A5101845421- Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Dental Implant Techniques and Outcomes
- Silk-based biomaterials and applications
- Craniofacial Disorders and Treatments
- Bone Tissue Engineering Materials
- Cleft Lip and Palate Research
- Cancer Genomics and Diagnostics
- Oral and Maxillofacial Pathology
- Ear and Head Tumors
- Bone health and treatments
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Periodontal Regeneration and Treatments
- Bone Tumor Diagnosis and Treatments
- Orthodontics and Dentofacial Orthopedics
- Autophagy in Disease and Therapy
- Microfluidic and Bio-sensing Technologies
- Cell Adhesion Molecules Research
- Orthopaedic implants and arthroplasty
- Sarcoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Facial Nerve Paralysis Treatment and Research
- Facial Rejuvenation and Surgery Techniques
- Antimicrobial Peptides and Activities
Colorado State University
2025
Wonkwang University
2008-2022
National Cancer Center
2009-2019
Seoul National University
2007-2017
Seoul National University Dental Hospital
2009-2015
International Tuberculosis Research Center
2012
National Medical Research Center of Dentistry and Maxillofacial Surgery
2009
Objectives Bisphosphonates (BP) are widely used in medicine for inhibiting bone resorption; however bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a major side effect BP. To date, there have been no specific reports on incidence BRONJ among Koreans. This study investigated preliminary results from nationwide survey Departments Oral and Maxillofacial Surgery (OMFS) at individual training hospitals. Materials Methods A total 15 OMFS departments (10 dental schools, 4 medical 1...
Pheophorbide a (Pa) is chlorine-based photosensitizer derived from an ethnopharmacological herb, and our group recently synthesized Pa by the removal of magnesium ion phytyl chlorophyll-a. In this study, effect photodynamic therapy (PDT) with was examined in human oral squamous cell carcinoma (OSCC) cells.Cells were treated PDT Pa, reactive oxygen species (ROS) mitochondrial membrane potential [ΔΨ (m)] examined. Apoptosis measured using annexin V staining immunoblot. Autophagy characterized...
Laminin-derived peptide coatings can enhance epithelial cell adhesion to implants, and the positive effect of these peptides on bone has been anticipated. The purpose this study was evaluate improvement in attachment activity titanium (Ti) scaffolds coated with a laminin-derived functional peptide, Ln2-P3 (the DLTIDDSYWYRI motif). Four Ti disc surfaces were prepared, human osteosarcoma (HOS) test performed select two candidate for coating. These candidates then scrambled or left uncoated...
Numerous studies implicate miR-146a as pleiotropic regulator of carcinogenesis; however, its roles in carcinogenesis are not fully understood. A clue from expression analyses miR-146a-5p all 13 oral squamous cell carcinoma (OSCC) lines examined and OSCC tissues, whole blood saliva patients vivo revealed that miR‑146a-5p was highly upregulated. Particularly, we widened the view upregulation saliva, implicating high is only correlated closely to development human cancer, but also a possible...
Abstract Background Ultra-deep sequencing to detect low-frequency mutations in circulating tumor-derived DNA (ctDNA) increases the diagnostic value of liquid biopsy. The demand for large ctDNA panels comprehensive genomic profiling and tumor mutational burden (TMB) estimation is increasing; however, few TMB have been validated. Here, we designed a panel with 531 genes, named TMB500, along technical clinical validation. Methods Synthetic reference cell-free materials predefined allele...
The improved survival of patients with oral cavity cancer (OCC) has generated interest in factors affecting survivorship, particularly among second primary (SPC) patients. This study aimed to assess the incidence, patterns, and risk for SPC after OCC treatment Korean population.Data from 15,261 (ICD-O: C01-C06) identified between 1993 2014 were extracted Central Cancer Registry. standardized incidence ratio (SIR) index was calculated, Poisson regression analysis performed evaluate...
Background: Although hydrogen peroxide may play an important role in the development of cancer, it can be efficient inducer apoptosis cancer cells; exact mechanism by which this action occurs is not completely understood oral cells. Method: In study, mechanisms H 2 O inhibited growth and induced were differentially investigated using HPV‐immortalized human keratinocytes (IHOK) cells (HN4). Results: treatment sensitively dose‐dependently inhibition typical IHOK HN4 cells, as demonstrated a...
Linezolid (Zyvox), an oxazolidinone antibiotic that is widely used for gram-positive infections, increasingly being highly drug-resistant tuberculosis, although it not approved this use by any regulatory body. In case reports and series, linezolid seems to be useful the treatment of both multidrug-resistant (MDR) extensively (XDR) tuberculosis. These have revealed certain side effects are common with long-term linezolid, especially optic peripheral neurologic hematologic toxicities [1]. To...
The DLTIDDSYWYRI motif (Ln2-P3) of human laminin-2 has been reported to promote PC12 cell attachment through syndecan-1; however, the in vivo effects Ln2-P3 have not studied. In Schwann cells differentiated from skin-derived precursors, peptide was effective promoting and spreading vitro. To examine peripheral nerve regeneration vivo, we developed a dual-component poly(p-dioxanone) (PPD)/poly(lactic-co-glycolic acid) (PLGA) artificial graft. novel graft coated with scrambled or used bridge...
Localized acidification of the osteoclast-bone interface is driven by a vacuolar-type H+-ATPase (V-ATPase) in plasma membrane process thought to be associated with bone resorption. The present study investigated mechanism underlying roles V-ATPase-induced acidosis osteoclastogenesis. Active proton pumping due increased V-ATPase activity during RANKL-induced osteoclastogenesis induced intracellular and extracellular osteoclast precursors. Subsequent analysis revealed blockage induction...
Although N(1)-guanyl-1,7,-diamineoheptane (GC7), an inhibitor of deoxyhypusine synthase, has been shown to inhibit cell growth, the mechanism its action is not completely understood. In this study, we investigated mechanisms effects GC7 on differentiation and apoptosis in relation adenosine monophosphate-activated protein kinase (AMPK) activation, as AMPK known be a possible target for cancer treatment.The growth immortalized human oral keratinocytes (IHOK) primary cells (HN4), was using MTT...
Purpose: To compare between a bioactive and bioinert implant with different geometries by continuous measurement of the removal torque calculation angular momentum each surfaced implant. Materials Methods: Six New Zealand white rabbits were used in study. Each rabbit received 2 implants. A fluoride-modified conical connection microthread design was inserted into one tibia, anodically oxidized an external other. After weeks insertion, values continuously measured according to time. Using...
Desmoplastic melanoma of the oral cavity is an extremely rare condition that often confused on initial diagnosis with non-melanotic benign lesion or spindle cell tumors. The purpose this article was to raise awareness disease using a literature review.We analyzed 19 desmoplastic cases reported in and added our experience. Data clinical, histopathology, treatment, survival were retrieved analyzed. Survival analysis by Kaplan-Meier method.Initial clinical histopathological features...
Functional peptides are attractive as novel therapeutic reagents because their amino acid sequences flexible in adopting and mimicking the local functional features of proteins. These low molecular weight, synthetically versatile inexpensive to produce, suggesting that they can be used drug targeting, potent, stable bioavailable agents. A short bioactive peptide is expected more beneficial regenerative medicine than an entire protein lower antigenicity sequences. We detected core from human...
Cross-facial nerve graft is considered the treatment of choice for facial reanimation in patients with unilateral palsy caused by central damage. In most cases, a traditional parotidectomy skin incision used to locate buccal and zygomatic branches nerve.In this study, cross-facial sural was planned three through an intraoral approach.An made on cheek mucosa, dissection performed branch nerve. The parotid papillae duct were as anatomic landmarks branch.The approach more advantageous than...
To assess the association between muscle invasion by oral squamous cell carcinoma of posterior mandibular alveolar ridge and cervical lymph node metastasis on basis preoperative magnetic resonance imaging (MRI).Twenty-six patients with were evaluated MRI. The associations independent factors MRI analyzed. Overall survival was also analyzed in this manner. Representative biopsy specimens stained anti-podoplanin anti-CD34 antibodies.Mylohyoid associated metastasis. A combinational factor...