Manjari Sriparna
A5054841030- Parkinson's Disease Mechanisms and Treatments
- Ocular Infections and Treatments
- SARS-CoV-2 and COVID-19 Research
- Alzheimer's disease research and treatments
- SARS-CoV-2 detection and testing
- Neuroinflammation and Neurodegeneration Mechanisms
- Animal Virus Infections Studies
- Vitamin C and Antioxidants Research
- Ocular Surface and Contact Lens
- Intraocular Surgery and Lenses
- Nuclear Receptors and Signaling
- Therapeutic Uses of Natural Elements
- Pharmacological Effects and Toxicity Studies
- Advanced Nanomaterials in Catalysis
- Childhood Cancer Survivors' Quality of Life
- Graphene and Nanomaterials Applications
- Acute Myeloid Leukemia Research
- Legionella and Acanthamoeba research
- Electrochemical sensors and biosensors
Virginia Commonwealth University
2023-2024
Johns Hopkins Medicine
2021-2024
Johns Hopkins University
2021-2024
National Institute of Allergy and Infectious Diseases
2021
National Institutes of Health
2021
University of Richmond
2021
Virginia Commonwealth University Medical Center
2021
A look at variant-specific boosters The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants concern (VOCs) has raised the question whether current COVID-19 vaccines protect against VOCs and if a variant specific vaccine may be needed. Of currently identified VOCs, Delta is believed to most transmissible, whereas Beta appears resistant. Corbett et al . looked effect boosting using either original WA-1 strain or variant–specific booster. Around 6 months after...
Abstract Pathologic α-synuclein (α-syn) spreads from cell-to-cell, in part, through binding to the lymphocyte-activation gene 3 (Lag3). Here we report that amyloid β precursor-like protein 1 (Aplp1) interacts with Lag3 facilitates binding, internalization, transmission, and toxicity of pathologic α-syn. Deletion both Aplp1 eliminates loss dopaminergic neurons accompanying behavioral deficits induced by α-syn preformed fibrils (PFF). Anti-Lag3 prevents internalization PFF disrupting...
Aggregation of misfolded α-synuclein (α-syn) is the major component Lewy bodies and neurites in Parkinson's disease (PD) related α-synucleinopathies. Some α-syn mutations (e.g., A53T) familial PD recapitulate pathology transgenic mice, which supports importance pathologic driving pathogenesis Lymphocyte activation gene 3 (Lag3) a receptor fibrils facilitating spread; however, role Lag3 mediating mice not clear. Here, we report that depletion human A53T (hA53T) significantly reduces level...
Abstract Purpose To determine the prevalence and reasons for delays in diagnosis patients with Acanthamoeba keratitis (AK) presenting to Wilmer Eye Institute, Baltimore, Maryland. Methods This retrospective study analysed all culture‐positive AK seen between 2012 2019 at a tertiary referral centre. Patient demographic information, clinical history, risk factors, symptom duration, patterns, slit lamp examination findings, visual acuity need surgery were collected. Results The included 45 eyes...
Abstract Pathologic α-synuclein (α-syn) spreads from cell-to-cell, in part, through binding to the lymphocyte-activation gene 3 (Lag3). Here we report that amyloid β precursor-like protein 1 (Aplp1) forms a complex with Lag3 facilitates binding, internalization, transmission, and toxicity of pathologic α-syn. Deletion both Aplp1 eliminates loss dopaminergic neurons accompanying behavioral deficits induced by α-syn preformed fibrils (PFF). Anti-Lag3 prevents internalization PFF disrupting...
Neutralizing antibody responses gradually wane after vaccination with mRNA-1273 against several variants of concern (VOC), and additional boost vaccinations may be required to sustain immunity protection. Here, we evaluated the immune in nonhuman primates that received 100 µg vaccine at 0 4 weeks were boosted week 29 (homologous) or mRNA-1273.β (heterologous), which encompasses spike sequence B.1.351 (beta β) variant. Reciprocal ID 50 pseudovirus neutralizing geometric mean titers (GMT) live...
Intravenous vitamin C was administered following hematopoietic stem cell transplant to mitigate nonrelapse mortality (NRM) in a Phase II clinical trial.
To evaluate baseline characteristics, microbiological spectrum, management, and outcomes of patients with culture-proven fungal keratitis.Retrospective review all keratitis seen over 6 years at a tertiary referral center.The present study included 62 eyes from patients. Infection filamentous organisms was more common than yeast (66.1% vs 27.4%). The most were Fusarium (17.7%) Aspergillus (16.1%), while the Candida (24.2%). main predisposing factor for contact lens use. Yeast is associated an...
Intravenous (IV) vitamin C improves organ function and reduces inflammation in sepsis, an inflammatory state like the post-hematopoietic stem cell transplant (SCT) milieu. The safety efficacy of parenteral after allogeneic hematopoietic (HSCT) were evaluated a phase I/II trial clinical outcomes compared with propensity score - matched historical control.