A5026250880- Functional Brain Connectivity Studies
- Migraine and Headache Studies
- Advanced Neuroimaging Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Advanced MRI Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Spinal Dysraphism and Malformations
- Cardiovascular Syncope and Autonomic Disorders
- RNA and protein synthesis mechanisms
- Neuroscience of respiration and sleep
- Cerebral Venous Sinus Thrombosis
- Takotsubo Cardiomyopathy and Associated Phenomena
- Hereditary Neurological Disorders
- Metabolism and Genetic Disorders
- Biochemical effects in animals
- Psychosomatic Disorders and Their Treatments
- Amino Acid Enzymes and Metabolism
- Cerebrovascular and genetic disorders
- RNA regulation and disease
- Blood Pressure and Hypertension Studies
- Inflammasome and immune disorders
- Gout, Hyperuricemia, Uric Acid
- Neurological diseases and metabolism
- Moyamoya disease diagnosis and treatment
- Alcohol Consumption and Health Effects
Beijing Tian Tan Hospital
2015-2025
Capital Medical University
2014-2025
John Wiley & Sons (United States)
2023
Hudson Institute
2023
National Clinical Research Center for Digestive Diseases
2018-2022
Chinese Institute for Brain Research
2019-2021
Capital University
2021
Beijing Chest Hospital
2018
New daily persistent headache (NPDH) is a rare primary that highly disabling. The pathophysiology of NDPH still unclear, and we aimed to reveal the underlying mechanism through functional magnetic resonance imaging (fMRI) analysis.In this cross-sectional study, thirty patients with 30 healthy controls (HCs) were recruited. blood oxygen level-dependent (BOLD) sequences all participants obtained using GE 3.0 T system. We performed ReHo, ALFF (conventional band: 0.01-0.08 Hz, slow-5: 0.01-0.027...
Abstract Objective To explore whether MRI‐visible enlarged perivascular spaces (EPVS) are associated with migraine and may serve as a predictor of migraine. Then further its correlation chronification. Methods A total 231 participants (healthy control [HC] = 57, episodic [EM] 59, chronic [CM] 115) were included in this case–control study. 3T MRI device the validated visual rating scale used to assess grades EPVS centrum semiovale (CSO), midbrain (MB), basal ganglia (BG). Comparisons between...
Abstract Background New daily persistent headache (NDPH) is a rare primary disorder characterized by and sudden onset headaches. The pathogenesis of NDPH remains unclear, there are few white matter imaging studies related to NDPH. purpose this study was investigate the micro-structural abnormalities in provided insights into disease based on tract-based spatial statistics (TBSS). Methods Twenty-one patients with 25 healthy controls (HCs) were included study. T1 structural diffusion magnetic...
Abstract Background Preliminary evidence suggests that several headache disorders may be associated with glymphatic dysfunction. However, no studies have been conducted to examine the activity in migraine chronification. Purposes To investigate of chronification patients episodic (EM) and chronic (CM) using diffusion tensor image analysis along perivascular space (DTI-ALPS) method. Methods In this cross-sectional study, EM, CM, healthy controls (HCs) were included. All participants underwent...
The definitive pathogenic mechanisms underlying chronic migraine (CM) remain unclear. Mounting evidence from functional and structural magnetic resonance imaging (MRI) studies suggests that the caudate nucleus (CN) plays a role in cognitive, sensory, emotional integration of pain information patients with migraine. However, concerning played by CN CM is limited. Here, we used as seed to explore patterns connectivity (FC) among healthy controls (HCs), episodic (EM), CM.We included 25 HCs, 23...
New daily persistent headache (NDPH) and chronic migraine (CM) are two different types of headaches that might involve vascular dysregulation. There is still a lack clarity about altered brain perfusion in NDPH CM. This study aimed to investigate the cerebral variances CM using multi-delay pseudo-continuous arterial spin-labeled magnetic resonance imaging (pCASL-MRI).Fifteen patients with NDPH, 18 CM, 15 age- sex-matched healthy controls (HCs) were included. All participants underwent 3D...
The pathogenesis of new daily persistent headache (NDPH) is not fully understood. We aim to map aberrant functional connectivity (FC) in patients with NDPH using resting-state magnetic resonance imaging (MRI).Brain structural and MRI data were acquired from 29 37 well-matched healthy controls (HCs) this cross-sectional study. Region interest (ROI) based analysis was used compare FC between HCs, 116 brain regions the automated anatomical labeling (AAL) atlas defined as seeds. correlations...
New daily persistent headache (NDPH) is a rare but debilitating primary disorder that poses significant burden on individuals and society. Despite its clinical importance, the underlying pathophysiological mechanisms of NDPH remain unclear. In this study, we aimed to investigate brain structural changes neural activity patterns in patients with using multimodal imaging analysis magnetic resonance (sMRI) combined magnetoencephalography (MEG).Twenty-eight 37 healthy controls (HCs) were...
Abstract Objectives The new daily persistent headache (NDPH) is a rare primary disorder. However, the underlying mechanisms of NDPH remain incompletely understood. This study aims to apply seed‐based analysis explore functional connectivity (FC) brainstem nuclei in patients with using resting‐state magnetic resonance imaging (MRI). Methods FC from region interest (ROI) whole brain voxels was used investigate 29 and 37 well‐matched healthy controls (HCs) 3.0 Tesla MRI. 76 atlas were defined...
Abstract Background The pathogenesis of migraine chronification remains unclear. Functional and structural magnetic resonance imaging studies have shown impaired functional alterations in the brains patients with chronic migraine. cerebellum periaqueductal gray (PAG) play pivotal roles neural circuits pain conduction analgesia However, few neurotransmitter metabolism these migraine-associated regions been performed. To explore chronification, we measured gamma-aminobutyric acid (GABA)...
Abnormal iron deposition may be a biomarker for disrupted central antinociceptive neuronal network, and the relationship between pathophysiological mechanisms of chronic migraine (CM) with medication overuse (MOH) remains unclear. We investigated in deep gray matter (DGM) brain CM patients without MOH using quantitative susceptibility mapping (QSM). Forty-eight healthy controls (HCs) 69 (36 MOH; 33 MOH) were recruited. QSM data acquired 3.0 T Magnetic resonance imaging (MRI). Regions...
To explore gamma-aminobutyric acid (GABA) and glutamate/glutamine (Glx) levels in the right thalamus of patients with episodic migraine (EM) chronic (CM) their effects on chronification migraine.Migraine affects approximately 1 billion people worldwide, 2.5%-3% EM progressing to CM each year. Magnetic resonance spectroscopy studies have revealed altered GABA Glx without aura, but these neurometabolic concentrations are underexplored CM.In this cross-sectional study, were recruited....
Background and objective: Cerebral autosomal-dominant arteriopathy with subcortical infarcts leukoencephalopathy (CADASIL) is the best known most common monogenic small vessel disease (SVD). Cognitive impairment an inevitable feature of CADASIL. Total SVD score global cortical atrophy (GCA) scale were found to be good predictors poor cognitive performance in community-dwelling adults. We aimed estimate association between total score, GCA patients Methods: enrolled 20 genetically confirmed...
Background: The mechanism of obesity paradox in stroke is not clear. This study aimed to investigate whether uric acid (UA) contributes obesity-stroke outcome paradox. Material and Methods: cohort consisted 1,984 IS patients recruited the ACROSS-China study. Serum UA BMI were measured at admission. Low high groups defined by threshold 24, low age- sex-specific median. Poor outcomes as modified Rankin scale score ≥3 1 year after onset. Results: was significantly positively correlated with...
To determine the novel AARS2 mutation implicated in leukodystrophy, this study, several families with an autosomal recessive inheritance pattern of leukodystrophy were analyzed by whole-exome sequencing. Variants prioritized according to their rarity and those pathogenic variants genes already known be associated confirmed Sanger sequencing using standard protocols. We identified 5 rare (c.452T>C chr6:44279256 p.M151T, c.1871G>A chr6:44272054 p. W624X, c.802A>G chr6:44278128 p.M268V,...
Abstract Background The brain functional network topology in new daily persistent headache (NDPH) is not well understood. In this study, we aim to assess the cortical topological characteristics of NDPH using non-invasive neural signal recordings. Methods Resting-state magnetoencephalography (MEG) was used measure power fluctuations neuronal oscillations from distributed parcels 35 patients with and 40 healthy controls (HCs). Their structural data were collected by 3T MRI. Functional...
Whether cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a risk factor for spontaneous intracerebral hemorrhage (ICH) influences outcomes remains unclear. In this study, we report two cases of CADASIL presenting hemorrhages. These suggest that vasculopathy by itself mainly results in ICH, as indicated slight vascular factors prominent neuroimaging abnormalities, suggesting should be considered ICH. Interestingly, decreased perihematomal...
New daily persistent headache (NDPH) is a rare primary disorder characterized by and sudden onset headaches. Specific abnormalities in gray matter white structure are associated with pain, but have not been well studied NDPH. The objective of this work to explore the fiber tracts structural connectivity, which can help reveal unique regional radiomics similarity networks were calculated from T1 weighted (T1w) MRI depict structure. connectivity matrices diffusion metrics like fractional...
To delineate the structural connectome alterations in patients with chronic migraine (CM), episodic (EM), and healthy controls (HCs). The pathogenesis of chronification remains elusive, brain network changes potentially playing a key role. However, there is paucity research employing graph theory analysis to explore whole networks CM EM. individual 60 CM, 34 EM, 39 control participants were constructed by using deterministic diffusion-tensor tractography. Graph metrics including global...
Glycyl-tRNA synthetase (GARS) gene mutation have been reported to be associated with Charcot-Marie-Tooth disease 2D (CMT2D) and distal hereditary motor neuropathy type V (dHMN-V). Here, we report a novel GARS in Chinese family dHMN-V. Clinical, electromyogram, genetic functional data were explored. The proband was an eleven-year-old girl presented progressive limb muscle weakness atrophy due peripheral for one year. Another 5 members from three successive generations of the showed similar...
Amygdala, an essential element of the limbic system, has served as important structure in pain modulation. There is still a lack clarity about altered cerebral perfusion amygdala migraine. This study aimed to investigate variances bilateral episodic migraine (EM) and chronic (CM) using multi-delay pseudo-continuous arterial spin-labeled magnetic resonance imaging (pCASL-MRI).Twenty-six patients with EM, 55 CM (33 medication overuse headache (MOH)), 26 age- sex-matched healthy controls (HCs)...
Multifocal atherosclerosis has dramatically increased annual risk of adverse cardiovascular events than single artery affected. Triglyceride-rich lipoprotein (TRL) been implicated in the early development atherosclerosis.However, evidence on effect remnant cholesterol, a major atherogenic component TRL, multifocal Chinese health asymptomatic subjects is insufficient. This study aimed to investigate association cholesterol with intra- and extra-cranial population.This enrolled 3665...