A5052146579- Child and Adolescent Psychosocial and Emotional Development
- Child Abuse and Trauma
- Personality Disorders and Psychopathology
- Mental Health Research Topics
- Psychological Well-being and Life Satisfaction
- Child and Adolescent Health
- Health, Environment, Cognitive Aging
- Maternal Mental Health During Pregnancy and Postpartum
- Migration, Health and Trauma
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health disparities and outcomes
- Bullying, Victimization, and Aggression
- Resilience and Mental Health
- Autism Spectrum Disorder Research
- Adolescent and Pediatric Healthcare
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Schizophrenia research and treatment
- Intimate Partner and Family Violence
- Psychological Testing and Assessment
- Mindfulness and Compassion Interventions
- Pharmacogenetics and Drug Metabolism
- Peroxisome Proliferator-Activated Receptors
- Neural and Behavioral Psychology Studies
- Psychosomatic Disorders and Their Treatments
- Attention Deficit Hyperactivity Disorder
King's College London
2016-2024
Yale University
2021
Czech Academy of Sciences, Institute of Psychology
2016
MJ Medical (United Kingdom)
2016
Merck & Co., Inc., Rahway, NJ, USA (United States)
2009
Adverse childhood experiences (ACEs) are well-established risk factors for health problems in a population. However, it is not known whether screening ACEs can accurately identify individuals who develop later problems.To test the predictive accuracy of ACE problems.This study comprised 2 birth cohorts: Environmental Risk (E-Risk) Longitudinal Twin Study observed 2232 participants born during period from 1994 to 1995 until they were aged 18 years (2012-2014); Dunedin Multidisciplinary Health...
Background: Loneliness co-occurs alongside many mental health problems and is associated with poorer treatment outcomes. It could therefore be a phenomenon of interest to clinicians as an indicator generalised risk for psychopathology. The present study tested whether short measure loneliness can accurately classify individuals who are at increased common problems. Methods: Data were drawn from two nationally representative cohorts: the age-18 wave UK-based Environmental Risk (E-Risk)...
Adverse childhood experiences confer an increased risk for physical and mental health problems across the population, prompting calls routine clinical screening based on reported adverse experience exposure. However, recent longitudinal research has questioned whether can accurately identify ill at individual level.Revisiting data collected Childhood Experience Study between 1995 1997, this study derived approximate area under curve estimates to test ability of retrospectively score...
Victimized children are at greater risk for psychopathology than non-victimized peers. However, not all victimized develop psychiatric disorders, and accurately identifying which greatest is important to provide targeted interventions. This study sought internally validate individualized prediction models among children.Participants were members of the Environmental Risk (E-Risk) Longitudinal Twin Study, a nationally-representative British birth cohort 2,232 twins born in 1994-1995....
Growing evidence suggests heterogeneity within interpersonal-callous (IC) youth based on co-occurring anxiety. The developmental validity of this proposed taxonomy remains unclear however, as most previous research is cross-sectional and/or limited to adolescence. We aimed identify low-anxiety (IC/ANX-) and high-anxiety (IC/ANX+) IC variants, compare these groups (a) early risk exposures, (b) psychiatric symptoms from midchildhood adolescence, (c) school-based functioning. Using the Avon...
Early difficult temperament and child mental health problems are consistently associated with impaired functioning in adulthood. We examined three potential pathways between toddlerhood (age 2) depressive symptoms (ages 21–23) well-being 23): i) direct – early directly associates these outcomes, ii) mediated effects also by a general psychopathology factor late childhood/early adolescence (GPF; ages 7, 10,and 13), iii) moderated-mediated moderated negative 42 months) positive 33 parenting...
In 671 mother–child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7–13) of oppositional defiant disorder (ODD), the ODD subdimensions irritable headstrong; (b) common biological pathways, indexed by methylation, attention deficit hyperactivity (ADHD); (c) genetic influence on methylation; (d) prenatal risk exposure associations. Methylome‐wide significant were identified for...
Abstract The tendency to select threatening over benign interpretations of ambiguous bodily sensations and cues characterises young people with chronic pain. However, previous studies disagree whether these biases extend nonbodily harm situations such as social evaluation. Understanding the content is crucial development pain management strategies seeking modify biases. Two hundred forty-three aged 16 19 years completed an expanded version Adolescent Interpretation Bodily Threat task. Using...
Previous factor-analytic studies identify significant comorbidity between interpersonal-callous (IC) traits and low prosocial behavior (LPB), which, in turn, is associated with high levels of childhood risk exposure psychopathology. Longitudinal associations IC, LPB, or their combination, early-adult health social functioning have not been investigated, however. Extending a previously-identified bifactor model within prospective birth cohort, this study applied latent path analysis to test...
Childhood victimization elevates the average risk of developing functional impairment in adulthood. However, not all victimized children demonstrate poor outcomes. Although research has described factors that confer vulnerability or resilience, it is unknown if this knowledge can be translated to accurately identify most vulnerable children.To build and internally validate a calculator those who are at age 18 years.We utilized data from Environmental Risk (E-Risk) Longitudinal Twin Study,...
Difficulties with prospective mental images are associated adolescent depression. Current treatments mainly focus on verbal techniques to reduce negative affect (e.g. low mood) rather than enhancing positive affect, despite anhedonia being present in adolescents. We investigated the concurrent relationships between vividness of and imagery affect; examined whether moderated impact recent stress (COVID-19-linked stress) affect.2602 young people (12-25 years) completed Prospective Imagery Task...
Although low prosocial behavior (LPB) items have been incorporated into youth measures of callousness, it remains unclear from current factor analytic findings whether callous traits and LPB are best operationalized as a common construct, or distinct dimensions. Using data population-representative birth cohort (N = 5,463), this study compared 4 latent structures for interpersonal callousness (IC; 6 items) (5 at age 13: (a) unidimensional; (b) two-factor; (c) higher-order (with 2...
Laropiprant (LRPT), a prostaglandin D 2 receptor‐1 antagonist shown to reduce niacin‐induced flushing symptoms, has been combined with niacin for treatment of dyslipidemia. This open‐label, randomized, 2‐period crossover study assessed the pharmacokinetics single‐dose rosiglitazone in presence and absence multiple‐dose LRPT. Twelve healthy male female subjects, 34–64 years age, received two, once‐daily oral treatments random sequence separated by ≥3‐day washout: (1) LRPT 40 mg/day 7 days...
As internet access and use increase exponentially, pedagogical practice becomes increasingly embedded in online platforms. We report on an initiative of engaged student learning, the peer-led, staff-assisted e-helpdesk for research methods statistics, which we evaluated redeveloped using lens guiding principles framework partnership learning teaching Higher Education Academy (HEA). The aim redevelopment was to steer towards a more integrative sustainable implementation, as manifest applied...
Abstract Adolescent depression is associated with unhelpful emotional mental imagery. Here, we investigated whether vividness of negative and positive prospective imagery predict affect anhedonia in adolescents. 111 people from Israel completed measures imagery, affect, at two time-points approximately three months apart. Using cross-lagged panel models, showed once ‘concurrent’ (across-variable, within-time) ‘stability’ paths (across-time, within-variable) were estimated, there no...
Background: Empirical observations consistently demonstrate heightened levels of trauma and bullying victimization among children adolescents with conduct problems. However, most this evidence is generated in high-income countries little known about the development problems low- middle-income countries, which are characterized by elevated risks threat deprivation. Methods: To explore a high-risk setting, we used data from 2,511 young people (aged 6 - 23 years) enrolled Brazilian High Risk...