A5107994804- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Nerve injury and regeneration
- Adipose Tissue and Metabolism
- RNA and protein synthesis mechanisms
- Lysosomal Storage Disorders Research
- Glaucoma and retinal disorders
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neural Engineering
- Dermatological and Skeletal Disorders
- RNA Research and Splicing
- RNA modifications and cancer
- Corneal surgery and disorders
- Connexins and lens biology
- RNA regulation and disease
Emory University
2017-2020
Foundation Fighting Blindness
2020
Atlanta VA Medical Center
2015-2018
United States Department of Veterans Affairs
2014
Aerobic exercise is a common intervention for rehabilitation of motor, and more recently, cognitive function (Intlekofer Cotman, 2013; Wood et al., 2012). While the underlying mechanisms are complex, BDNF may mediate much beneficial effects to these neurons (Ploughman 2007; Griffin 2011; Real 2013). We studied aerobic on retinal undergoing degeneration. exercised wild-type BALB/c mice treadmill (10 m/min 1 h) 5 d/week or placed control static treadmills. After 2 weeks exercise, were exposed...
Purpose: Our previous investigations showed that involuntary treadmill exercise is neuroprotective in a light-induced retinal degeneration mouse model, and it may act through activation of tropomyosin-related kinase B (TrkB) receptors. This study investigated whether voluntary running wheel can be an inheritable model the degenerative disease retinitis pigmentosa (RP), rd10 mice. Methods: Breeding pairs C57BL/6J mice were given free-spinning (active) or locked (inactive) wheels. Pups weaned...
Abstract Diabetic retinopathy is a leading cause of vision loss. Treatment options for early are sparse. Exercise protects dying photoreceptors in models retinal degeneration, thereby preserving vision. We tested the protective effects exercise on and cognitive deficits type 1 diabetes model determined whether TrkB pathway mediates this effect. Hyperglycaemia was induced Long Evans rats via streptozotocin injection ( STZ ; 100 mg/kg). Following confirmed hyperglycaemia, both control diabetic...
A number of mutations in genes that encode ubiquitously expressed RNA-binding proteins cause tissue specific disease. Many these diseases are neurological nature revealing critical roles for this class the brain. We recently identified a gene encodes polyadenosine protein, ZC3H14 (Zinc finger CysCysCysHis domain-containing protein 14), nonsyndromic, autosomal recessive form intellectual disability. This finding reveals molecular basis disease and provides evidence is essential proper brain...
Purpose: Adams–Oliver syndrome is a rare, inherited disorder of embryologic development that affects multiple systems. Ocular manifestations have been poorly characterized because the low prevalence and high mortality disease when it associated with internal organ and/or ophthalmic manifestations. We present case in 13-year-old patient whose multimodal retinal imaging findings helped direct management. Methods: Single report reviewing medical records imaging. Results: Visual acuity upon...