A5100644153- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Piperaceae Chemical and Biological Studies
- Phytochemicals and Antioxidant Activities
- Traditional and Medicinal Uses of Annonaceae
- Cholinesterase and Neurodegenerative Diseases
- Genomics, phytochemicals, and oxidative stress
- Traditional Chinese Medicine Analysis
- Plant-Derived Bioactive Compounds
- Bioactive Compounds and Antitumor Agents
- Essential Oils and Antimicrobial Activity
- Medicinal Plants and Neuroprotection
- Plant-derived Lignans Synthesis and Bioactivity
- Natural Antidiabetic Agents Studies
- Phytochemical compounds biological activities
- Ginger and Zingiberaceae research
- Protein Tyrosine Phosphatases
- Carbohydrate Chemistry and Synthesis
- Bone Metabolism and Diseases
- Biological Stains and Phytochemicals
- Ginseng Biological Effects and Applications
- Medicinal plant effects and applications
- melanin and skin pigmentation
- Pharmacogenetics and Drug Metabolism
Kyungpook National University
2016-2025
National University College
2024
Korea Research Institute of Bioscience and Biotechnology
2011-2021
Gyeongsang National University
2018-2020
Osong Medical Innovation Foundation
2018
Korea University
2018
Agency for Defense Development
2018
United States Army Medical Research Institute of Infectious Diseases
2018
National Health Insurance Service
2017
National Health Insurance Service Ilsan Hospital
2017
Glycyrrhizin is the major active component extracted from licorice (Glycyrrhiza glabra) roots, one of most widely used herbal preparations for treatment liver disorders. This study evaluated potential beneficial effect glycyrrhizin in a mouse model carbon tetrachloride (CCl4)-induced injury. The mice were treated intraperitoneally with CCl4 (0.5 ml/kg). They received (50, 100, 200, 400 mg/kg) 24 h and 0.5 before 4 after administering CCl4. serum activities aminotransferase hepatic level...
The onion, known as the bulb onion or common is not only a key ingredient in many tasty and healthy vegetarian meals but also traditional medicines. Nine new flavonoids [cepaflavas A, B (5, 6), cepadials A–D (7–9 14), cepabiflas A–C (10–12)] six compounds (1–4, 13, 15) were obtained from outer skins of Allium cepa L. Among them, 5, 6, 9 might be artificial products formed during extraction isolation. New structurally elucidated using various spectroscopy/spectrometry techniques, including...
Seoul virus (SEOV) poses a worldwide public health threat.This virus, which is harbored by Rattus norvegicus and R. rattus rats, the causative agent of hemorrhagic fever with renal syndrome (HFRS) in humans, has been reported Asia, Europe, Americas, Africa.Defining SEOV genome sequences plays critical role development preventive therapeutic strategies against unique hantavirus.We applied multiplex PCR-based next-generation sequencing to obtain from clinical reservoir host...
The purpose of this study was to investigate the antioxidant and anti‐inflammatory effects combined extract Rhei rhizoma Coptidis (RC‐mix) in experimental model acute reflux esophagitis. activity assessed by vitro 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS) assays. RC‐mix given at 100, 200, 400 mg/kg body weight 2 h prior induction esophagitis (RE). After 5 h, treated rats were compared with those normal control rats. representative...
Two new neolignans, myrifralignans F-G (14 and 18), four diarylnonanoid derivatives, myrifragranones A-D (21-24), 18 known compounds were isolated structurally elucidated from nutmeg (Myristica fragrans Houtt.) seeds. The absolute configurations of these secondary metabolites determined using the electronic circular dichroism technique. inhibitory potential on soluble epoxide hydrolase (sEH) was investigated for first time. Among them, malabaricones B C (19 20) 21-24 displayed activities...
<i>Objectives:</i> The study was aimed to investigate the relationship between plasma transforming growth factor beta 1 (TGF-β<sub>1</sub>) expression and characteristics of hepatocellular carcinoma (HCC). <i>Methods:</i> Five hundred seventy-one patients with HCC were subjected. Plasma TGF-β<sub>1</sub> levels measured by enzyme-linked immunosorbent assay at diagnosis compared in accordance clinical radiological characteristics....
In the present study, ten alkaloids, namely chabamide (1), pellitorine (2), retrofractamide A (3), pyrroperine (4), isopiperolein B (5), piperamide C9:1 (8E) (6), 6,7-dehydrobrachyamide (7), 4,5-dihydropiperine (8), dehydropipernonaline (9), and piperine (10), were isolated from fruits of Piper nigrum. Among these, (7) exhibited significant inhibitory activity on lipopolysaccharide-induced nitric oxide (NO) production in RAW264.7 cells, with IC50 values 6.8, 14.5, 30.2, 23.7, 38.5 μM,...