A5059151133- Tissue Engineering and Regenerative Medicine
- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Electrospun Nanofibers in Biomedical Applications
- Cannabis and Cannabinoid Research
- Viral Infections and Outbreaks Research
- Neurogenesis and neuroplasticity mechanisms
- Genetics and Neurodevelopmental Disorders
- Influenza Virus Research Studies
- RNA Research and Splicing
- Reconstructive Surgery and Microvascular Techniques
- Ion channel regulation and function
- Memory and Neural Mechanisms
- Animal Behavior and Reproduction
- RNA and protein synthesis mechanisms
- GABA and Rice Research
- Muscle Physiology and Disorders
- Hepatitis B Virus Studies
- Neuroscience of respiration and sleep
- Burn Injury Management and Outcomes
- Anatomy and Medical Technology
- RNA modifications and cancer
- Evolution and Paleontology Studies
- Mesenchymal stem cell research
- Neuroendocrine regulation and behavior
Emory University
2017-2022
Wake Forest University
2015-2019
Forest Institute
2017-2019
Abstract Objective The endocannabinoid system (ECS) is comprised of cannabinoid receptors 1 and 2 (CB1R CB2R), endogenous ligands, regulatory enzymes, serves to regulate several important physiological functions throughout the brain body. Recent evidence suggests that ECS may be a promising target for treatment epilepsy, including epilepsy subtypes arise from mutations in voltage‐gated sodium channel SCN1A . objective this study was explore effects modulating CB2R activity on seizure...
A number of mutations in genes that encode ubiquitously expressed RNA-binding proteins cause tissue specific disease. Many these diseases are neurological nature revealing critical roles for this class the brain. We recently identified a gene encodes polyadenosine protein, ZC3H14 (Zinc finger CysCysCysHis domain-containing protein 14), nonsyndromic, autosomal recessive form intellectual disability. This finding reveals molecular basis disease and provides evidence is essential proper brain...
Arboreal lifestyles represent common and major habitat shifts among snakes. Major are often facilitated by particular traits that confer advantages in the new environment. Although studies have examined habits characteristics of arboreal snakes at level individual species or small clades, a broad survey has never been performed across all We surveyed literature to identify known summarize their general characteristics. then tested for associations between diversification rates reconstructed...
Oxytocin (OT) has broad effects in the brain and plays an important role cognitive, social, neuroendocrine function. OT also been identified as potentially therapeutic neuropsychiatric disorders such autism depression, which are often comorbid with epilepsy, raising possibility that it might confer protection against behavioral seizure phenotypes epilepsy. Dravet syndrome (DS) is early-life encephalopathy associated prolonged recurrent febrile seizures (FSs), treatment-resistant afebrile...
Current treatment options for repairing volumetric muscle loss injury involve the use of existing host tissue like muscular flaps or grafts. However, may not be available and donor site morbidity, such as functional volume deficiency, is often present. In this study, we developed a biofunctionalized muscle-derived decellularized extracellular matrix scaffolding system to utilize endogenous stem/progenitor cells in situ regeneration. We optimized decellularization process enhance cellular...
Voltage-gated sodium channel genes are an important family of human epilepsy genes. De novo missense mutations in SCN8A (encoding Na v 1.6) associated with a spectrum clinical presentation, including multiple seizure types, movement disorders, intellectual disability, and behavioral abnormalities such as autism. Patients often treated antiepileptic drugs, the most common being blockers. Cannabidiol (CBD) has been included component treatment regimens for some patients; however, to date,...
ABSTRACT For treatments requiring split‐thickness skin grafts, it is preferable to mesh the grafts. This reduces amount of excised and covers more wound area. The technique, however, destroys surface continuity, which results in scarring. Strain‐based bioreactors, on other hand, have successfully expanded grafts vitro within a 7‐day period, increasing graft coverage. After expansion, were tested porcine full‐thickness excisional model. Expanded take rate was 100%. Volumetric, histologic,...
Numerous SCN8A mutations have been identified, of which, the majority are de novo missense variants. Most result in epileptic encephalopathy; however, some associated with less severe phenotypes. Mouse models generated by knock-in human exhibit seizures and a range behavioral abnormalities. To date, there only few Scn8a mouse in-frame deletions or insertions, notably, none these lines increased seizure susceptibility. In current study, we report generation characterization two (ΔIRL/+...
N-methyl-D-aspartate receptors are glutamate-gated, calcium-permeable ion channels involved in a host of normal brain functions, including neuronal development. Traditionally, the GluN2A subunit, encoded by GRIN2A gene, is thought to signal and circuit maturation, given its unique expression pattern where transcripts low embryonically then significantly increase during preadolescence mice. Advances whole exome sequencing have identified mutations gene be causal several neuropathological...
You have accessJournal of UrologyStem Cell Research: Stem Research I1 Apr 2018PD33-12 IN VIVO EVALUATION OF FUNCTIONALIZED MUSCLE SCAFFOLDS FOR RECONSTRUCTION Lindsey Shapiro, Young Min Ju, John Jackson, James Yoo, Anthony Atala, and Sang Jin Lee ShapiroLindsey Shapiro More articles by this author , JuYoung Ju JacksonJohn Jackson YooJames Yoo AtalaAnthony Atala LeeSang View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.1567AboutPDF ToolsAdd to favoritesDownload CitationsTrack...
Abstract During Ebola virus (EBOV) infection, secreted glycoprotein (sGP) and viral protein 40 (VP40) are found in large quantities the serum of infected animals. Studies suggest that sGP only provides passive immunity by serving as a decoy to anti-EBOV antibodies, no role for soluble VP40 has been determined. Using an vitro model incorporating treatment THP-1 macrophages with recombinant EBOV VP40, we examined impact proteins upon key macrophage functions. Treatment inhibited production...