A5037583866- Spectroscopy Techniques in Biomedical and Chemical Research
- Gold and Silver Nanoparticles Synthesis and Applications
- Spectroscopy and Chemometric Analyses
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Protein Interaction Studies and Fluorescence Analysis
- Biosensors and Analytical Detection
- Identification and Quantification in Food
- Nanoplatforms for cancer theranostics
- Photoacoustic and Ultrasonic Imaging
- Laser-induced spectroscopy and plasma
- Nanocluster Synthesis and Applications
- RNA Interference and Gene Delivery
- Optical Imaging and Spectroscopy Techniques
Dana-Farber Cancer Institute
2020-2024
Harvard University
2020-2024
Memorial Sloan Kettering Cancer Center
2019-2020
University of Strathclyde
2017-2018
Rationale:The goal of imaging tumors at depth with high sensitivity and specificity represents a significant challenge in the field biomedical optical imaging.'Surface enhanced Raman scattering' (SERS) nanoparticles (NPs) have been employed as image contrast agents can be used to specifically target cells vivo.By tracking their unique "fingerprint" spectra, it becomes possible determine precise location.However, while detection SERS NPs is very sensitive specific, conventional spectroscopy...
Detection of a live 3D tumour model through 15 mm tissue using SESORRS.
Through utilizing the depth penetration capabilities of SESORS, multiplexed imaging and classification three singleplex nanotags a triplex within breast cancer tumour models is reported for first time through depths 10 mm using handheld SORS instrument.
In the field of optical imaging, ability to image tumors at depth with high selectivity and specificity remains a challenge. Surface enhanced resonance Raman scattering (SERRS) nanoparticles (NPs) can be employed as contrast agents specifically target cells in vivo; however, this technique typically requires time-intensive point-by-point acquisition spectra. Here, we combine use "spatially offset spectroscopy" (SORS) that SERRS known "surface spatially (SESORRS) deep-seated vivo....
The ability to probe through barriers and tissue non-invasively is an urgent unmet need in both the security biomedical imaging fields. Surface enhanced Raman spectroscopy (SERS) has been shown yield superior enhancement signal over conventional techniques. Furthermore, by utilising a resonant reporter produce surface resonance (SERRS), even greater chemical can be generated. Here we show benefit of using red-shifted chalcogenpyrylium based reporters for probing large thicknesses plastic...
Jürgen Popp opened a general discussion of the paper by Roy Goodacre: What is advantage using SERS instead ordinary Raman spectroscopy? Goodacre replied: and in context stable isotopically labeled substrates to investigate metabolism within t
Abstract Spatially offset Raman spectroscopy (SORS) provides chemical analysis at depth even when obscuring barriers such as plastic or tissue are present. As the collection probe is moved further away from point of laser excitation, scattered photons deeper layers begin to dominate acquired spectra, thus giving rise through barrier detection. Here, we demonstrate potential conventional (CR) and SORS for detection using handheld spectrometers. We report signals an ethanol solution...
Ovarian cancer represents the deadliest gynecologic malignancy. Most patients present at an advanced stage (FIGO III or IV), when local metastatic spread has already occurred. However, ovarian a unique pattern of spread, in that tumor implants are initially contained within peritoneal cavity. This feature could enable, principle, complete resection with curative intent. Many these lesions microscopic, making them hard to identify and treat. Neutralizing such micrometastases is believed be...
Resonant chalcogenpyrylium nanotags demonstrate an exceptional surface enhanced Raman scattering (SERS) performance for use in SORS applications. Using spatially offset spectroscopy (SESORS), modified with a dye were observed at concentrations as low 1 pM through 5 mm of tissue. Calculated limits detection suggest that these SERS can be detected 104 fM using resonance (SESORRS) demonstrating their potential vivo
Ovarian cancer represents the deadliest gynecologic malignancy. Most patients present at an advanced stage (FIGO III or IV), when local metastatic spread has already occurred. However, ovarian a unique pattern of spread, in that tumor implants are initially contained within peritoneal cavity. This feature could enable, principle, complete resection with curative intent. Many these lesions microscopic, making them hard to identify and treat. Neutralizing such micrometastases is believed be...
Abstract Background and Rationale In the field of optical imaging, ability to image tumors at depth with high selectivity specificity remains a challenge. Surface enhanced resonance Raman scattering (SERRS) nanoparticles (NPs) can be employed as contrast agents specifically target cells in vivo , however, this technique typically requires time-intensive point-by-point acquisition spectra, thus hindering real-time desired for clinical applications. Moreover, traditional approaches involving...