A5031062370- Schizophrenia research and treatment
- Epigenetics and DNA Methylation
- Treatment of Major Depression
- Tryptophan and brain disorders
- Family Caregiving in Mental Illness
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Stress Responses and Cortisol
- Cardiac Health and Mental Health
- Advanced Neuroimaging Techniques and Applications
- Electroconvulsive Therapy Studies
- Mental Health Research Topics
- Bipolar Disorder and Treatment
- LGBTQ Health, Identity, and Policy
- Migration, Health and Trauma
- Immunodeficiency and Autoimmune Disorders
- Neuroscience and Neuropharmacology Research
- COVID-19 and Mental Health
- Mental Health and Psychiatry
- Posttraumatic Stress Disorder Research
- Diet and metabolism studies
- Genetic Associations and Epidemiology
- Cholinesterase and Neurodegenerative Diseases
- Outsourcing and Supply Chain Management
- Diabetes and associated disorders
Warneford Hospital
2020-2025
University of Oxford
2018-2025
Oxford Health NHS Foundation Trust
2020-2025
King's College London
2017-2024
University of Nottingham
2019
<h3>Importance</h3> This is the first comprehensive national study reporting rates of abuse, neglect, and bullying from family classmates or teachers among Chinese transgender gender-nonbinary adolescents identifying risk factors associated with poor mental health in this population. <h3>Objective</h3> To assess their association gender nonbinary adolescents. <h3>Design, Setting, Participants</h3> survey used an online self-selecting conducted between January 1, 2017, September 29, China....
It has been suggested that the antipsychotic clozapine may modulate brain glutamate, and this effect could contribute to its efficacy in treatment-resistant schizophrenia (TRS). The aim of study was examine effects on glutamate TRS longitudinally. This examined individuals with before 12 weeks after switching from a non-clozapine treatment as part their normal clinical care. Proton magnetic resonance spectroscopy (1H-MRS) measured concentrations, corrected for voxel tissue content,...
Abstract Background Depression is common and costly. First-line antidepressants are ineffective for many have little impact against cognitive deficits. Stimulating 5-HT4 receptors (5-HT4R) rapidly improves learning has antidepressant-like effects in rodents 1,2. The highly-selective 5-HT4R agonist, prucalopride (licensed constipation), had a facilitatory effect on behavioural learning/memory healthy humans after single 3 6 days' treatment 4,5. Neurally, it also increased hippocampal activity...
Abstract Background Statins are among the most prescribed medications worldwide. Both beneficial (e.g. antidepressant and pro-cognitive) adverse depressogenic cognitive-impairing) mental health outcomes have been described in clinical studies. The underlying neuropsychological mechanisms, whether positive or negative, are, however, not established. Clarifying such activities has implications for safe prescribing repurposing potential of these drugs, especially people with depression. Methods...
Abstract The neurobiological effects of clozapine are under characterised. We examined the treatment on subcortical volume and cortical thickness investigated whether macrostructural changes were linked to alterations in glutamate or N-acetylaspartate (NAA). Data acquired 24 patients with treatment-resistant schizophrenia before 12 weeks after switching clozapine. During we observed reductions caudate putamen volume, lateral ventricle enlargement ( P < 0.001), left inferior temporal...
The post-disaster mental health crisis intervention (MHCI) system in China remains immature and unsystematic. We aim to report the perceptions of a large sample MHCI workers government administrators provide recommendations for developing national disaster response management plan China. An in-depth qualitative study was conducted, collecting data from 20 focus-group discussions 25 key stakeholder interviews. These recruited participants who had been involved different types rescue across 7...
Abstract Background This study aimed to examine the efficacy of combining paroxetine and mirtazapine v. switching mirtazapine, for patients with major depressive disorder (MDD) who have had an insufficient response SSRI monotherapy (paroxetine) after first 2 weeks treatment. Methods double-blind, randomized, placebo-controlled, three-arm recruited participants from five hospitals in China. Eligible were aged 18–60 years MDD at least moderate severity. Participants received during a 2-week...
<h2>Abstract</h2><h3>Background</h3> There is growing interest in the antidepressant potential of statins. We tested whether statin use associated with cognitive markers previously found to indicate psychological vulnerability depression within context COVID-19 pandemic. <h3>Methods</h3> Between April 2020 and February 2021, we conducted an observational online study 2043 adults United Kingdom. Participants completed tasks assessing processes related vulnerability, including affective bias...
Abstract Background The COVID-19 pandemic highlighted the need for mental health interventions that can be easily disseminated during a crisis. Behavioural activation (BA) is cost-effective treatment administered by non-specialists; however, it unclear whether still effective time of lockdown and social distancing, when opportunities positive activity are significantly constrained. Methods Between May October 2020, we randomised 68 UK participants with mild to moderate low mood either 4-week...
As internet access and use increase exponentially, pedagogical practice becomes increasingly embedded in online platforms. We report on an initiative of engaged student learning, the peer-led, staff-assisted e-helpdesk for research methods statistics, which we evaluated redeveloped using lens guiding principles framework partnership learning teaching Higher Education Academy (HEA). The aim redevelopment was to steer towards a more integrative sustainable implementation, as manifest applied...
<title>Abstract</title> Neuroimaging studies indicate that in treatment resistant schizophrenia (TRS), alterations regional cerebral blood flow (CBF) during clozapine may vary according to the clinical response. To date, these have involved radiotracers. Here, we used arterial spin labelling (ASL) compare CBF participants with TRS (N=36) before starting and healthy volunteers (N=16). We then compared after 12 weeks of (N=24), relation changes Positive Negative Syndrome Scale for...