A5021321101- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Ocular Oncology and Treatments
- Immunodeficiency and Autoimmune Disorders
- Chronic Myeloid Leukemia Treatments
- Glioma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Multiple Myeloma Research and Treatments
- Cancer Genomics and Diagnostics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Protein Degradation and Inhibitors
- Genetic factors in colorectal cancer
- Genetics and Neurodevelopmental Disorders
- Chromatin Remodeling and Cancer
- Cancer and Skin Lesions
- Cutaneous Melanoma Detection and Management
- Cervical Cancer and HPV Research
- Cell death mechanisms and regulation
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- Epigenetics and DNA Methylation
- Genital Health and Disease
- Lung Cancer Research Studies
Istituto Oncologico Veneto
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2024
Molecular Oncology (United States)
2021-2024
Colorado Blood Cancer Institute
2023
Sarah Cannon
2023
University of Padua
1996-2017
University of Verona
2017
University of Campania "Luigi Vanvitelli"
2017
Veneto Institute of Molecular Medicine
2016
Azienda Ospedaliera di Padova
1996-2006
Purpose To date, no data are available on the relationship between 1p/19q deletions and response to temozolomide (TMZ) in primary anaplastic oligodendroglioma (AO) oligoastrocytoma (AOA) recurrent after surgery standard radiotherapy. The aim of this study was evaluate correlations deletions, O6-methylguanine DNA methyltransferase (MGMT) promoter methylation, rate TMZ setting. Patients Methods From June 2000 February 2005, 67 patients were enrolled; 39 (58%) had AO 28 (42%) AOA. All received...
In-depth characterization of recurrent glioblastoma (rGBM) might contribute to a better understanding the mechanisms behind tumor progression and enable rGBM treatment with targeted drugs.Experimental Design: In this study, GBM samples were collected at diagnosis recurrence from adult patients treated Stupp protocol. Expression mismatch repair (MMR) proteins was evaluated by IHC, followed whole exome sequencing (WES) showing loss MSH6 reactivity. Established genetic, epigenetic, immunologic...
Complex karyotype (CK) at chronic lymphocytic leukemia (CLL) diagnosis is a negative biomarker of adverse outcome. Since the impact CK and its subtypes, namely type-2 (CK with major structural abnormalities) or high-CK ≥5 chromosome abnormalities), on risk developing Richter syndrome (RS) unknown, we carried out multicenter real-life retrospective study to test prognostic impact. Among 540 CLL patients, 107 harbored diagnosis, 78 were classified as CK2 52 high-CK. Twenty-eight patients...
Background B-cell chronic lymphocytic leukemia is a clinically heterogeneous disease; some patients rapidly progress and die within few years of diagnosis, whereas others have long life expectancy with minimal or no treatment. Telomere length telomerase levels been proposed as prognostic factors; however, very cases characterized for both parameters study has analyzed the value telomere/telomerase profile.Design Methods One hundred seventy-three were telomere lengths by real-time polymerase...
Abstract Background The involvement of protein kinase CK2 in sustaining cancer cell survival could have implications also the resistance to conventional and unconventional therapies. Moreover, role blood tumors is rapidly emerging this has been recognized as a potential therapeutic target. Phase I clinical trials with oral small ATP-competitive inhibitor CX-4945 are currently ongoing solid multiple myeloma. Methods We analyzed expression acute myeloid leukemia its function growth response...
Summary Complex karyotype ( CK ) is a negative prognostic factor in chronic lymphocytic leukaemia CLL ). However, heterogeneous cytogenetic category. Unbalanced rearrangements were present 73·3% of 90 patients with (i.e. ≥3 chromosome aberrations the same clone), and associated shorter overall survival P = 0·025) time to first treatment 0·043) by multivariate analysis. Patients unbalanced presented distinct mRNA expression profile. In conclusion, might represent subset very high‐risk...
Complex karyotype (CK) is a heterogeneous category with negative impact in chronic lymphocytic leukaemia (CLL). Our group has recently reported that CK patients major structural abnormalities (i.e. CK2) are characterised by worse prognosis, as compared to other lesions within CK(CK1).We performed multicentre retrospective study test whether the combination of subtypes IGHV status could be relevant prognostic and predictive tool.Among 522 13% harboured CK2, 41% CK1 and/or U-IGHV (U-CK1) 46%...
Purpose Cytogenetic prognostication of choroidal melanoma, particularly monosomy 3 detections, is limited to enucleated eyes or resected tumors. The authors developed an in vivo technique detect using transscleral fine needle aspiration biopsy (FNAB). Methods Eight with medium-sized melanoma were included this prospective study. A 25-gauge FNAB was performed during surgical procedure for brachytherapy, just before applying the radioactive plaque over tumor base. Sampled material underwent...
Most patients affected by chronic lymphocytic leukemia are diagnosed flow cytometry. Several immunophenotypic markers have been identified as significant and independent prognostic variables, especially from retrospective cohorts. However, while attractive because their detection is inexpensive feasible in most laboratories, only few validated series. The expression of leukocyte-associated immunoglobulin-like receptor-1 (also known LAIR1, LAIR-1 or CD305), an inhibitor B-cell...
Recent evidence indicates that protein kinase CK1α may support the growth of multiple myeloma (MM) plasma cells. Here, by analyzing a large cohort MM cases, we found high mRNA levels are virtually associated with all patients. Moreover, provided functional activity is essential for malignant cell survival even in protective niche generated co-cultures bone marrow stromal We demonstrated inactivation, while toxic cells, dispensable healthy B lymphocytes and Disruption function cells resulted...
Aims Bcl2‐positive germinal centres (GCs) have never been documented in reactive lymphoid hyperplasia (RLH). Here we describe such phenomenon paediatric chronic tonsillitis (PCT), addressing the differential diagnosis with lymphomas. Methods and Results Six PCT cases GCs were retrieved from a retrospective series of 166 tonsillectomies children adolescents. Clinical‐pathological data collected, also considering status IG rearrangements BCL2 translocations. mostly occurred males (5/6 cases;...
The effect of antiretroviral therapy on the natural history human papillomavirus (HPV)-associated genital lesions was evaluated in 201 immunodeficiency virus (HIV)-infected women who were followed-up for 1-6 years. Gynecologic examinations performed every 6-12 months. HPV sequences cervico-vaginal cells, analyzed by polymerase chain reaction and typed restriction fragment-length polymorphism analysis, repeatedly detected 126 women; 29 had transient infection. Genital found 137 patients;...
Chronic lymphocytic leukemia (CLL) exhibits substantial variability in disease course. The mutational status of the B-cell receptor immunoglobulin heavy variable (IGHV) chain is a critical prognostic factor, categorizing patients into mutated (M-IGHV) and unmutated (U-IGHV) groups. Recently, third subgroup with borderline (BL-IGHV) has been identified, comprising approximately 5% CLL cases. This study retrospectively analyzes outcomes 30 BL-IGHV among cohort 653 patients, focusing on time to...
Abstract The prognostic and predictive role of specific gene mutations in Waldenström Macroglobulinemia (WM) is well-ascertained whereas the clinical impact chromosome aberrations far less known. Recent work has provided initial evidence for an adverse some aberrations, such as del(6q), while other studies suggest a possible relationship between features ( e.g. advanced age and/or inflammatory status) cytogenetic abnormalities. To add to still limited knowledge on WM cytogenetics its...