A5067356645- Oral and Maxillofacial Pathology
- Bone Tumor Diagnosis and Treatments
- Tumors and Oncological Cases
- Sarcoma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Peptidase Inhibition and Analysis
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cancer Diagnosis and Treatment
- Cell death mechanisms and regulation
- Angiogenesis and VEGF in Cancer
- Cell Adhesion Molecules Research
- Cancer-related gene regulation
- Soft tissue tumor case studies
- Hedgehog Signaling Pathway Studies
- Ear and Head Tumors
- interferon and immune responses
- dental development and anomalies
- PI3K/AKT/mTOR signaling in cancer
- Infectious Diseases and Mycology
- Cancer Immunotherapy and Biomarkers
- Histiocytic Disorders and Treatments
- Musculoskeletal synovial abnormalities and treatments
- Head and Neck Surgical Oncology
- Hippo pathway signaling and YAP/TAZ
Seoul National University
2015-2024
Seoul National University Dental Hospital
2015-2024
Georgia Institute of Technology
2020
Gyeongsang National University
2020
National University College
2020
New Generation University College
2020
Center for Rheumatology
2006
Namseoul University
2006
The Akt/PKB family of kinases is frequently activated in human cancers, including oral squamous cell carcinoma (OSCC). Akt-induced epithelial-to-mesenchymal transition (EMT) involves downregulation E-cadherin, which appears to result from upregulation the transcription repressor Snail. Recently, it was proposed that cells, especially metastatic sites, could acquire mesenchymal-to-epithelial reverting (MErT) order adapt microenvironments and re-expression E-cadherin be a critical indicator...
Eugenol is widely used in dentistry as a local analgesic agent, because of its ability to allay tooth pain. Interestingly, eugenol shares several pharmacological actions with anesthetics which include inhibition voltage-gated sodium channel (VGSC) and activation transient receptor potential vanilloid subtype 1 (TRPV1). In the present study, we investigated effects on pain behaviors orofacial area, an attempt elucidate mechanism characterized inhibitory VGSCs trigeminal ganglion (TG) neurons....
Silymarin, a standardized extract from milk thistle fruits has been found to exhibit anti-cancer effects against various cancers. Here, we explored the activity of silymarin and its molecular target in human oral cancer vitro vivo. Silymarin dose-dependently inhibited proliferation HSC-4 cells promoted caspase-dependent apoptosis. A apoptosis protein array kit showed that death receptor 5 may be involved silymarin-induced apoptosis, which was also shown through western blotting,...
BRAF V600E mutations are activating that have recently been detected in ameloblastoma. However, their prevalence has not reported East Asian patients with ameloblastoma and clinicopathological significance remains unclear. In this study, we examined the of Korean addition, investigated relationship between epithelial-mesenchymal transition, which studied ameloblastoma.Thirty tissue samples were collected, DNA isolation, polymerase chain reaction, Sanger sequencing performed to detect...
Nitidine chloride (NC) is a natural alkaloid compound derived from the plant Zanthoxylum nitidum and known for its therapeutic anticancer potential. In this study, we investigated effects of NC on growth signaling pathways in human oral cancer cell lines tumor xenograft model. The apoptotic related molecular targets were using trypan blue exclusion assay, DAPI staining, Live/Dead Western blotting, Immunohistochemistry/Immunofluorescence nude mouse xenograft. decreased viability both HSC3...
Abstract The rhizome of Zingiber officinale ( Z. ), commonly known as ginger, has been characterized a potential drug candidate due to its antitumor effects. However, the chemotherapeutic effect ginger on human oral cancer remains poorly understood. In this study, we examined effects an ethanol extract rhizomes (ZOE) and identified components responsible for pharmacological activity. ZOE exerts inhibitory activity in by inducing both autophagy apoptosis simultaneously. Mechanistically,...
Embryonic stem cells (ESCs) are pluripotent and can differentiate into all somatic cell types. ESCs an alternative solution to hard tissue regeneration skeletal repair treat bone diseases defects using regenerative strategies. Parthenogenetic (PESCs) may be a useful source for regeneration. The in full-term development of this type enable researchers avoid the ethical concerns related ESC research. Moreover, female patients, if PESCs derived from oocytes, then they will have that patient's...