A5086701414- Oxidative Organic Chemistry Reactions
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Vanadium and Halogenation Chemistry
- Catalytic C–H Functionalization Methods
- Chemical Synthesis and Reactions
- Cyclopropane Reaction Mechanisms
- Asymmetric Synthesis and Catalysis
- Sulfur-Based Synthesis Techniques
- Chemical Synthesis and Analysis
- Catalytic Alkyne Reactions
- Organoselenium and organotellurium chemistry
- Click Chemistry and Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Supramolecular Self-Assembly in Materials
- Crystallography and molecular interactions
- Fuel Cells and Related Materials
- Catalysis and Oxidation Reactions
- Synthesis and Catalytic Reactions
- Catalysis and Hydrodesulfurization Studies
- Nanomaterials for catalytic reactions
- Copper-based nanomaterials and applications
- SARS-CoV-2 and COVID-19 Research
- Asymmetric Hydrogenation and Catalysis
- Advanced biosensing and bioanalysis techniques
Chinese University of Hong Kong
2013-2025
Chinese University of Hong Kong, Shenzhen
2022-2025
Chemical Synthesis Lab
2025
State Key Laboratory of Synthetic Chemistry
2011-2021
Shatin Hospital
2018-2020
National University of Singapore
2013-2015
University Grants Committee
2013
Institute of Molecular Functional Materials
2011-2013
Sun Yat-sen University
2007-2008
State Key Laboratory of Rare Earth Materials Chemistry and Application
2007
An enantioselective and highly diastereoselective bromoetherification desymmetrization of olefinic 1,3-diols has been developed using a C2-symmetric cyclic sulfide catalyst. This methodology successfully applied to the synthesis key intermediate an orally active antifungal drug posaconazole (Noxafil).
The use of trisubstituted selenonium salts as organic Lewis acids in electrophilic halogenation and aldol-type reactions has been developed. substrate scope is broad. reaction conditions are mild compatible with various functionalities. This study opens a new avenue for the development nonmetallic acid catalysis.
The lethality and chemotherapy resistance of pancreatic cancer necessitates the urgent development innovative strategies to improve patient outcomes. To address this issue, we designed a novel drug delivery system named GDMCN2,which uses iron-based metal organic framework (Fe-MOF) nanocages encased in covalent (COF) modified with cancer-specific antibody, NRP2. After being targeted into tumor cells, GDMCN2 gradually release sonosensitizer sinoporphyrin sodium (DVDMS) chemotherapeutic...
A series of platinum(II) terpyridine complexes with L-valine-modified alkynyl ligands has been synthesized. complex an unsubstituted and one valine unit on the is shown to be capable gel formation, which in sharp contrast gelation properties corresponding organic counterparts. Upon sol-gel transition, a drastic color change from yellow red observed, indicative involvement Pt⋅⋅⋅Pt interactions. Through concentration- temperature-dependent UV/Vis absorption, emission, circular dichroism, (1) H...
Selenofunctionalization is used for the introduction of aryl- or alkylseleno moieties, which can then be transformed into other functional groups (such as alkenes and carbonyls). However, asymmetric selenofunctionalization unactivated olefins often difficult to realize, cations rapidly interchange between olefinic partners. Recently, it has been demonstrated that Lewis bases, assisted by Brønsted acids, induce high levels enantioselectivity in selenocyclization reactions. The acid serves an...
Lewis acids are frequently employed in catalysis but they often suffer from high moisture sensitivity. In many reactions, catalysts deactivated because of the problem that strong also bond to products. this research, hydrolytically stable bidentate acid derived selenonium dicationic centers have been developed. The bis-selenonium activation imine and carbonyl groups various transformations with good yields selectivity. acidity salts was found be stronger than monoselenonium systems,...
Platinum (Pt) is a state-of-the-art electrocatalyst for green hydrogen production in alkaline electrolytes. The delicate design and fabrication of two-dimensional (2D) Pt nanocatalysts can significantly enhance atomic utilization efficiency, while further improving intrinsic catalytic performance by modulating the density surface active sites. However, high energy morphology complexity 2D nanostructures often result poor structural stability under working conditions. Here, we report...
This Feature Article gives a summary on the conformational and supramolecular properties of special type click molecules, namely, main chain cyclic oligo- polytriazoles. The triazole ring is an interesting structural motif since it hydrogen bond donor acceptor, large molecular dipole also metal ligand. It can interact with wide variety functionalities, e.g. bonding partners (e.g. amides or anions), dipoles, ions to generate many fascinating features such as pseudo rod-like, U-turn, helical,...
Abstract A facile and effective system has been developed for the regio‐ chemoselective ring‐opening/electrophilic functionalization of cyclopropanes through C−C bond activation by [bis(trifluoroacetoxy)iodo]benzene with aid Lewis basic promoter p ‐toluenesulfonamide. The ‐toluenesulfonamide‐promoted works well a wide range cyclopropanes, resulting in formation 1,3‐diol products good yields regioselectivity.
ZnO nanoporous structures were prepared on Cu substrates by electrochemical deposition in solutions of ZnCl2 + ethylenediaminetetraacetic acid (EDTA) at a temperature 90 °C. Cyclic voltammetry was used to study the reactions relevant film growth. The transfer coefficient and diffusion Zn(II) 0.05 mol L-1 0.01 EDTA 343 K calculated as 0.276 5.12 × 10-10 m2 s-1, respectively. synthetic parameters this research allowed further structural manipulation for films. morphology evolvement from...
A Lewis basic sulfide catalyzed electrophilic bromocyclization of cyclopropylmethyl amide has been developed. The catalytic protocol is applicable to both 1,1- and 1,2-substituted amides, giving oxazolines oxazines in good yields excellent diastereoselectivity.
Abstract A proof‐of‐concept study of hypervalent chalcogenonium⋅⋅⋅π bonding catalysis was performed. new catalytic strategy using 1,2‐oxaselenolium salts as chalcogen bond donors and alkenes acceptors is described. The feasibility this concept demonstrated by the use trisubstituted selenonium in metal‐free hydrofunctionalization polymerization via unconventional seleniranium ion‐like intermediates. results indicate that counter anions have a significant effect on based interactions.
Click triazole-based oligopeptides 1–3 were found to self-dimerize (Kdim ≈ 10–680 M–1) in a head-to-tail fashion based on 1H variable concentration, 2D, and H/D exchange NMR, VPO, CD, FT-IR studies Gaussian 03 simulations. The dimerization constant Kdim was shown increase with increasing number of the amino acid units. Within same oligomeric series, value is strongly affected by size C-terminal end group. tripeptides 2 are also excellent organogelators aromatic solvents.
Abstract A highly facile and efficient electrophilic bromolactonization of cyclopropylcarboxylic acids could be effected by a Lewis basic sulfide catalyst. Mechanistic studies performed revealed that the cyclopropane substrates undergo radical bromination upon exposure to light, yielding mixture regioisomers. In stark contrast, catalyst promote yield Markovnikov product exclusively. magnified image
Non-symmetrical bromoiodanes are useful for bromination reactions, and some protocols were found to be suitable specific substrates. Herein, we report the use of a DIB/BBr3 protocol various including electrophilic arenes, carbonyl C–H monobromination, bromolactonization, bromocarbocyclization, intermolecular bromoetherification olefin, light-triggered C(sp3)–H bromination.
Position-selective halogenation of thioarenes and a wide range aromatics using highly lipophilic indole organocatalyst has been developed.
Abstract An efficient and regioselective electrophilic bromolactonization of cyclopropylmethyl diesters using triphenylphosphine sulfide (Ph 3 PS) or diphenyl selenide 2 Se) as the Lewis basic chalcogenide catalyst has been developed. It was observed that Ph PS favored formation anti ‐diastereomer yielded multi‐functional γ‐lactones. Interestingly, diastereoselectivity reversed when Se a where syn ‐product instead favored. magnified image
α,α-Dihalo-N-arylacetamides are commonly used as intermediates in various organic reactions. In the study described here, a catalytic synthesis of α,α-dihalo-N-arylacetamides from β-oxo amides was developed using zwitterionic catalysts and N-halosuccinimides halogen sources. The corresponding were obtained good to excellent yields, no aromatic halogenated side products detected. reaction conditions mild, strong base or acid required.