A5101531043- Complex Systems and Time Series Analysis
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Financial Risk and Volatility Modeling
- Colorectal and Anal Carcinomas
- Heat shock proteins research
- Complex Network Analysis Techniques
- Opinion Dynamics and Social Influence
- Nonlinear Dynamics and Pattern Formation
- Hormonal Regulation and Hypertension
- Theoretical and Computational Physics
- Obstructive Sleep Apnea Research
- Human Mobility and Location-Based Analysis
- Cancer, Stress, Anesthesia, and Immune Response
- stochastic dynamics and bifurcation
- Time Series Analysis and Forecasting
- UAV Applications and Optimization
- Chaos control and synchronization
- Neural Networks and Applications
- Privacy-Preserving Technologies in Data
- Telecommunications and Broadcasting Technologies
- Millimeter-Wave Propagation and Modeling
- Heart Failure Treatment and Management
- Radio Wave Propagation Studies
- Transportation Planning and Optimization
Saitama Prefecture
2025
Mie University Hospital
2024
Juntendo University
2019-2024
Yokohama City University
2019-2024
National Cancer Center Hospital East
2009-2024
SoftBank Group (Japan)
2019-2023
Kitami Institute of Technology
2022-2023
National Institute of Advanced Industrial Science and Technology
2023
Research Institute for Brain and Blood Vessels Akita
2022
Remote Sensing Technology Center of Japan
2021
The study objective was to evaluate the efficacy and toxicity of chemoradiotherapy with 5-fluorouracil (5-FU) plus cisplatin in patients Stage I esophageal squamous cell carcinoma (ESCC). primary endpoint proportion complete response (%CR).Patients (T1N0M0) ESCC, aged 20-75 years, without indication endoscopic mucosal resection were eligible. Treatment consisted 70 mg/m(2) (day 1) 5-FU 700 mg/m(2)/day (days 1-4) combined 30 Gy radiotherapy (2 Gy/day, 5 days/week, days 1-21). cycle repeated...
A general discrete stochastic process involving random amplification with additive external noise is analyzed theoretically and numerically. Necessary sufficient conditions to realize steady power law fluctuations divergent variance are clarified. The exponent determined by a statistical property of independent the noise. By introducing nonlinear effect stretched exponential decay appears in law.
Hepatitis C virus (HCV) infection induces a wide range of chronic liver injuries. The mechanism by which HCV evades the immune surveillance system remains obscure. Blood dendritic cells (DCs) consist myeloid and plasmacytoid subsets that play distinct roles in regulation antivirus responses; however, their pathogenesis are yet to be determined. We compared numbers functions DCs between 43 patients with hepatitis 26 age-matched healthy volunteers. Absolute DCs, DC progenitors periphery were...
We established hepatitis C virus (HCV) core-expressing cells and investigated whether HCV core would modify the Janus kinase (JAK)-signal transducer activator transcription factor (STAT) pathway under interleukin-6 (IL-6) interferon (IFN)-gamma stimuli. Phosphorylation of JAK1/2 STAT3, STAT3-mediated transcription, were prevented by IL-6 stimulation. In contrast, increased phosphorylation STAT1 STAT1-mediated IFN-gamma Immunoprecipitation/Western blot analysis showed that could bind to...
Astaxanthin has strong antioxidant properties. We conducted a prospective pilot study on heart failure (HF) patients with left ventricular (LV) systolic dysfunction to investigate improvements in cardiac function and exercise tolerance relation suppression of oxidative stress by 3-month astaxanthin supplementation. Oxidative markers—serum Diacron reactive oxygen metabolite (dROM), biological potential (BAP), urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) concentrations, LV ejection fraction...
Abstract Background PI3K/AKT/mTOR pathway is frequently overactive in esophageal squamous cell carcinoma (ESCC), making it an attractive treatment target. BKM120 oral pan-class I PI3K inhibitor with promising activity several cancers. We prospectively investigated efficacy, safety, and biomarkers of advanced ESCC. conducted a multicenter phase II study monotherapy patients pretreated Methods (100 mg/day) was administered orally 28-day cycle. The primary end point disease control rate (DCR)....
In this multicenter, prospective, test-negative, case-control study in Japan, the effectiveness of both BA.1-containing and BA.4/BA.5-containing bivalent coronavirus disease 2019 mRNA vaccines against symptomatic infection during BA.5-dominant period was high compared with no vaccination (65% 76%) moderate monovalent administered over half a year earlier (46% combined).
ABSTRACT Paced QRS duration ≥ 150 ms is associated with pacing‐induced cardiomyopathy (PICM). However, there no established method for conventional stylet‐driven pacing lead placement to achieve a narrow duration. We placed on the right ventricular inflow tract (RVIT) mid‐septum using manually shaped three‐dimensional (3D) stylet and three‐directional fluoroscopic guidance in 9 consecutive patients complete or advanced atrioventricular block normal left systolic function. The median paced...
In patients with heart failure (HF), the impact of Geriatric Nutritional Risk Index (GNRI) on in-hospital mortality and length hospital stay remains unclear. We aimed to identify factors associated increased longer considering GNRI in acute decompensated HF reduced preserved ejection fraction (HFrEF HFpEF, respectively). Patients who were admitted our institution between 2007 2011 investigated. A total 451 (201, HFrEF; 250, HFpEF) divided into following: < 92 ≥92. HFrEF, there no significant...
Multi-parametric assessment, including heart sounds in addition to conventional parameters, may enhance the efficacy of noninvasive telemonitoring for failure (HF). We sought assess feasibility self-telemonitoring with multiple devices a handheld sound recorder and its association clinical events patients HF.
The 78-kDa glucose-regulated protein GRP78, also known as HSPA5 or BiP, is a heat shock 70 family member that promotes functions of the endoplasmic reticulum, such folding and assembly, prevention aggregation misfolded proteins, translocation secreted initiation unfolded response. GRP78 may be cancer marker. When small extracellular vesicles containing are released from cells, recipient cells exhibit enhanced malignant progression angiogenesis. Further, has critical role in infectious...
The TCB index (triglycerides × total cholesterol body weight), a novel simply calculated nutritional based on serum triglycerides (TGs), (TC), and weight (BW), was recently reported to be useful prognostic indicator in patients with coronary artery disease. Thus, this study aimed investigate the relationship between TCBI long-term mortality acute decompensated heart failure (ADHF) patients. Patients diagnosis of ADHF who were consecutively admitted cardiac intensive care unit our institution...
The installation process of numerous Bluetooth Low Energy (BLE) beacons in the indoor positioning environment usually requires manual measurement beacon's physical coordinates which tends to be a labor-intensive process. In this work, we aim create BLE beacon map by obtaining their from situ Received Signal Strength (RSS) observations on smartphone short period time. This paper proposes method automatic localization for twin based Range-Only Simultaneous Localization and Mapping (RO-SLAM)...
Repeated emergence of variants with immune escape capacity and waning immunity from vaccination are major concerns for COVID-19. We examined whether the surge in Omicron subvariant BA.5 cases was due to or through vaccine effectiveness (VE) evaluation.A test-negative case-control study conducted 16 clinics/hospitals during BA.1/BA.2-dominant BA.5-dominant periods. VE against symptomatic infection estimated after adjusting age, sex, comorbidity, occupation, testing frequency, prior infection,...
Abstract Aims Although both hypercapnia and hypocapnia are common in acute heart failure (AHF) patients, routine assessment of arterial blood gas is not recommended. Additionally, no association between increased mortality has been found, the prognostic value AHF patients remains to be elucidated. In this observational study, we aimed investigate relationship partial pressure carbon dioxide (PaCO2), especially low PaCO2, long-term patients. Methods results Acute hospitalized cardiac...
5545 Background: Olaparib, a PARP inhibitor, is effective as maintenance therapy for newly diagnosed BRCA-mutated or homologous recombination deficiency (HRD)-positive advanced ovarian cancer and in platinum-sensitive recurrent cancer. Preclinical studies suggest synergy between inhibitors immune checkpoint inhibitors, with demonstrated efficacy patients. However, the safety of this combination neoadjuvant remain uncertain. Methods: This open-label, multicenter pilot study evaluated olaparib...