A5083823940- Vector-borne infectious diseases
- Viral Infections and Vectors
- Vector-Borne Animal Diseases
- Insect and Pesticide Research
- Insect symbiosis and bacterial influences
- Mosquito-borne diseases and control
- Toxin Mechanisms and Immunotoxins
- Animal Disease Management and Epidemiology
- Zoonotic diseases and public health
- vaccines and immunoinformatics approaches
- Insect and Arachnid Ecology and Behavior
- Insect Resistance and Genetics
- Entomopathogenic Microorganisms in Pest Control
- Dermatological diseases and infestations
- Fire effects on ecosystems
- Bartonella species infections research
- Viral Infections and Outbreaks Research
- Heat shock proteins research
- Veterinary Practice and Education Studies
- Microbial infections and disease research
- Bacillus and Francisella bacterial research
- Plant and Fungal Interactions Research
- Agriculture and Farm Safety
- Parasitic Infections and Diagnostics
- T-cell and B-cell Immunology
Freie Universität Berlin
2016-2025
Onderstepoort Veterinary Institute
2024
Riemser Pharma (Germany)
2023
Utrecht University
2003-2012
University of Pretoria
2003-2004
Onderstepoort Veterinary Academic Hospital
2003-2004
Tick infestation is the major problem for animal health that causes substantial economic losses, particularly in tropical and subtropical countries. To better understand spatial distribution of tick species risk factors associated with prevalence livestock Pakistan, ticks were counted collected from 471 animals, including 179 cattle, 194 buffaloes, 80 goats 18 sheep, on 108 farms nine districts, covering both semi-arid arid agro-ecological zones.In total, 3,807 representing four collected:...
Crimean Congo hemorrhagic fever (CCHF) is a re-emerging tick-borne zoonosis that caused by CCHF virus (CCHFV). The geographical distribution of the disease and factors influence its occurrence are poorly known. We analysed historical records on outbreaks in various countries across sub-Saharan Africa (SSA) to identify hotspots determine socioecological demographicfactors associated with these outbreaks. used data from were reported between 1981 2022 SSA. To develop common framework for...
Following an outbreak of autochthonous canine babesiosis in the Netherlands, a request made to veterinarians and public collect ticks from companion animals resulted 4298 submitted between July 2005 October 2006 our center. Ticks were identified as Ixodes ricinus adults (2907/4298, 67.6%), sp. nymphs (529/4298, 12.3%) larvae (385/4298, 9.0%), I. hexagonus (328/4298, 7.6%), Dermacentor reticulatus (72/4298, 1.7%), several other exotic tick species such Amblyomma flavomaculatum (formerly...
For accurate and reliable gene expression analysis, normalization of data against reference genes is essential. In most studies on ticks where (semi-)quantitative RT-PCR employed, occurs with a single gene, usually β-actin, without validation its presumed stability. The first goal this study was to evaluate the stability commonly used in Rhipicephalus appendiculatus (Boophilus) microplus ticks. To demonstrate usefulness these results, an unresolved issue tick vaccine development examined....
Tick-borne diseases (TBDs) have a large impact on animal health and the livelihood of livestock owners, particularly in developing countries. Although climatic ecological conditions Pakistan may favour transmission tick-borne pathogens (TBPs), only few systematic studies been carried out TBPs that they cause this country. To improve our understanding distribution TBPs, 3,807 ticks were collected from ruminants (n = 369) 108 farms (semi-arid zone 36, arid 72) Punjab Province. After...
ABSTRACT A novel Babesia species, designated bicornis sp. nov., was identified in three black rhinoceroses ( Diceros ) that died wildlife areas Tanzania and South Africa. Screening of Africa revealed, addition to B. , a second parasite, Theileria nov.
ABSTRACT Pathogen DNA was isolated from roan antelope ( Hippotragus equinus ), sable niger greater kudu Tragelaphus strepsiceros and common gray duiker Sylvicapra grimmia ) in South Africa whose deaths were attributed to either theileriosis or cytauxzoonosis. We developed Theileria species-specific probes used combination with reverse line blot hybridization assays identified three different species of four African species. The close phylogenetic relationship between members the genera...
Summary Q fever has emerged as an important human and veterinary public health problem in the Netherlands with major outbreaks three consecutive years. Goat farms are probably prime source from which Coxiella burnetii have spread throughout environment, infecting people living vicinity. infection not only spilled over animal husbandry to humans but could also neighbouring wildlife pets forming novel reservoirs consequently posing another lingering threat humans, companion animals livestock....
Tick-borne diseases (TBDs) cause significant losses among livestock and impact the livelihoods of resource-poor farming communities worldwide. In Ethiopia, detailed studies on epidemiology tick-borne pathogens (TBPs) in cattle using sensitive molecular detection methods are scarce. The objective this study was to determine prevalence species composition bovine TBPs veterinary significance local populations. A comprehensive cross-sectional epidemiological conducted populations Illubabor zone...
Culicoides spp. play an important role in the transmission of several vector-borne pathogens such as Bluetongue and Schmallenberg virus Europe. To better understand biology local species, a study divided into three parts was performed northeast Germany to elucidate feeding activity patterns (study A), preferential landing sites B) host preferences C) using cattle sheep baits. In A, monitored over 72 h period by collecting insects at regular intervals from interior drop traps with or standing...
Abstract Background The bacterium Coxiella burnetii is the etiological agent of Q fever and mainly transmitted via inhalation infectious aerosols. DNA C. frequently detected in ticks, but role ticks as vectors epidemiology this still controversial. In study, Ixodes ricinus Dermacentor marginatus adults well I. nymphs were fed on blood spiked with order to study fate within putative tick vectors. Methods Blood-feeding experiments performed vitro silicone-membrane based feeding units. uptake,...
The use of RNA interference (RNAi) to assess gene function has been demonstrated in several three-host tick species but adaptation RNAi the one-host tick, Boophilus microplus, not reported. We evaluated application B. microplus and effect silencing on three tick-protective antigens: Bm86, Bm91 subolesin. Gene-specific double-stranded (dsRNA) was injected into two stages, freshly molted unfed engorged females, specific confirmed by real time PCR. Gene occurred females after they were allowed...
Subolesin is an evolutionary conserved protein that was discovered recently in Ixodes scapularis as a tick protective antigen and has role blood digestion, reproduction development. In other organisms, subolesin orthologs may be involved the control of developmental processes. Because profound effect knockdown ticks we hypothesized plays gene expression, therefore affects multiple cellular The objective this study to provide evidence for expression. Two subolesin-interacting proteins were...
Abstract Background Anaplasma marginale is an obligate intracellular bacterium and the main cause of bovine anaplasmosis in tropical subtropical regions. In Egypt, data regarding prevalence A. ruminant hosts circulating genotypes lacking. This study therefore aimed to (i) investigate presence, epidemiology cattle buffaloes (ii) evaluate suitable diagnostic tools (iii) identify co-infections with other selected tick-borne pathogens. Methods Blood samples were collected from 394 animals (309...
Hepatozoon canis is a protozoal agent that known to be transmitted by oral uptake of H. canis-infected Rhipicephalus sanguineus sensu lato ticks in dogs. Vertical transmission has only been described once study evaluating dogs from Japan. The aim this was investigate the parasitological status puppies bitch had tested positive for spp. prior giving birth.
Abstract Background Hyalomma marginatum and H. rufipes are two-host tick species, which mainly distributed in southern Europe, Africa to central Asia but may also be found Central Northern Europe through introduction by migratory birds. Methods Ticks were collected while feeding or crawling on animals humans, from the environment, different regions Germany, between 2019 2021 a citizen science study 2022 2023 wake of this study. Results From 2023, total 212 adult ticks detected Germany. This...
Tropical theileriosis is a fatal leukemic-like disease of cattle caused by the tick-transmitted protozoan parasite Theileria annulata . The economics meat and milk production severely affected in endemic areas. hydroxynaphtoquinone buparvaquone (BPQ) only available drug currently used to treat clinical theileriosis, whilst BPQ resistance emerging spreading Here, we chronically exposed T -transformed macrophages vitro monitored emergence drug-resistant parasites. Surviving parasites revealed...