A5072907592- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Influenza Virus Research Studies
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Neurological disorders and treatments
- PARP inhibition in cancer therapy
- Mitochondrial Function and Pathology
- Renal Diseases and Glomerulopathies
- Vaccine Coverage and Hesitancy
- Heat shock proteins research
- Nuclear Receptors and Signaling
- Animal Disease Management and Epidemiology
- Pituitary Gland Disorders and Treatments
- Electrolyte and hormonal disorders
- Chronic Myeloid Leukemia Treatments
- Abdominal vascular conditions and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Cytokine Signaling Pathways and Interactions
- Bacterial Infections and Vaccines
- Atomic and Molecular Physics
- X-ray Spectroscopy and Fluorescence Analysis
- Protein Structure and Dynamics
- Monoclonal and Polyclonal Antibodies Research
- Superconducting Materials and Applications
Peking Union Medical College Hospital
2024
Shanghai Institute of Organic Chemistry
2019-2024
Chinese Academy of Sciences
2005-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Institute of Modern Physics
2022-2024
Bio-Medical Science (South Korea)
2023
University of Chinese Academy of Sciences
2019-2021
Institute of Zoology
2005
The spread of pathological α-synuclein (α-syn) is a crucial event in the progression Parkinson's disease (PD). Cell surface receptors such as lymphocyte activation gene 3 (LAG3) and amyloid precursor-like protein 1 (APLP1) can preferentially bind α-syn over monomeric state to initiate cell-to-cell transmission. However, molecular mechanism underlying this selective binding unknown. Here, we perform an array biophysical experiments reveal that LAG3 D1 APLP1 E1 domains commonly use alkaline...
Abstract Pathologic α-synuclein (α-syn) spreads from cell-to-cell, in part, through binding to the lymphocyte-activation gene 3 (Lag3). Here we report that amyloid β precursor-like protein 1 (Aplp1) interacts with Lag3 facilitates binding, internalization, transmission, and toxicity of pathologic α-syn. Deletion both Aplp1 eliminates loss dopaminergic neurons accompanying behavioral deficits induced by α-syn preformed fibrils (PFF). Anti-Lag3 prevents internalization PFF disrupting...
Amyloid aggregation of pathological proteins is closely associated with a variety neurodegenerative diseases, and α-synuclein (α-syn) deposition Tau tangles are considered hallmarks Parkinson's disease Alzheimer's disease, respectively. Intriguingly, α-syn have been found to co-deposit in the brains individuals dementia parkinsonism, suggesting potential role cross-talk between these two pathologies. Here we show that monomeric variants Tau, Tau23 K19, synergistically promote amyloid...
The 2004 outbreaks of highly pathogenic avian influenza H5N1 disease in China led to a great poultry loss and society attention. A survey viruses was conducted on tree sparrows (Passer montanus) collected 2004. Four were isolated from free-living sparrows. results the whole-genome analysis indicated that an virus with new genotype is circulating among hemagglutinin neuraminidase genes derived Gs/Gd/96-like nuclear protein gene descended 2001 viruses, while other inner originated unknown...
α-Synuclein (α-Syn) forms pathological amyloid aggregates deposited in Lewy bodies and neurites the brain of Parkinson's disease (PD) patients. Heat shock proteins (Hsps) are major components cellular chaperone network, which responsible for preventing from aggregation. Different Hsps were reported to interact with α-syn. However, underlying mechanism interplay between α-syn different remains unclear. Here, by combing NMR spectroscopy, electron microscope other biochemical approaches, we...
The isomer depletion of ^{93m}Mo was recently reported [Chiara et al., Nature (London) 554, 216 (2018)NATUAS0028-083610.1038/nature25483] as the first direct observation nuclear excitation by electron capture (NEEC). However, measured probability 1.0(3)% is far beyond theoretical expectation. In order to understand inconsistency between theory and experiment, we produce nuclei using ^{12}C(^{86}Kr,5n) reaction at a beam energy 559 MeV transport residues detection station away from target...
Background: Influenza is a serious contagious disease caused by influenza virus. It particularly dangerous for children, potentially leading to severe and even fatal complications. The aim of this study was evaluate the safety immunogenicity two candidate quadrivalent subunit vaccines in children aged 6–35 months. Methods: subjects were randomly divided into three groups at 1:1:1 ratio received corresponding vaccines: QIV-Sub-HD (Quadrivalent Subunit Vaccine, High Dose), QIV-Sub-LD Low Dose)...
Neutrophil extracellular traps (NETs) contribute to inflammation and are implicated in autoimmune diseases; however, their role IgA nephropathy (IgAN) remains unclear. This study aimed investigate the involvement of NETosis IgAN its impact on renal injury mesangial cell function, utilizing patient samples, mouse models, vitro assays. RNA sequencing was performed peripheral blood mononuclear cells (PBMCs) from patients identify differentially expressed genes (DEGs) NETosis-related pathways....
Tau hyper-phosphorylation and deposition into neurofibrillary tangles have been found in brains of patients with Alzheimer’s disease (AD) other tauopathies. Molecular chaperones are involved regulating the pathological aggregation phosphorylated (pTau) modulating progression. Here, we report that nicotinamide mononucleotide adenylyltransferase (NMNAT), a well-known NAD+ synthase, serves as chaperone pTau to prevent its amyloid vitro well mitigate pathology fly tauopathy model. By combining...
Abstract Pathologic α-synuclein (α-syn) spreads from cell-to-cell, in part, through binding to the lymphocyte-activation gene 3 (Lag3). Here we report that amyloid β precursor-like protein 1 (Aplp1) forms a complex with Lag3 facilitates binding, internalization, transmission, and toxicity of pathologic α-syn. Deletion both Aplp1 eliminates loss dopaminergic neurons accompanying behavioral deficits induced by α-syn preformed fibrils (PFF). Anti-Lag3 prevents internalization PFF disrupting...
Quadrivalent influenza inactivated vaccine (IIV4) is more likely to provide wider protection against yearly circulating viruses than trivalent (IIV3). In this study, a total of 320 participants were allocated four age cohorts (6–35 months, 3–8 years, 9–17 and ≥ 18 years; 80 participants/cohort) according their actual date birth. Participants in each cohort randomly assigned two groups receive intramuscular injection the trial or comparative one-dose (3–8 years,and years) schedule on day 0...
Poly (ADP-ribose) polymerase inhibitors (PARPis) are emerging targeted therapeutic agents in oncology, primarily indicated for ovarian and metastatic breast cancer. Acute kidney injury (AKI) has been observed patients undergoing PARPi treatment, while there is still a lack of comprehensive comparisons AKI associated with different PARPis. Our study aimed to extensively characterize the renal adverse effects (RAEs) using real-world data.
High-spin states of $^{94}\mathrm{Nb}$ have been studied by in-beam $\ensuremath{\gamma}$-ray spectroscopic methods using the $^{82}\mathrm{Se}(^{18}\mathrm{O},p5n)^{94}\mathrm{Nb}$ reaction at beam energies 82 and 88 MeV. Particle-$\ensuremath{\gamma}\text{\ensuremath{-}}\ensuremath{\gamma}$ coincidence measurements CsI high-purity germanium arrays are employed to gain selectivity Nb isotopic products. The level scheme has extended up excitation energy...
Background: Despite some progress in pneumococcal immunization, the global burden of infection remains high, and disease a public health concern. Studies at home abroad have found that 23-valent polysaccharide vaccine (PPV23) vaccination can effectively prevent invasive disease. This phase Ⅰ clinical study assessed safety immunogenicity PPV23 candidate.Methods: All subjects were randomly assigned to receive one dose intramuscular injection experimental or control ratio 1:1. The incidence any...
Abstract Tau hyper-phosphorylation and deposition into neurofibrillary tangles have been found in brains of patients with Alzheimer’s disease (AD) other tauopathies. Molecular chaperones are involved regulating the pathological aggregation phosphorylated (pTau) modulating progression. Here, we report that nicotinamide mononucleotide adenylyltransferase (NMNAT), a well-known NAD synthase, serves as chaperone pTau to prevent its amyloid vitro well mitigate pathology fly tauopathy model. By...