A5080036564- Acute Ischemic Stroke Management
- Catalytic Processes in Materials Science
- Cerebrovascular and Carotid Artery Diseases
- Lipoproteins and Cardiovascular Health
- Catalysis and Oxidation Reactions
- Industrial Gas Emission Control
- Antiplatelet Therapy and Cardiovascular Diseases
- Catalysis and Hydrodesulfurization Studies
- Neurological Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Stroke Rehabilitation and Recovery
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Aquaculture Nutrition and Growth
- Diabetes Treatment and Management
- Gas Sensing Nanomaterials and Sensors
- Cancer, Lipids, and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Heart Rate Variability and Autonomic Control
- Reproductive biology and impacts on aquatic species
- Aquatic life and conservation
- Intracerebral and Subarachnoid Hemorrhage Research
- Microbial Community Ecology and Physiology
- Nutritional Studies and Diet
Beijing Tian Tan Hospital
2019-2024
Capital Medical University
2019-2024
Guangxi University
2023-2024
Zhejiang Ocean University
2023-2024
Zhejiang University
2023-2024
Beijing Anzhen Hospital
2024
Ministry of Ecology and Environment
2023-2024
National University of Defense Technology
2023
National Clinical Research Center for Digestive Diseases
2019-2022
Chinese Institute for Brain Research
2019-2021
Hemodynamic impairment of blood pressure may play a crucial role in determining the mechanisms stroke symptomatic intracranial atherosclerotic stenosis). We aimed to elucidate this issue and assess impacts modifications on hemodynamic impairment.
Background: Although wall shear stress (WSS) and pressure play important roles in plaque vulnerability, characteristics of the two indices intracranial atherosclerosis (ICAS) have not been fully investigated yet. This study aimed to elucidate this issue by means establishing a non-invasive computational fluid dynamics method with time-of-flight magnetic resonance angiography (TOF-MRA) whole cerebral artery. Materials Methods: Subjects symptomatic ICAS middle artery domain were enrolled,...
During the acute stage of ischemic stroke, it remains unclear how to interpret low low-density lipoprotein cholesterol (LDL-C) level. We aimed evaluate association between LDL-C levels, post-stroke infection, and all-cause mortality. 804,855 stroke patients were included. Associations mortality risk estimated by multivariate logistic regression models displayed restricted cubic spline curves. Mediation analysis was performed under counterfactual framework elucidate mediation effect...
Abstract At present, large yellow croaker, Larimichthys crocea , a carnivorous fish ranked fifth in aquaculture production among marine finfishes the world, still relies on raw diet because formulated feed alone is not able to sustain rapid growth of fish. The present study evaluated growth, utilization efficiency, body composition and antioxidant capacity croaker fed diets containing four protein (430, 460, 490 520 g/kg) three lipid (60, 90 120 levels. Fish weighing 11.4 ± 2.8 g were with...
Although essential for cardiovascular therapy, the pleiotropic effects of statins on ischemic stroke lack clinical evidence. This study examined beyond low-density lipoprotein cholesterol (LDL-C) levels mortality and severity. A total 825,874 patients with were included in this study, whom 125,650 statin users 1:1 matched non-users based their LDL-C (±0.05 mmol/L), forming LDL-C-matched cohort. Associations between preceding treatment, in-hospital mortality, severity (National Institutes...
Objective Dual antiplatelet therapy (DAT) with clopidogrel plus aspirin has been suggested by American Heart Association/American Stroke Association guidelines for minor stroke (MS) and transient ischemic attack (TIA) patients. The purpose of this study was to find the potential subgroups that benefit from DAT. We aimed compare efficacy clopidogrel–aspirin in MS/TIA patients stratified CYP2C19 genotype risk profiles. Methods loss‐of‐function allele (LoFA) carriers were defined as LoFA either...
Infection occurs commonly in patients with acute ischemic stroke. We aimed to investigate the association of infection short- and long-term risk recurrent stroke stroke.Data were derived from 2 registries: CSCA (Chinese Stroke Center Alliance) program recorded medical data during hospitalization, CNSR-III (Third China National Registry) hospitalization finished 1-year follow-up. Associations (pneumonia or urinary tract infection) short (during hospitalization) long term (since 30 days 1 year...
Objectives Incident ischaemic stroke (IS) risk may increase not only with lipids concentration but also longer duration of exposure. This study aimed to investigate the impact cumulative burden lipid profiles on incident IS. Methods A total 43 836 participants were enrolled who participated in four surveys during 2006–2013. Individual was calculated as number years (2006–2013) multiplied by levels low-density lipoprotein cholesterol (LDL-C), (TC), high-density (HDL-C), non-HDL-C and...
Previously, the CANTOS (Canakinumab antiinflammatory Thrombosis Outcome Study) targeting residual inflammatory risk demonstrated that therapy significantly reduces rate of recurrent cardiovascular events independent decreases in lipid levels [7].This is agreement with pathophysiological viewpoint atherosclerosis a disorder involving both hyperlipidemia and inflammation [8].Moreover, meta-analysis confirmed high sensitivity C-reactive protein (hs-CRP) LDL-c similarly predict vascular [9].Such...
Background and purpose The Treat Stroke to Target trial has confirmed the benefit of targeting low-density lipoprotein cholesterol (LDL-C) <1.8 mmol/L in patients who had an ischaemic stroke (IS). However, haemorrhagic risk brought by this target level (<1.8 mmol/L) or even lower (<1.4 LDL-C should also be concerned. In study, we aimed demonstrate whether low could increase intracranial haemorrhage following IS. Methods Patients IS from China Center Alliance programme with complete...
Background: Interleukin-6 (IL-6) plays an important role in the pathophysiology of atherosclerosis. This study aimed to determine whether IL-6 is a crucial biomarker associated with Multiple Acute Infarctions (MAIs), which indicate stroke mechanism artery-- to-artery embolism high risk recurrence symptomatic Intracranial Atherosclerotic Disease (sICAD). We tested association between circulating levels and presence MAIs prospective population-based registry. Methods: included 1,919 patients...
Background and Purpose: The age, body mass index, chronic kidney disease, diabetes, genotyping (ABCD-GENE) score is a validated risk integrating CYP2C19 genotypes with clinical factors influencing clopidogrel response that would allow the more precise identification of subjects at for high platelet reactivity adverse outcomes. Our objective was to further verify application ABCD-GENE investigate appropriate cutoff value in patients minor stroke or transient ischemic attack. Methods: In this...
Background and Purpose— The role of dual-antiplatelet therapy with clopidogrel plus aspirin has been demonstrated to substantially decrease the risk recurrent stroke among patients minor transient ischemic attack. We aimed determine whether efficacy clopidogrel-aspirin / attack was influenced by stratification CYP2C19 genotype body mass index (BMI). Methods— loss-of-function allele (LoFA) carriers were defined as either LoFA *2 or *3. Low/normal weight overweight/obesity BMI <25 ≥25 kg/m...
Abstract High blood pressure (BP) is frequent in acute ischemic stroke (IS). However, the impact of BP change patterns during phase on clinical outcomes not conclusive. This study aims to investigate association between acute‐phase trajectories and IS patients with high admission BP. The cohort consisted 316 systolic (SBP) ≥160 mm Hg. SBP first 7 days after onset were characterized using a random effects model. classified into three groups based trajectory curve parameters: sustained (T1),...
Background: The mechanism of obesity paradox in stroke is not clear. This study aimed to investigate whether uric acid (UA) contributes obesity-stroke outcome paradox. Material and Methods: cohort consisted 1,984 IS patients recruited the ACROSS-China study. Serum UA BMI were measured at admission. Low high groups defined by threshold 24, low age- sex-specific median. Poor outcomes as modified Rankin scale score ≥3 1 year after onset. Results: was significantly positively correlated with...
Objectives To establish a new ambulatory blood pressure (ABP) parameter (24-hour ABP profile) and evaluated its performance on stroke outcome in ischaemic (IS) or transient attack (TIA) patients. Methods The prospective cohort consisted of 1996 IS/TIA patients enrolled for monitoring 3-month follow-up recurrence as outcome. Profile groups systolic (SBP) were identified via an advanced functional clustering method, the associations profile conventional parameters with examined Cox...
This study aimed to demonstrate the impact of cumulative burden cardiovascular risk factors (CVRFs) on events (CVEs). A total 34 959 participants were enrolled who participated in four surveys during 2006-2013. Cumulative CVRF was calculated as number years (2006-2013) multiplied by values CVRFs including systolic blood pressure, fasting glucose (FBG), low-density lipoprotein cholesterol (LDL-C), and high-sensitive C-reactive protein (hs-CRP). The primary outcome defined CVE 2012-2017,...
Objective: Serum cystatin C (CysC) is a sensitive marker of renal function to predict cardiovascular diseases. We aimed investigate the predictive value CysC for clinical outcomes independent in patients with acute ischemic stroke (AIS). Methods: measured serum levels 10,256 AIS from Third China National Stroke Registry (CNSR-III). The primary outcome was combination all-cause mortality and major disability (modified Rankin scale score, 3–6). Secondary included recurrence combined vascular...