A5100333645- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Acute Kidney Injury Research
- Long-Term Effects of COVID-19
- Cancer Mechanisms and Therapy
- Tea Polyphenols and Effects
- Parasitic infections in humans and animals
- Liver Disease Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- Microbial Metabolites in Food Biotechnology
- Ophthalmology and Eye Disorders
- Fermentation and Sensory Analysis
- Diabetes and associated disorders
- Food Quality and Safety Studies
- Food composition and properties
- Medical Imaging and Analysis
- Organ Transplantation Techniques and Outcomes
- Artificial Intelligence in Healthcare
- Parasitic Infections and Diagnostics
- Respiratory viral infections research
- Liver Disease and Transplantation
- Pregnancy and preeclampsia studies
- Phytochemicals and Antioxidant Activities
- COVID-19 and healthcare impacts
- Renal Transplantation Outcomes and Treatments
Capital Medical University
2021-2025
Pennsylvania State University
2007-2025
Yunnan University
2025
Beijing Obstetrics and Gynecology Hospital
2024-2025
Peking University
2023-2025
Thompson Rivers University
2025
Shanxi Medical University
2024
Qujiang People's Hospital
2024
Xuzhou Medical College
2024
Ministry of Agriculture and Rural Affairs
2024
Abstract Mechanical loads are required for optimal bone mass. One mechanism whereby mechanical transduced into localized cellular signals is strain‐induced fluid flow through lacunae and canaliculi of bone. Gap junctions (GJs) between osteocytes osteoblasts provides a flow‐induced detected by to osteoblasts. We have demonstrated the importance GJ gap junctional intercellular communication (GJIC) in intracellular calcium prostaglandin E 2 (PGE ) increases response flow. Unapposed connexons,...
Mitochondrial dysfunction has important roles in the pathogenesis of AKI, yet therapeutic approaches to improve mitochondrial function remain limited. In this study, we investigated pathogenic role microRNA-709 (miR-709) mediating impairment and tubular cell death AKI. a cisplatin-induced AKI mouse model biopsy samples human kidney tissue, miR-709 was significantly upregulated proximal cells (PTCs). The expression renal PTCs patients with correlated severity injury. cultured PTCs,...
Increasing evidence suggests that dysregulated immune responses are associated with the clinical outcome of coronavirus disease 2019 (COVID-19). Nucleocapsid protein (NP)-, spike (S)-, receptor binding domain (RBD)- specific immunoglobulin (Ig) isotypes, IgG subclasses and neutralizing antibody (NAb) were analyzed in 123 serum from 63 hospitalized patients severe, moderate, mild or asymptomatic COVID-19. Mild to modest correlations found between severity antigen serum, which IgG1 IgG3...
Objectives Mental health disorders (MHD) rank third for US adult hospitalisations. Given the substantial prevalence of ‘Long COVID’ in SARS-CoV-2 survivors, this study aims to assess its association with increased MHD risk using extensive real-world data. Design A retrospective cohort propensity score matching was conducted. We used International Classification Diseases, 10th Revision codes identify individuals Long COVID status and COVID-19 histories. Multivariable stratified Cox...
: Cisplatin nephrotoxicity is an important cause of acute kidney injury (AKI), limiting cisplatin application in cancer therapy. Growing evidence has suggested that genome instability, telomeric dysfunction, and DNA damage were involved the tubular epithelial cells (TECs) cisplatin-induced AKI (cAKI). However, exact mechanism largely unknown.
Lack of access to safe, affordable, timely and adequate pregnancy termination care, the stigma associated with abortion in low-middle income countries (LMICs), pose a serious risk women's physical mental well-being throughout lifespan. Factors their heterogeneity across LMICs previously have not been thoroughly investigated. We aim determine relative significance factors its variation countries. Analysis cross-sectional nationally representative household surveys carried out 36 from 2010...
Catechins are crucial in determining the flavour and health benefits of tea, but it remains unclear that how light intensity regulates catechins biosynthesis. Therefore, we cultivated tea plants a phytotron to elucidate response mechanism biosynthesis changes.In 250 μmol·m- 2·s- 1 treatment, contents epigallocatechin, epigallocatechin gallate total were increased by 98.94, 14.5 13.0% respectively, compared with those 550 treatment. Meanwhile, photosynthetic capacity was enhanced including...
Abstract Purpose The aim of this study was to investigate the clinical efficacy full endoscopic lumbar annulus fibrosus suture in treatment single-segment disc herniation (LDH). Methods data patients with LDH who underwent discectomy from January 2017 2019 our hospital were retrospectively analysed. Patients combined divided into group A, and those simple B. general information, surgery-related data, visual analog scale (VAS), Oswestry disability index (ODI), modified MacNab score at last...
Background: The pathophysiology of posterior tibial tendon dysfunction (PTTD) is poorly understood. It has been theorized that changes in hormone physiology may be a factor influencing health. Estrogen's influence on the fibroblast studied other musculoskeletal tissues. Gender differences anterior cruciate ligament (ACL) injuries have and it discovered Estrogen receptor (ER) as well Progesterone (PR) are expressed ACL. Material Methods: Eight patients with PTTD requiring surgery were...
Abstract Adult stem cells, including mesenchymal display plasticity in that they can differentiate toward various lineages bone cartilage fat and other types of connective tissue cells. However, it is not clear what factors direct adult cell lineage commitment terminal differentiation. Emerging evidence suggests extracellular physical cues have the potential to control specification. In this perspective article, we review recent findings on biomaterial surface mechanical signal regulation...
Abstract Background Thrombosis and coagulopathy are highly prevalent in critically ill patients with COVID-19 increase the risk of death. Immunothrombosis has recently been demonstrated to contribute thrombotic events coagulopathy. As primary components immunothrombosis, neutrophil extracellular traps (NETs) could be induced by complement cascade other proinflammatory mediators. We aimed explore clinical roles NETs regulation on NET formation COVID-19. Methods recruited 135 measured plasma...
Forkhead box O3 (FOXO3) is a critical transcription factor within the FOXO family that regulates various physiological and pathological processes, including metabolism, stress response, apoptosis, cell cycle control. FOXO3 activity primarily regulated by post-translational modifications, phosphorylation, acetylation, ubiquitination, while interacting with key pathways such as PI3K/Akt AMPK. These regulate FOXO3's localization cells, influencing processes like autophagy, oxidative resistance,...
To understand the molecular properties of matrilin-3, a newly discovered member novel extracellular matrix protein family, we cloned MAT-3 cDNA from developing chicken sterna. Real time quantitative reverse-transcription polymerase chain reaction indicates that mRNA is mainly expressed in proliferation zone growth plate. It also maturation zone, overlapping with mature chondrocyte-abundant matrilin-1 mRNA. This suggests matrilin-3 may self-assemble addition to its co-assembly during...
Context: Previous studies have reported that pregnant women with non-alcoholic fatty liver disease (NAFLD) face an increased risk of gestational hypertension (GH) and preeclampsia (PE). However, no study has assessed the relationship between Hepatic Steatosis Index (HSI), a biomarker for NAFLD, in early pregnancy subsequent GH PE. Objective: We aimed to investigate HSI risks PE Chinese women. Methods: Based on China Birth Cohort Study conducted from February 2018 December 2022, this...