A5100376294- Acute Ischemic Stroke Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Blood Pressure and Hypertension Studies
- Lipoproteins and Cardiovascular Health
- EEG and Brain-Computer Interfaces
- Cardiovascular Health and Risk Factors
- Fluid Dynamics and Turbulent Flows
- Gout, Hyperuricemia, Uric Acid
- Neurological Disease Mechanisms and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Cancer, Lipids, and Metabolism
- Epilepsy research and treatment
- Venous Thromboembolism Diagnosis and Management
- Liver Disease Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Sleep and related disorders
- Peripheral Artery Disease Management
- Renal cell carcinoma treatment
- Ginkgo biloba and Cashew Applications
- Cancer Immunotherapy and Biomarkers
- Cardiovascular Function and Risk Factors
- Particle Dynamics in Fluid Flows
- Alcohol Consumption and Health Effects
Qilu Hospital of Shandong University
2025
Capital Medical University
2020-2025
Beijing Tian Tan Hospital
2021-2025
Tianjin University
2024-2025
Sun Yat-sen University Cancer Center
2017-2025
Beijing Institute of Neurosurgery
2024-2025
Sun Yat-sen University
2017-2025
Tianjin People's Hospital
2013-2024
National Clinical Research Center for Digestive Diseases
2021-2024
First Affiliated Hospital Zhejiang University
2016-2024
Abstract Aims Whereas cardiovascular disease (CVD) metrics define risk in individuals aged over 40 years, the earliest lesions of CVD appear well before this age. Cardiovascular health (CVH) was proposed to improve factors and updated recently. This study aimed explore associations baseline long-term CVH assessed by ‘Life’s Essential 8’ with premature all-cause mortality young Chinese adults. Methods results A total 16 011 CVD-free participants 18–40 years were enrolled from Kailuan cohort...
DL-3-n-butylphthalide (NBP) is a drug for treating acute ischemic stroke and may play neuroprotective role by acting on multiple active targets. The efficacy of NBP in patients with receiving reperfusion therapy remains unknown. To assess the safety intravenous thrombolysis and/or endovascular treatment. This multicenter, double-blind, placebo-controlled, parallel randomized clinical trial was conducted 59 centers China 90-day follow-up. Of 1236 stroke, 1216 18 years older diagnosed National...
Background The locus for familial cortical myoclonic tremor with epilepsy (FCMTE) has long been mapped to 8q24 in linkage studies, but the causative mutations remain unclear. Recently, expansions of intronic TTTCA and TTTTA repeat motifs within SAMD12 were found be involved pathogenesis FCMTE Japanese pedigrees. We aim identify Chinese Methods performed genetic analysis by microsatellite markers a five-generation pedigree 55 members. also used array-comparative genomic hybridisation (CGH)...
Whether the combination of different blood pressure and arterial stiffness (AS) status is independently associated with diabetes has not been fully investigated so far. This study aimed at investigating hypertension AS in determining diabetes.This prospective cohort included 11 156 participants from Kailuan study. was measured by brachial-ankle pulse wave velocity. We compared risk between individuals ideal vascular function (defined as normotension normal AS), elevated AS, AS.After a median...
Abstract Background Serum albumin to globulin ratio (A/G) has been widely used as a representative biomarker for assessing inflammation and nutrition status. However, in patients with acute ischemic stroke (AIS), the predictive value of serum A/G rarely reported. We aimed evaluate whether is associated prognosis stroke. Methods analyzed data from Third China National Stroke Registry. The were categorized into quartile groups according at admission. Clinical outcomes included poor functional...
Abstract Background Atherogenic index of plasma (AIP) has been confirmed as a novel marker for myocardial infarction (MI), but few evidence on the long-term AIP and MI risk in general populations. We thus aimed to evaluate relationships cumulative exposure its accumulation time course with MI. Methods A total 54,440 participants were enrolled Kailuan study. Time-weighted was calculated weighted sum mean value each interval, then normalized by duration, duration from 2006 2010. Duration high...
Hendra virus (HeV) and Nipah (NiV) are closely related emerging viruses comprising the Henipavirus genus of Paramyxovirinae. Each has a broad species tropism can cause disease with high mortality in both animal human hosts. These infect cells by pH-independent membrane fusion event mediated their attachment (G) (F) envelope glycoproteins (Envs). Seven Fabs, m101 to -7, were selected for significant binding soluble form G (sG) which was used as antigen panning large naïve antibody library....
Abstract Background The mechanisms linking obesity to cardiovascular disease (CVD) are still not clearly defined. Individuals who overweight or obese often develop insulin resistance, mediation of the association between and CVD through resistance seems plausible has been investigated. This study aimed evaluate whether what extend effect general central on is mediated by resistance. Methods A total 94,136 participants without at baseline were recruited from Kailuan study. Insulin was...
Importance Ginkgo diterpene lactone meglumine (GDLM) has attracted much attention because of its potential neuroprotective properties in ischemic stroke. The efficacy GDLM patients with acute stroke (AIS) needs to be verified by well-designed randomized clinical trials. Objective To assess the and safety AIS. Design, Setting, Participants This multicenter, randomized, double-blind, placebo-controlled, parallel-group trial involved 3448 who had AIS, were aged 18 80 years, a clinically...
The risk of cardiovascular disease (CVD) depended on the magnitude and exposure duration insulin resistance (IR). This study aimed to investigate associations cumulative metabolic score for IR (cumMETS-IR) with incident CVD, further explore modulated effects time course METS-IR accumulation.
Worldwide, the incidence of colorectal cancer (CRC) continues to rise and remains a major public health concern. This study aimed analyze temporal spatial trends in CRC related risk factors at country level.
The identification and characterization of new human monoclonal antibodies (hMAbs) able to neutralize primary immunodeficiency virus type 1 (HIV-1) isolates from different subtypes may help in our understanding the mechanisms entry neutralization development inhibitors vaccines. For enhanced selection broadly cross-reactive antibodies, soluble HIV-1 envelope glycoproteins (Envs proteins) two complexed with two-domain CD4 (sCD4) were alternated during panning a phage-displayed antibody...
This article aims to summarize a series of contingency management strategies the Nursing Department in centralized treatment patients with coronavirus disease 2019 (COVID-19). The included an early warning for prevention and control, taking functions vertically commanding horizontally coordinating, reasonably allocating nursing workforce, facilitate work in-hospital fever clinic, isolation wards ICU, referral admission critical patients. Five special groups were established charge training...
Background and Purpose Previous studies suggested increased visit-to-visit variability of total cholesterol (TC) is associated with stroke. This study aimed to investigate the associations various lipids measurements risk stroke type (ischemic hemorrhagic stroke).Methods Fifty-one thousand six hundred twenty participants in Kailuan Study without history myocardial infarction, stroke, cancer who underwent three health examinations during 2006 2010 were followed for incident Variability TC,...
Abstract Background Risk profiles for premature cardiovascular disease (CVD) are unclear. This study aimed to examine baseline risk incident CVD by age at onset in Chinese population. Methods A total of 97,841 participants without were enrolled from the Kailuan cohort study. Four groups examined (< 55, 55 < 65, 65 75, and ≥ 75 years) onset. included clinical, lipid, metabolic, inflammatory factors biomarkers. Results Of clinical factors, diabetes was associated with highest relative...
Background The American Heart Association recently proposed an updated definition of cardiovascular health (CVH) named as Life's Essential 8. We aimed to explore the association between this latest published CVH measurement and years lived without disease (CVD) among Chinese population. Methods Results included 89 755 adults free CVD at baseline from Kailuan study. each participant was scored (from 0 point 100 points) classified (low [0–49 points], moderate [50–79 high [80–100 points])...
Background Healthy individuals with normal level of serum uric acid (SUA) may not be truly at the lowest risk cardiovascular disease (CVD). This study aimed to assess association SUA levels CVD and its subtypes in people without factors determine a suitable target prevent CVD. Methods Results We enrolled 25 284 participants who were free CVD, absent factors, an between 180 359 μmol/L (3–6 mg/dL) baseline from Kailuan study. Cox proportional hazards models applied calculated adjusted hazard...
Abstract Objective The objective of this study was to evaluate the associations general and central obesity with risk first cardiometabolic disease (FCMD), multimorbidity (CMM), death. Methods A total 86,169 participants who were CMD‐free included from Kailuan cohort categorized into four groups by quartiles BMI, waist hip ratio (WHR), weight‐adjusted index, height ratio. We defined FCMD as onset diabetes, stroke, or myocardial infarction CMM co‐occurrence at least two CMDs. Multistate...
Antibody-dependent cell-mediated cytotoxicity (ADCC) bridges innate and adaptive immunity, it involves both humoral cellular immune responses. ADCC has been found to be a main route of protection against viral infections in vivo. Hemagglutinin (HA) influenza virus is highly immunogenic considered the most important target for protection. Several potent cross-reactive HA-specific neutralizing monoclonal antibodies (MAbs) have reported, their conserved epitopes revealed, but there no report so...
Levodopa remains the gold standard for treatment of Parkinson's disease, but its long-term use is associated with motor complications whose management still a significant challenge. Safinamide multimodal drug proven efficacy as an adjunct to levodopa. The objective this study was investigate and safety safinamide add-on levodopa in Chinese patients disease fluctuations. XINDI phase III, randomized, double-blind, placebo-controlled, multicenter study, 2-week screening period 16-week period....
Abstract Conventional imaging examinations are not sensitive enough for the early detection of recurrent or metastatic lesions in renal cell carcinoma (RCC) patients. We aimed to explore role 68 Ga‐prostate specific membrane antigen (PSMA)‐11 positron emission tomography (PET)/computed (CT) primary and such retrospectively analyzed 50 RCC patients who underwent Ga‐PSMA‐11 PET/CT from November 2017 December 2020. observed a higher median accuracy tumor‐to‐background maximum standard uptake...
Inflammation plays an important role in the pathological progress associated with stroke. Serum uric acid (SUA) to lymphocyte ratio (ULR), a novel inflammatory biomarker, has been considered as better risk stratification tool of adverse outcomes than SUA or alone. This study aimed investigate whether ULR produced more predictive value for stroke and explore potential mediators associations.This enrolled 93,023 Chinese participants without myocardial infarction at baseline. Cox proportional...
Aims: Studies showed that low-density lipoprotein cholesterol (LDL-C) to triglyceride (TG) ratio could be used as a predictive parameter of oxidation in vivo and the level small dense LDL-C. However, whether LDL-C/TG is associated with stroke prognosis remains unclear. We investigated associations outcomes patients acute ischaemic (AIS) or transient attacks (TIA) explored it produced more value than LDL-C TG.