and Glomerulopathies
- Birth, Development, and Health
- Sperm and Testicular Function
- Prostate Cancer Treatment and Research
- Male Reproductive Health Studies
- Atherosclerosis and Cardiovascular Diseases
- Neonatal Health and Biochemistry
- Prostate Cancer Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Neurogenetic and Muscular Disorders Research
- Muscle Physiology and Disorders
- Neural dynamics and brain function
- Vasculitis and related conditions
- Urinary Tract Infections Management
- Pregnancy and preeclampsia studies
- Ion Transport and Channel Regulation
- Chronic Kidney Disease and Diabetes
- Vitamin D Research Studies
- Thyroid Cancer Diagnosis and Treatment
- Renal function and acid-base balance
- Thyroid Disorders and Treatments
- Neurobiology and Insect Physiology Research
- Electrolyte and hormonal disorders
- Photoreceptor and optogenetics research
Alexandria University
2003-2025
Chelsea and Westminster Hospital
2018-2022
University of Sadat City
2022
Hôpital Sahloul
2019-2021
University of Ottawa
2005-2020
Imperial College London
2018
Fayoum University
2017
Université Laval
2008-2011
York University
2010-2011
Ottawa Heart Institute
2009
The epididymal epithelium secretes membranous vesicles, called epididymosomes, with which a complex mixture of proteins is associated. These vesicles transfer to spermatozoa selected involved in sperm maturation. Epididymosomes the human excurrent duct have been described, but their protein composition and possible functions are unknown. were collected during vasovasostomy procedures, purified submitted liquid chromatography hybrid quadrupole time-of-flight mass spectrometry. From all...
The aim of this study was to investigate the role lymph node yield (LNY), ratio (LNR), and neutrophil lymphocyte (NLR) as prognostic factors, their impact on survival in patients with advanced laryngeal squamous cell carcinoma (LSCC).
To test the hypothesis that growth retardation in nonanion gap acidosis may be associated with impairment of hormone (GH) secretory patterns, we examined GH secretion rats made acidotic ammonium chloride ingestion. Considerable was demonstrated pair-fed and after 1 wk ingestion compared control. With stable metabolic sustained on 8th day experiment, pulsatile evaluated by blood samples drawn every 10 min for 6 h. Using deconvolution analysis to quantitate vivo rates, found significant...
To transfuse or not to premature infants" is still one of debatable issues in neonatal care that has been completely solved. Recognizing hemodynamically significant (HS) anemia might be part the solution. Our purposes were investigate hemodynamic effects late onset and red blood cells (RBCs) transfusion on neonates with gestational age 28-32 weeks tailor needs based variables Hb/HCT level. In current study, 36 anemic preterm infants a postnatal 3-9 weeks, all having hematocrit (HCT) level...
Concurrent norfloxacin concentrations in serum, kidney, and prostatic tissue were determined 14 patients. Mean ratios of concentration over serum 6.6 +/- 2.8 for the kidney 1.7 0.2 prostate samples. The levels above MICs most urinary pathogens.
Abstract We have used the paradoxical antigonadal effects of LHRH agonists as a chemical castration in advanced prostatic cancer. report early results phase II study on clinical efficacy agonist D‐Ser (TBU) 6 , des‐Gly‐NH 2 10 administered to patients with stage D carcinoma. Following dose‐range finding studies using either intranasal (IN) (200 μg twice/day or 500 twice/day) subcutaneous (SC) administration (50 once/day, we developed sequential combination SC (500 three times/day for seven...
BackgroundMouse models of mild spinal muscular atrophy (SMA) have been extremely challenging to generate. This paucity model systems has limited our understanding pathophysiological events in milder forms the disease and effect SMN depletion during aging.MethodsA mouse SMA, termed Smn2B/−;SMN2+/−, was generated by crossing Smn−/−;SMN2 Smn2B/2B mice. new characterized using behavioral testing, histology, western blot, muscle-nerve electrophysiology as well ultrasonography study classical SMA...
Abstract Up-regulation of utrophin in muscles represents a promising therapeutic strategy for the treatment Duchenne Muscular Dystrophy. We previously demonstrated that eEF1A2 associates with 5’UTR A to promote IRES-dependent translation. Here, we examine whether directly regulates expression and identify via an ELISA-based high-throughput screen, FDA-approved drugs upregulate both A. Our results show transient overexpression mouse causes increase IRES-mediated translation Through assessment...
Although it has been suggested that the ATP-sensitive K(+) (K(ATP)) channel protects muscle against function impairment, most studies have so far given little evidence for significant perturbation in integrity and of skeletal fibers from inactive mice lack K(ATP) activity their cell membrane. The objective was, therefore, to test hypothesis channel-deficient become damaged when are subjected stress. Wild-type (Kir6.2(-/-) mice) were 4-5 wk treadmill running at either 20 m/min with 0 degrees...
Innate immunity and, notably, Toll-like receptors (TLR), have an important role in atherogenesis. We tested the hypothesis that selective loss of TLR-2 by cells bone marrow (BM) origin will protect low-density receptor-deficient (Ldlr (-/-)) mice from both early- and late-stage atherosclerosis. BM Tlr2(+/+) Tlr2(-/-) littermates were used to reconstitute lethally irradiated Ldlr(-/-) mice. Following a recovery period, placed either on diet containing 21% saturated fat - 0.15% cholesterol for...
Abstract Aim The earlier the onset of proteinuria, higher incidence genetic forms. Therefore, we aimed to analyse spectrum monogenic proteinuria in Egyptian children presenting at age <2 years. Methods results 27‐gene panel or whole‐exome sequencing were correlated with phenotype and treatment outcomes 54 patients from 45 families. Results Disease‐causing variants identified 29/45 (64.4%) Mutations often occurred three podocytopathy genes: NPHS1 , NPHS2 PLCE1 (19 families). Some showed...
In an attempt to elucidate the mechanism of growth retardation in nephrotic syndrome, specific serum and hepatic factors were measured Sprague-Dawley rats which syndrome was produced by administration puromycin (1.5 mg.100 g body wt-1.day-1) for 12 days. On 13th day, results these animals compared with those equal number pair-fed control animals: mean dietary intake group 71% that (P < 0.001). Serum insulin-like factor (IGF) binding protein-3 significantly reduced 0.005) rats, groups....
We present our experience with the use of semirigid ureteroscopy for treatment ureteric stones in children less than or equal to 6 years age.
Humans are extremely sensitive to radial deformations of static circular contours (F. Wilkinson, H. R. Wilson, & C. Habak, 1998). Here, we investigate detection and identification periodic motion trajectories defined by these frequency (RF) patterns over a range frequencies 2–5 cycles. We showed that the average thresholds for RF from 1 4 min arc performance improves as power-law function frequency. also detected speeds. spatiotemporal global processing is involved in trajectory detection,...