A5026944924- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Disease Prevention
- Cardiovascular Syncope and Autonomic Disorders
- Retinal Imaging and Analysis
- Hormonal Regulation and Hypertension
- Cardiovascular Disease and Adiposity
- Sodium Intake and Health
- Retinal Diseases and Treatments
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Hemodynamic Monitoring and Therapy
- EEG and Brain-Computer Interfaces
- Retinal and Optic Conditions
- Muscle activation and electromyography studies
- Functional Brain Connectivity Studies
- Cardiac electrophysiology and arrhythmias
- Inflammatory Biomarkers in Disease Prognosis
- Lipoproteins and Cardiovascular Health
- Extracellular vesicles in disease
- Glaucoma and retinal disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Adipose Tissue and Metabolism
- Cardiac Arrhythmias and Treatments
- Obesity, Physical Activity, Diet
University Medical Center Freiburg
2024-2025
University of Freiburg
2024-2025
Royal Perth Hospital
2019-2024
The University of Western Australia
2019-2024
Hospital Research Foundation
2021-2023
RPH Research Foundation
2023
Commonwealth Scientific and Industrial Research Organisation
2021-2023
Lions Eye Institute
2023
Australian e-Health Research Centre
2021
University of Lübeck
2019-2021
Recent sham-controlled randomized clinical trials have confirmed the safety and efficacy of catheter-based renal denervation (RDN). Long-term data beyond 3 years are scarce. Here, we report on outcomes after RDN in a cohort patients with resistant hypertension an average ≈9-year follow-up (FU).We recruited who were previously enrolled various applying radiofrequency energy for blood pressure (BP) lowering. All participants had baseline assessments before repeat assessment at long-term FU...
Abstract Efforts to limit the impact of coronavirus disease (COVID‐19) pandemic led implementation public health measures and reallocation resources. To investigate trends in blood pressure (BP), hypertension BMI Australian population during COVID‐19 pandemic, data from publicly accessible stations were analyzed. Average BP measured by SiSU Health Station network Australia over 1.6 million screenings compared between years 2018 2021. Additionally, paired trajectories for development before...
BACKGROUND: Low-dose combinations are a promising intervention for improving blood pressure (BP) control but their effects on therapeutic inertia uncertain. METHODS: Analysis of 591 patients randomized to an ultra-low-dose quadruple pill or initial monotherapy. The episode was defined as patient visit with BP >140/90 mm Hg without intensification antihypertensive treatment. We compared the frequency episodes between Quadpill and monotherapy proportion total population (intention-to-treat...
Microvascular disease and rarefaction are key pathological hallmarks of hypertension. The retina uniquely allows direct, non-invasive investigation the microvasculature. Recently developed optical coherence tomography angiography now fine retinal capillaries, which may provide a superior marker overall vascular damage. This was prospective cross-sectional study to collect capillary density data on 300 normal eyes from 150 hypertensive adults, investigate possible associations with other...
Summary Myocardial injury due to ischaemia within 30 days of non‐cardiac surgery is prognostically relevant. We aimed determine the discrimination, calibration, accuracy, sensitivity and specificity single‐layer multiple‐layer neural networks for myocardial death postoperative days. analysed data from 24,589 participants in Vascular Events Non‐cardiac Surgery Patients Cohort Evaluation study. Validation was performed on a randomly selected subset study population. Discrimination by vs....
Introduction: Maintaining renin-angiotensin-aldosterone system inhibition (RAASi) in advanced chronic kidney disease (CKD) to delay CKD progression is still controversial. This due potential side effects associated with RAASi, such as a decline glomerular filtration rate (GFR) and hyperkalemia. study aims examine the effect of RAASi on failure (eGFR <15 ml/min/1.73 m2, stage 5) real-life outpatient cohort. Methods: single-center retrospective observational presents data from 954...
ABSTRACT Background This aimed to quantify the association between dual trajectory patterns combining seven central adiposity (CA) indices and fasting plasma glucose (FPG) with cardiovascular disease (CVD) risk in adults, compare their predictive performance. Methods The Kailuan Study, a prospective study initiated June 2006, included 39 772 adults without pre‐existing CVD as of 2010. Dual trajectories CA combined FPG were recorded from 2006 2010 predict 2021. Cox regression models used...
To study the interplay of metabolic state (hungry vs. satiated) and glucose administration (including hormonal modulation) on brain function, resting-state functional magnetic resonance imaging (rs-fMRI) blood samples were obtained in 24 healthy normal-weight men a repeated measurement design. Participants measured twice: once after 36 h fast (except water) under satiation (three meals/day for h). During each session, rs-fMRI hormone concentrations recorded before 75 g oral dose glucose. We...
Influential guidelines currently define hypertension at different thresholds of blood pressure (BP). The global May Measurement Month initiative provides a unique opportunity to estimate the potential consequences universal lowering BP on prevalence based large, real-world, patient-level data set.The average second and third 3 attended readings after 5 minutes rest from 4 021 690 standardized, opportunistic screenings in various settings 2017 2019 initiatives 104 countries were analyzed...
Arterial stiffness is an important predictor of cardiovascular events, independent traditional risk factors. Stiffening arteries, though adaptive process to hemodynamic load, results in substantial increase the pulsatile forces that detrimentally affects microcirculation perfusing vital organs such as brain, heart and kidneys. Studies have proposed arterial precedes may contribute development hypertension individuals with obesity. Our study sought determine gender-based effects on stiffening...
Objective: Although the detrimental effect of increased mean blood pressure (BP) is well established, role dynamic and circadian features BP less defined but may be similarly important. In this prospective analysis hypertensive patients from a tertiary hospital hypertension clinic, we investigated whether presence night-time systolic associated with more pronounced end-organ damage as assessed by measures pulse wave (PWA) velocity (PWV). Methods: A cohort 222 consecutive underwent ambulatory...
The hypothalamus and insular cortex play an essential role in the integration of endocrine homeostatic signals their impact on food intake. Resting-state functional connectivity alterations hypothalamus, posterior insula (PINS) anterior (AINS) are modulated by metabolic states caloric Nevertheless, a deeper understanding how these factors affect strength between PINS AINS is missing. This study investigated whether effective (directed) within this network varies as function prandial (hunger...
Elevated office blood pressure (BP) has previously been associated with increased levels of circulating extracellular vesicles (EVs). The present study aimed to assess the relationship between platelet derived EVs, ambulatory BP parameters, and pulse wave velocity as a marker macrovascular organ damage. A total 96 participants were included in study. Platelet-derived (pEVs) evaluated by flow cytometry (CD41+/Annexin v+). evaluation unobserved automated monitoring. Carotid-femoral (PWV) was...