A5057156544- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Genetic factors in colorectal cancer
- Ultrasound and Hyperthermia Applications
- Virus-based gene therapy research
- Cancer Immunotherapy and Biomarkers
- Nanoparticle-Based Drug Delivery
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Immune cells in cancer
- Polysaccharides and Plant Cell Walls
- Glycosylation and Glycoproteins Research
- Nanoplatforms for cancer theranostics
- Electromagnetic Fields and Biological Effects
- Microwave Imaging and Scattering Analysis
- Gut microbiota and health
- RNA Interference and Gene Delivery
- Cancer Cells and Metastasis
- Microscopic Colitis
- Colorectal and Anal Carcinomas
- Pancreatic and Hepatic Oncology Research
- Wireless Body Area Networks
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Electrical and Bioimpedance Tomography
Czech Academy of Sciences, Institute of Microbiology
2015-2025
Czech Academy of Sciences
2016-2025
Engineering Academy of the Czech Republic
2024
Institute of Microbiology
2018
Czech Academy of Sciences, Institute of Animal Physiology and Genetics
2014-2015
University of Louisville
2014
Czech Technical University in Prague
2009-2014
University of Pisa
1991-2006
Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro
2001-2002
General Department of Preventive Medicine
1989
A total of 250 patients with rectal adenocarcinoma were operated on at the University Chicago Medical Center between 1965 and 1981. The operation performed was curative resection in 154 patients, palliative 16 diverting colostomy 21 exploratory laparotomy 11 transanal removal 48 patients. Of resections, 115 abdomino-perineal (APR), three proctocolectomies, 36 low anterior resections (LAR). No anastomotic complications observed this latter group. Operative mortality 3%. Complete follow-up...
Intestinal microbiota are considered to play an important role both in colorectal tumor development and the modulation of mucosal immunity. Studies on animals reared germ-free (GF, without intestinal microbiota) versus conventional (CV, with regular colonization bowel) conditions can aid clarifying influence bacteria carcinogenesis anticancer immune response. The capability environment modulate immunity not only at but also systemic level is still open question. In our study we found that,...
Glyco-coat changes on cancer cells due to aberrant glycosylation are potential targets for immune recognition through lectin-like receptors cells. These include natural killer (NK), CD8+ and CD4+ lymphocytes, all reported have, together with cytokines, important functions in antitumor immunity. The aim of this study was evaluate a possible role synthetic monodisperse multivalent neo-glycoconjugates, namely glycodendrimers, as new approach anticancer modulation carbohydrate-mediated...
Nanoparticle-based systems are promising for the development of imaging and therapeutic agents. The main advantage nanoparticles over traditional lies in possibility loading multiple functionalities onto a single molecule, which useful and/or diagnostic purposes. These include targeting moieties able to recognize receptors overexpressed by specific cells tissues. However, targeted delivery requires an accurate system design. We present here rationally designed, genetically engineered,...
A hallmark of cancer, including pancreatic ductal adenocarcinoma (PDA), is a massive stromal and inflammatory reaction. Many efforts have been made to identify the anti- or protumoral role cytokines immune subpopulations within stroma. Here, we investigated interleukin-17A (IL17A) its effect on tumor fibroblasts microenvironment. We used spontaneous PDA mouse model (KPC) crossed IL17A knockout mice show an extensive desmoplastic reaction, without impaired infiltration. Macrophages,...
With increasing amounts of data showing significant immunostimulating effects glucan, it is not surprising that attention also focused on commercially farmed animals. Despite marked progress, development more efficient uses glucan in pig farming still needs substantial additional research.