A5000570696- Asymmetric Synthesis and Catalysis
- Chemical synthesis and alkaloids
- Botanical Research and Chemistry
- Organic Chemistry Cycloaddition Reactions
- Phytochemical compounds biological activities
- Steroid Chemistry and Biochemistry
- Synthetic Organic Chemistry Methods
- Cancer Treatment and Pharmacology
- Plant-based Medicinal Research
- Molecular spectroscopy and chirality
- Statistical Methods and Inference
- Analytical Chemistry and Chromatography
- Inorganic and Organometallic Chemistry
- Alkaloids: synthesis and pharmacology
- Adipokines, Inflammation, and Metabolic Diseases
- Oxidative Organic Chemistry Reactions
- Chemical Synthesis and Analysis
- Carbohydrate Chemistry and Synthesis
- Cholinesterase and Neurodegenerative Diseases
- Advanced Synthetic Organic Chemistry
- Nutritional Studies and Diet
- Fluorine in Organic Chemistry
- Education, Psychology, and Social Research
- Cardiac Imaging and Diagnostics
- Natural product bioactivities and synthesis
Czech Academy of Sciences, Institute of Computer Science
2015-2024
Czech Academy of Sciences
2015-2024
Charles University
2011
Institute for Atherosclerosis Research
2009
Krajská Zdravotní
2009
University of Pardubice
2007
EuroMISE (Czechia)
2006
Institute of Clinical and Experimental Medicine
1993-2006
University of Pittsburgh
2002-2004
University of New Brunswick
1980-2003
Our goal was to describe disease-specific survival and the clinical variables that predict in a large national cohort of adult liver transplant recipients. Data on 17,044 patients who received an initial orthotopic between 1990 1996 with follow-up through 1999 obtained from United Network for Organ Sharing (UNOS). Disease-specific Kaplan-Meier plots Cox Proportional Hazards models were estimated, differences characteristics at time transplantation by disease examined. Overall posttransplant...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE TOTAL SYNTHESIS OF CHLOROPHYLLR. B. Woodward, W. A. Ayer, J. M. Beaton, F. Bickelhaupt, R. Bonnett, P. Buchschacher, G. L. Closs, H. Dutler, Hannah, Hauck, S. Itô, Langemann, E. Le Goff, Leimgruber, Lwowski, Sauer, Z. Valenta, and VolzCite this: Am. Chem. Soc. 1960, 82, 14, 3800–3802Publication Date (Print):July 1, 1960Publication History Published online1 May 2002Published inissue 1 July...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Dimethylapoerysopine and an Approach to the Total Synthesis Unrearranged Erythrina BasesK. Wiesner, Z. Valenta, A. J. Manson, F. W. StonnerCite this: Am. Chem. Soc. 1955, 77, 3, 675–683Publication Date (Print):February 1, 1955Publication History Published online1 May 2002Published inissue 1 February 1955https://doi.org/10.1021/ja01608a040RIGHTS & PERMISSIONSArticle Views397Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are...
Selagine, an alkaloid of Lycopodiumselago, is shown to be identical with huperzine A (2). minor alkaloid, C 15 H 18 N 2 O , isolated from L. selago found 6β-hydroxyhuperzine (4). Keywords: A, selagine, Lycopodium alkaloids, Alzheimer's disease, acetylcholine esterase inhibitor.
A total synthesis of ring aromatic D-homosteroids and the conversion one them to estrone its derivatives are described. The key reaction is a catalysed addition 6-methoxy-1-vinyl-3,4-dihydronaphthalene 2,6-dimethyl-1,4-quinone which proceeds with orientation inversion compared thermal addition. Reactions several other quinones synthetic sequence includes hydride reduction in an apparently more hindered carbonyl group enedione system reduced preferentially. Cyclization 1,6-keto aldehyde under...
Cardiovascular disease, while rare in women of reproductive age, is the main cause mortality menopause. The purpose our study was to determine association natural menopause with cardiovascular risk factors, including their clustering into metabolic syndrome (MS). A random 5 % representative population sample aged 45-54 years examined. In 575 women, we were able aging status. Multiple regression analysis used calculate between menopausal status, and factors under study. After adjustment for...
Pithecolobine, C 22 H 46 N 4 O 2 , has a lactam group, one primary and two secondary amino groups, hydroxyl group. Lithium aluminum hydride converts it into monocyclic saturated compound, desoxypithecolobine, 48 . Hofmann degradation of this compound gives tetramethylputrescine, trimethyl amine, doubly unsaturated base 16 31 with terminal methylene 34 Heating selenium yields hydrocarbon, 12 ;H 24–26 sequence six or more CH groups. A crystalline oxygen-free nitrogens (m.p.94 °C.) is also...
The advent of new, advanced quantitative MRI metrics allows for in vivo evaluation multiple biological processes highly relevant ageing. presented study combines several parameters hypothesised to detect distinct characteristics as myelin density, cellularity, cellular membrane integrity and iron concentration. 116 healthy volunteers, continuously distributed over the whole adult age span, underwent a multi-modal protocol acquisition. Scatterplots individual revealed that certain protocols...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModeling of steric control facial stereoselectivity. Diels-Alder cycloadditions unsymmetrically substituted cyclopentadienesFrank K. Brown, N. Houk, D. Jean Burnell, and Z. ValentaCite this: J. Org. Chem. 1987, 52, 14, 3050–3059Publication Date (Print):July 1, 1987Publication History Published online1 May 2002Published inissue 1 July 1987https://pubs.acs.org/doi/10.1021/jo00390a017https://doi.org/10.1021/jo00390a017research-articleACS...
Lewis acid catalysts cause an orientation reversal in the Diels–Alder additions of 2,6-di-methyl-1,4-quinone (1) and toluquinone (12) to 1-substituted 1,3-butadienes 1,2- 1,3-dialkyl dienes. These results are explained by preferential formation one reactive quinone–Lewis salt.
A diene synthesis using 2,6-xyloquinone as dienophile and boron trifluoride catalyst does not follow the normal orientation rules leads to a facile of ring A-aromatic steroids. tetracyclic adduct prepared by similar reaction containing steroidal C 19 -methyl group is also reported.
Kriz P, Seydlova M, Dostalova T, Valenta Z, Chleborad K, Zvarova J, Feberova Hippmann R. Dental implants and improvement of oral health‐related quality life. Community Dent Oral Epidemiol 2012; 40 (Suppl. 1): 65–70. © 2012 John Wiley & Sons A/S Abstract – Objectives: life (OHRQoL) is a multifaceted field involving many factors. The aim our study was to assess whether implant therapy improves OHRQoL in dental patients. Methods: Patients receiving at least one completed questionnaire...
Background The purpose of this study was to show our comparison the quality voice obtained after superficial transoral endoscopic cordectomies (types I, II, and III) according European Laryngological Society classification versus more extended cordectomy IV V) among patients with glottic precancerous lesions or early cancer. Methods Sixty-two underwent vocal assessment I–V) for dysplasia, Tis, T1a, T1b, T2 lesions. Results Cordectomy I–III) had good outcomes. IV–V) showed less favorable...