A5077305823- Natural product bioactivities and synthesis
- Microbial Natural Products and Biosynthesis
- Fungal Biology and Applications
- Crystallization and Solubility Studies
- Marine Sponges and Natural Products
- X-ray Diffraction in Crystallography
- Phytochemistry and Biological Activities
- Sesquiterpenes and Asteraceae Studies
- Microbial Metabolism and Applications
- Essential Oils and Antimicrobial Activity
- Microplastics and Plastic Pollution
- RNA and protein synthesis mechanisms
- Biological Activity of Diterpenoids and Biflavonoids
- Enzyme Catalysis and Immobilization
- biodegradable polymer synthesis and properties
- Phytochemical compounds biological activities
- Bioactive natural compounds
- Alkaloids: synthesis and pharmacology
- Traditional and Medicinal Uses of Annonaceae
- Structural Engineering and Vibration Analysis
- Berberine and alkaloids research
- Polymer composites and self-healing
- Effects of Vibration on Health
- Synthesis and properties of polymers
- Phytochemical Studies and Bioactivities
Ulsan National Institute of Science and Technology
2023-2025
Korea University
1989-2024
The onion, known as the bulb onion or common is not only a key ingredient in many tasty and healthy vegetarian meals but also traditional medicines. Nine new flavonoids [cepaflavas A, B (5, 6), cepadials A–D (7–9 14), cepabiflas A–C (10–12)] six compounds (1–4, 13, 15) were obtained from outer skins of Allium cepa L. Among them, 5, 6, 9 might be artificial products formed during extraction isolation. New structurally elucidated using various spectroscopy/spectrometry techniques, including...
Chitosan is a versatile bioactive polysaccharide in various industries, such as pharmaceuticals and environmental applications, owing to its abundance, biodegradability, biocompatibility, antibacterial properties. To effectively harness potential for purposes, it crucial understand the mechanisms of interaction water. This study investigates interactions between high molecular weight (HMW, >150 kDa) chitosan four different functionalized self-assembled monolayers (SAMs) at three pHs (3.0,...
Three new guaianolide lactones (1-3) and four 9-oxonerolidol glucosides (5-8) together with 20 known compounds were isolated from the MeOH extract of flowers Chrysanthemum indicum. Their structures elucidated based on interpretation NMR, HRESIMS, electronic circular dichroism (ECD) data along acid hydrolysis. Of isolates, sesquiterpenoids 1-4 15 flavones 17 18 exhibited inhibitory effects lipopolysaccharide (LPS)-induced nitric oxide production in RAW 264.7 cells IC50 values range 0.2-27.0 μM.
Twelve metabolites were obtained from the culture media of Chaetomium nigricolor, including a new furan derivative, methyl succinyl Sumiki's acid (1), and two atropisomers previously reported bis-naphtho-γ-pyrones, (aS)-asperpyrone A (aS)-fonsecinone (2 3). The structures elucidated by spectroscopic, chemical, chiroptical techniques. Compounds 2 3 inhibited nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages. Compound was found to inhibit nuclear factor-kappa B...
Three new pimarane diterpenoids, libertellenones U–W (1–3), together with libertellenone C (4) and myrocin A (5) were isolated from an EtOAc-extract of Apiospora arundinis culture medium. The chemical structures the compounds elucidated using MS, NMR, CD spectroscopic data. Benign prostatic hyperplasia (BPH), abnormal pathological proliferation epithelial stromal cells in tissues, is a common disease middle-aged elderly men. In this study, anti-BPH effects evaluated BPH-1 WPMY-1 cells....
Bioactivity-guided isolation of a MeOH extract Aralia cordata led to the four new ent-pimarane diterpenoids (1–4) and diacetylene (5) together with 21 known compounds (6–26). Their structures were established based on interpretation one- two-dimensional NMR HRESIMS data. The absolute configurations isolates determined by electronic circular dichroism data analysis, single crystal X-ray diffraction, Mosher's esterification method. All exhibited inhibitory effects lipopolysaccharide-induced...
Recently, the desire for a safe and effective method skin whitening has been growing in cosmetics industry. Commonly used tyrosinase-inhibiting chemical reagents exhibit side effects. Thus, recent studies have focused on performing melanin decolorization with enzymes as an alternative due to low toxicity of their ability decolorize selectively. Herein, 10 different isozymes were expressed recombinant lignin peroxidases (LiPs) from Phanerochaete chrysosporium (PcLiPs), PcLiP isozyme 4...
Polyhydroxyalkanoates (PHA) have emerged as a promising bio-compound in the industrial application due to their potential replace conventional petroleum-based plastics with sustainable bioplastics. This study focuses on Halomonas sp. YJPS3-3, halophilic bacterium, and presents novel approach enhance PHA production by exploiting its salt tolerance toward biosynthesis. Through gamma irradiation-induced mutants enhanced from 15% NaCl 20% NaCl, mutant halo6 showing significant 11% increase...
Recently, microorganisms and their metabolites in the Antarctic marine environment have attracted attention as useful sources for novel therapeutics, including anticancer drugs. Here, we investigated effects of citromycin, isolated from marine-derived fungus, Sporothrix sp., on human ovarian cancer cells. Citromycin inhibited migration invasion SKOV3 A2780 cells, but had no cytotoxic activity against them. Additionally, it expression epithelial–mesenchymal transition (EMT) markers activation...
Cudraisoflavone J (1), isolated from Cudrania tricuspidata, is a potent neuroprotective compound with chiral center. Herein, we report the first total synthesis of racemic cudraisoflavone (1) using Claisen rearrangement and Suzuki coupling reaction as key steps. Racemic secondary alcohol was kinetically resolved to give (+)- (−)-cudraisoflavone up 97 88% enantiomeric excess, respectively. The modified Mosher's method used elucidate absolute configuration naturally occurring J.
Chemical investigation of the Antarctic lichen-derived fungal strain Acremonium sp. SF-7394 yielded a new amphilectane-type diterpene, acrepseudoterin (1), and acorane-type sesquiterpene glycoside, isocordycepoloside A (2). In addition, three known metabolites, (−)-ternatin (3), [D-Leu]-ternatin (4), pseurotin (5), were isolated from EtOAc extract strain. Their structures mainly elucidated by analyzing their NMR MS data. The absolute configuration 1 was proposed electronic circular dichroism...
In an effort to activate silent biosynthetic gene clusters, Streptomyces samsunensis DSM42010, a producer of geldanamycin, was cultured at four different pHs (4.5, 5.4, 6.6, and 7.4). An acidic culture condition (pH 5.4) selected for chemical investigation since S. showed metabolic profile compared when it under other conditions. Seven new (1-7) known (8-11) compounds were isolated from these cultures. The structures the determined by spectroscopic techniques derivatization. Relative...
Polyurethanes (PUs) consisting of m-xylylene diisocyanate (XDI) exhibit excellent thermal stability and optical properties. To further enhance the properties, 1,3-bis(isocyanatomethyl)cyclohexane (H6XDI) is considered a potential isocyanate for optically clear adhesives; however, detailed analysis adhesion mechanism has not been investigated. Herein, we synthesized PUs using diisocyanates (XDI, H6XDI) polyols [polypropylene glycol (PPG), polycaprolactone diol (PCL), polycarbonate (PCD)]....
A new chromone analogue (1) was isolated from an EtOAc-extract of Pleosporales sp. culture medium, together with five known chromones (2 – 6). The isolation workflow guided by a Molecular Networking-based dereplication strategy. chemical structure the compound elucidated using NMR and MS spectroscopy, absolute configuration established Mosher"s method. All compounds were evaluated for their inhibitory effects on lipopolysaccharide-induced nitirc oxide production in RAW 264.7 macrophages....