A5026107880- Particle Accelerators and Free-Electron Lasers
- Particle accelerators and beam dynamics
- Gyrotron and Vacuum Electronics Research
- Photocathodes and Microchannel Plates
- Particle Detector Development and Performance
- Radiation Detection and Scintillator Technologies
- Laser Design and Applications
- solar cell performance optimization
- Plasma Diagnostics and Applications
- Advanced X-ray Imaging Techniques
- Photonic and Optical Devices
- Terahertz technology and applications
- Pulsed Power Technology Applications
- Electrostatic Discharge in Electronics
- Parkinson's Disease Mechanisms and Treatments
- Radiation Therapy and Dosimetry
- Laser-Matter Interactions and Applications
- Speech Recognition and Synthesis
- Muon and positron interactions and applications
- Silicon Carbide Semiconductor Technologies
- Scientific Computing and Data Management
- Natural Language Processing Techniques
- Topic Modeling
- Distributed and Parallel Computing Systems
- Laser-Plasma Interactions and Diagnostics
Thomas Jefferson National Accelerator Facility
2012-2024
Johns Hopkins Medicine
2024
Johns Hopkins University
2024
Abstract Pathologic α-synuclein (α-syn) spreads from cell-to-cell, in part, through binding to the lymphocyte-activation gene 3 (Lag3). Here we report that amyloid β precursor-like protein 1 (Aplp1) interacts with Lag3 facilitates binding, internalization, transmission, and toxicity of pathologic α-syn. Deletion both Aplp1 eliminates loss dopaminergic neurons accompanying behavioral deficits induced by α-syn preformed fibrils (PFF). Anti-Lag3 prevents internalization PFF disrupting...
Attention-based arbitrary style transfer methods have gained significant attention recently due to their impressive ability synthesize details. However, the point-wise matching within mechanism may overly focus on local patterns such that neglect remarkable global features of images. Additionally, when processing large images, quadratic complexity will bring high computational load. To alleviate above problems, we propose Holistic Style Injector (HSI), a novel attention-style transformation...
This contribution describes the latest milestones of a multiyear program to build and operate compact $\ensuremath{-}300\text{ }\text{ }\mathrm{kV}$ dc high voltage photogun with inverted insulator geometry alkali-antimonide photocathodes. Photocathode thermal emittance measurements quantum efficiency charge lifetime at average current up 4.5 mA are presented, as well an innovative implementation ion generation tracking simulations explain benefits biased anode repel beam line ions from...
Operation of the JLab IR Upgrade FEL at CW powers in excess 10 kW requires sustained production high electron beam by driver ERL. This turn demands attention to numerous issues and effects, including: cathode lifetime; control beamline RF system vacuum during current operation; longitudinal space charge; transverse matching irregular/large volume phase distributions; halo management; management remnant dispersive effects; resistive wall, wake-field, heating chambers; break up instability;...
High-power, relativistic electron beams from energy-recovering linacs have great potential to realize new experimental paradigms for pioneering innovation in fundamental and applied research. A major design consideration this generation of capabilities is the understanding halo associated with these bright, intense beams. In Letter, we report on measurements performed using 100 MeV, 430 kW cw beam linac at Jefferson Laboratory's Free Electron Laser facility as it traversed a set small...
Abstract Advances in superconducting linac technology offer the possibility of an upgrade Jefferson Lab Free Electron Laser (JLab FEL) facility to oscillator-based VUV-FEL that would produce 6 × 1012 coherent 100 eV photons per pulse at multi-MHz repetition rates fundamental. In this paper we present novel designs are verified by model calculations which have themselves been validated comparison with experimental performance measurements using continuous-wave free electron lasers (FELs)...
${\mathrm{Cs}}_{x}{\mathrm{K}}_{y}\mathrm{Sb}$ photocathodes grown on GaAs and molybdenum substrates were evaluated using a $\ensuremath{-}300\text{ }\text{ }\mathrm{kV}$ dc high voltage photogun diagnostic beam line. Photocathodes substrates, with varying antimony layer thickness (estimated range from $<20\text{ }\mathrm{nm}$ to $>1\text{ }\mathrm{um}$), yielded similar thermal emittance per rms laser spot size values ($\ensuremath{\sim}0.4\text{ }\mathrm{mm}\text{...
In 2012 Jefferson Laboratory's energy recovery linac (ERL) driven Free Electron Laser successful completed a transmission test in which high current CW beam (4.3 mA at 100 MeV) was transported through 2 mm aperture for 7 hours with losses as low 3 ppm. The purpose of the run to mimic an internal gas target DarkLight* - experiment designed search dark matter particle. ERL not again until late 2015 brief re-commissioning preparation next phase DarkLight. intervening years, FEL rebranded Low...
A non-invasive, real time, method for measuring the longitudinal emittance of electron bunches can be realized by using electro-optic (EO) detection schemes. Implementation an EO beam diagnostic within Colorado State University and Jefferson Laboratory beamlines necessitates investigation into how high average power beams affect various crystals. Damage mechanisms from proximity to e-beam heavy radiation halo damage viability such a procedure. This study seeks characterize these effects...
A polarimeter was constructed to measure the longitudinal polarization of a spin-polarized electron beam at 5 and 7 MeV. The takes advantage Compton scattering between circularly polarized bremsstrahlung photons produced by longitudinally striking copper radiator electrons orbiting iron atoms an analyzing magnet. This so-called transmission is compact relatively inexpensive compared Mott-scattering polarimeters because no spin manipulator required. work presents design radiator, magnet,...
From the early days of free-electron lasers (FELs), idea lasing at wavelengths where gain media had not previously existed was one most attractive aspects these devices. The spectral region in soft X-ray both inviting, due to exciting physics could do with such a source, and challenging, need for very bright electron beam (high charge density), high overcome cavity losses, cost providing all this energies high-duty-cycle beams. Electron brightness is defined as ratio peak current product...