A5028122209- Congenital Diaphragmatic Hernia Studies
- Neonatal Respiratory Health Research
- Congenital Anomalies and Fetal Surgery
- Tracheal and airway disorders
- Clinical Nutrition and Gastroenterology
- Infant Nutrition and Health
- Wound Healing and Treatments
- Congenital Heart Disease Studies
- Esophageal and GI Pathology
- Diversity and Career in Medicine
- Health and Medical Research Impacts
- Teratomas and Epidermoid Cysts
- Spinal Dysraphism and Malformations
- Cardiac, Anesthesia and Surgical Outcomes
- Mechanical Circulatory Support Devices
- Pediatric Hepatobiliary Diseases and Treatments
- Tumors and Oncological Cases
- Innovations in Medical Education
- Pregnancy and preeclampsia studies
- Intestinal Malrotation and Obstruction Disorders
- Congenital heart defects research
- Viral gastroenteritis research and epidemiology
- Fetal and Pediatric Neurological Disorders
- Prenatal Screening and Diagnostics
- Hair Growth and Disorders
Baylor College of Medicine
2016-2025
Texas Children's Hospital
2014-2024
Emory University
2023
Boston Children's Hospital
2014-2022
Massachusetts General Hospital
2022
Twitter (United States)
2022
Nationwide Children's Hospital
2020
United States Department of Agriculture
2015
Baylor University
2015
In-Q-Tel
2012
To determine associations between fetal lung and liver herniation volumes measured by magnetic resonance imaging (MRI) mortality/need for extracorporeal membrane oxygenation (ECMO) in cases of isolated congenital diaphragmatic hernia (CDH). A secondary objective was to compare prenatal MRI parameters with two-dimensional ultrasound measurements.A retrospective review medical records all fetuses CDH evaluated January 2004 July 2012 performed. The following were at 20-32 weeks:...
Abstract Endothelial progenitor cells (EPCs) contribute to de novo angiogenesis, tissue regeneration, and remodeling. Interleukin 10 (IL‐10), an anti‐inflammatory cytokine that primarily signals via STAT3, has been shown drive EPC recruitment injured tissues. Our previous work demonstrated overexpression of IL‐10 in dermal wounds promotes regenerative repair STAT3‐dependent regulation fibroblast‐specific hyaluronan synthesis. However, IL‐10's role specific mode action on recruitment,...
Necrotizing enterocolitis (NEC) remains the most severe gastrointestinal disorder in preterm infants. It is associated with initiation of enteral nutrition and may be related to immature carbohydrate digestive capacity. We tested hypothesis that a formula containing maltodextrin vs. lactose as principal source would predispose pigs higher NEC incidence. Cesarean-derived were given total parenteral for 48 h followed by lactose-based ( n = 11) or maltodextrin-based 36 h. A incidence (91% 27%)...
Thromboelastography (TEG) aids in monitoring a patient's global hemostatic system by measuring the rate of clot formation, strength, and stability. The usefulness TEG pediatric settings, especially with neonates, is limited owing to lack neonatal reference values. In this study, intervals were developed results correlated other coagulation test parameters. Samples from women who delivered neonate after at least 34 weeks gestation normal pregnancies. From recovered placenta, cord blood...
To compare the referral diagnosis based on prenatal ultrasound to diagnoses made following combined (US) and magnetic resonance imaging (MRI) evaluation at Texas Children's Fetal Center (TCFC) postnatal diagnosis.We performed a retrospective review of patients referred TCFC between September 2001 July 2007 with fetal structural malformation. Data were abstracted both compared diagnosis.Two hundred twenty-four who had US MRI TCFC. The most frequent indications for abnormalities central...
Fetal endoscopic tracheal occlusion (FETO) is associated with increased perinatal survival and reduced need for extracorporeal membrane oxygenation (ECMO) in fetuses severe congenital diaphragmatic hernia (CDH). This study evaluates the impact of FETO on resolution pulmonary hypertension (PH) isolated CDH.We reviewed retrospectively medical records all evaluated CDH between January 2004 July 2017 at a single institution. Fetuses additional major structural or chromosomal abnormalities were...
To compare histopathologic features of a fibroproliferative disorder in horses (exuberant granulation tissue-EGT) and people (keloid).Archival tissue samples EGT (n = 8) keloid (12).After automated hematoxylin eosin, histochemical (Gomori trichrome, Verhoeff-van Gieson elastin) immunohistochemical (vimentin, α-smooth muscle actin, CD34, CD68, CD117) stainings, sections were evaluated using semi-quantitative grading scale for presence or absence ulceration, keloidal collagen, myofibroblasts,...
ABSTRACT Negative pressure therapy (NPT) has been accepted as a valuable adjunct for wound closure in adults; however, reports on its effectiveness young children and infants, including neonates, are limited. A retrospective chart review was conducted treated with NPT at single institution between January 2003 December 2005. Wound volumetric measurements were calculated the start end of therapy. Sixty‐eight patients 82 wounds identified. The mean age 8.5 years (range 7 days–18 years). Twenty...
FETAL anomalies such as giant neck masses can result in perinatal death or hypoxia and anoxic brain injury due to inability secure an airway a timely fashion after delivery. Modern technology, ultrasound, ultrafast magnetic resonance imaging have enabled intrauterine diagnosis fetal interventions mode of therapy, thereby giving affected fetuses chance at survival.Initially, the Ex Utero Intrapartum Therapy (EXIT) procedure was exclusively performed large tertiary children's hospitals because...
To identify early markers of necrotizing enterocolitis (NEC), we hypothesized that continuous abdominal near-infrared spectroscopy (A-NIRS) measurement splanchnic tissue oxygen saturation and intermittent plasma intestinal fatty-acid binding protein (pI-FABP) measured every 6 hours can detect NEC prior to onset clinical symptoms. Premature piglets received parenteral nutrition for 48-hours after delivery, followed by enteral feeds three until death or euthanasia at 96-hours. Continuous...
Major risk factors for necrotizing enterocolitis (NEC) include premature birth and formula feeding in the context of microbial colonization gastrointestinal tract. We previously showed that composed lactose vs. corn syrup solids protects against NEC preterm pigs; however, metabolic effects these different carbohydrates used infant has not been explored. Our objective was to characterize lactose- solid-based formulas on profiles piglets determine whether unique metabolomic or microbiome...