Green technological innovation is one of the endogenous drivers green economic growth, and digitalization can promote development in form industrial empowerment. The interactive relationship degree influence between digitalization, innovation, thus an urgent issue to be addressed. Based on panel data 30 Chinese provinces from 2011 2019, we measured for first time using entropy method included them same analytical framework by constructing a PVAR model empirically test their interrelationship...

We present a novel deep network (namely BUSSeg) equipped with both within- and cross-image long-range dependency modeling for automated lesions segmentation from breast ultrasound images, which is quite daunting task due to (1) the large variation of lesions, (2) ambiguous lesion boundaries, (3) existence speckle noise artifacts in images. Our work motivated by fact that most existing methods only focus on within-image dependencies while neglecting dependencies, are essential this under...

Objective: The authors conducted a cost-effectiveness analysis incorporating recent phase III clinical trial (IMpassion130) data to evaluate the of atezolizumab in combination with nab-paclitaxel (AnP) against alone as first-line treatment for advanced triple-negative breast cancer developed and developing countries. Materials Methods: A decision-analytic Markov model was using IMpassion130 AnP over lifetime from US health care payer Chinese system perspective. Model inputs were derived...

Abstract Background Benign Paroxysmal Positional Vertigo (BPPV) is the commonest cause of vertigo in older adults. Due to its high incidence adults presenting with falls, vestibular assessment recommended World Guidelines for Falls Prevention. There a paucity evidence well conducted randomised controlled trials (RCTs) evaluate vitamin D prevention BPPV recurrence relation falls and function. Aims Primary outcome: does supplementation dietary interventions combination standard care impact...

Objective: To investigate the levels of insulin-like growth factor-1 (IGF-1) and receptor (IGF-1R) in serum placenta patients with preeclampsia (PE), establish their correlations, evaluate diagnostic potential. Methods: 22 PE normal pregnant women who underwent cesarean section deliveries at First Affiliated Hospital Guangxi Medical University between December 2021 2022 were included observation group control group. Enzyme-linked immunosorbent assay (ELISA) was utilized to measure IGF-1...

<title>Abstract</title> <bold>Purpose</bold> To comprehensively compare the risk of cardiotoxicity with 5-HT3RAs and to explore underlying pharmacokinetic factors that might partially contribute cardiotoxicity. <bold>Methods</bold> The FDA Adverse Event Reporting System (FAERS) data (January 2004 March 2023) were extracted. Disproportionality analysis by calculating relative odds ratio (ROR) sensitivity analyses conducted assess cardiac signals 5-HT3RAs. Additionally, various parameter...

Abstract Objective To determine if the recurrence rates of BPPV in older adults were lower vitamin D‐treated group as compared to placebo groups. Study Design Double‐blinded randomized control trial. Setting A single‐centre study. Methods controlled trial design with 12 months follow‐up. Vitamin D3 deplete participants into treatment (Group A) or groups B). Treatment received 13 weeks 2000 IU followed by 1000 for next weeks. Patients who replete allocated a C) observation and follow up. All...

Acupuncture has many advantages in the treatment of certain diseases as opposed to drug therapy. Besides, adenosine been revealed affect cellular progression including proliferation. Therefore, this study aimed at exploring mechanism involving acupuncture stress and fibroblast The fibroblasts from fascia tissues acupoint area (Zusanli) were stimulated by different levels stress, concentrations adenosine, agonist or antagonist A3 receptor (A3 R) investigate effect stimulation, adenosine-A3 R...

Combination therapy of zoledronic acid (ZOL) plus aromatase inhibitor (AI) was found to reduce bone metastasis risk and improve overall survival for treatment-naïve postmenopausal women (PMW) with hormone receptor-positive (HR+) early breast cancer (EBC), when compared AI alone. The objective this study evaluate the cost-effectiveness adding ZOL in treating PMW HR+ EBC China. A 5-state Markov model constructed PMW-EBC over a lifetime horizon from perspective Chinese healthcare provider. Data...

This study aimed to analyze the cost-effectiveness of combining screening for thiopurine methyl transferase (TPMT) and nucleotide triphosphate diphosphatase (NUDT15) defective alleles with therapeutic drug monitoring (TDM) in Chinese patients inflammatory bowel disease (IBD) treated azathioprine (AZA).We evaluated NUDT15 TPMT deficiency TDM receiving AZA treatment over a 1-year horizon by developing decision tree model. Real-world data published literature were used derive model inputs. The...

Abstract Purpose To investigate the cost‐effectiveness of lenvatinib plus pembrolizumab (LP) compared to chemotherapy as a second‐line treatment for advanced endometrial cancer (EC) from United States and Chinese payers' perspective. Methods In this economic evaluation, partitioned survival model was constructed perspective payers. The data were derived clinical trial (309‐KEYNOTE‐775), while costs utility values sourced databases published literature. Total costs, quality‐adjusted life...

Aim: To compare the cost–effectiveness of olaparib versus control treatment in metastatic castration-resistant prostate cancer patients with at least one gene mutation BRCA1, BRCA2 or ATM from US payer perspective. Methods: A Markov model was constructed to assess quality-adjusted life years (QALYs) and incremental ratios. Sensitivity analyses scenario were conducted explore impact uncertainties. Results: The base-case result indicated that, for specific mutations, gained 1.26 QALYs...

Background: Life expectancy for patients with malignant tumors has been significantly improved since the presence of programmed cell death protein-1/programmed protein ligand-1 (PD-1/PD-L1) inhibitors in 2014, but they impose heavy financial burdens patients, healthcare system and nations. The objective this study was to determine survival benefits, toxicities, monetary quantify their values. Methods: Randomized controlled trials (RCTs) PD-1/PD-L1 were identified clinical benefits quantified...

Abstract STUDY QUESTION Is it economically worthwhile to use GnRH agonist (GnRHa) prevent menopausal symptoms (MS) and protect fertility in premenopausal women with breast cancer (BC) during chemotherapy from the US perspective? SUMMARY ANSWER It is cost-effective administer GnRHa order forefend MS patients BC when willingness-to-pay (WTP) threshold $50 000.00 per quality-adjusted life-year (QALY), preserve young who undergo oocyte cryopreservation (OC), or no OC, WTP thresholds live birth...

Objective The S0226 trial demonstrated that the combination of half-dose fulvestrant (FUL) and anastrozole (ANA) (F&amp;A) caused a significant improvement in overall survival (OS) versus ANA monotherapy for first-line treatment postmenopausal women with hormone receptor-positive metastatic breast cancer (PMW-MBC (HR+)). objective this study was to evaluate cost-effectiveness F&amp;A PMW-MBC (HR+) China. Design We constructed Markov model over life-time horizon. clinical outcomes utility...

The aim of this study was to evaluate the disease burden prostate cancer (PC) and assess key influencing factors associated with expenditures PC in United States.The total deaths, incidence, prevalence, disability-adjusted life-years were obtained from Global Burden Disease Study 2019. Medical Expenditure Panel Survey used estimate healthcare productivity loss investigate patterns payment use resources States. A multivariable logistic regression model conducted identify expenditures.For...