A5101457424- RNA Research and Splicing
- Mental Health Research Topics
- RNA modifications and cancer
- Functional Brain Connectivity Studies
- Software Engineering Research
- Peptidase Inhibition and Analysis
- Pharmacological Effects of Natural Compounds
- Dementia and Cognitive Impairment Research
- 14-3-3 protein interactions
- NF-κB Signaling Pathways
- Wnt/β-catenin signaling in development and cancer
- Cancer Treatment and Pharmacology
- Bioactive Natural Diterpenoids Research
- Health, Environment, Cognitive Aging
- Sphingolipid Metabolism and Signaling
- Topic Modeling
- Machine Learning in Healthcare
- Autonomous Vehicle Technology and Safety
- Lipid metabolism and biosynthesis
- Software System Performance and Reliability
- Industrial Vision Systems and Defect Detection
- Cell death mechanisms and regulation
- Retinoids in leukemia and cellular processes
- Phosphorus compounds and reactions
- Origins and Evolution of Life
Kunming Medical University
2025
Wuhan University of Technology
2023
Case Western Reserve University
2017-2022
Capital Medical University
2020-2022
Beijing YouAn Hospital
2022
Tencent (China)
2020
Ocean University of China
2016
Children's Hospital of Los Angeles
2007
Nanyang Medical College
2002
Cognitive decline is amongst one of the most commonly reported complaints during normal aging. Despite evidence that age and cognition are linked with similar neural correlates, no previous studies have directly ascertained how these two constructs overlap in brain terms neuroimaging-based prediction. Based on a long lifespan healthy cohort (CamCAN, aged 19-89 years, n = 567), it shown both cognitive function (domains spanning executive function, emotion processing, motor memory) human can...
Predictive modeling of neuroimaging data (predictive neuroimaging) for evaluating individual differences in various behavioral phenotypes and clinical outcomes is growing interest. However, the field experiencing challenges regarding interpretability results. Approaches to defining specific contribution functional connections, regions, or networks prediction models are urgently needed, which may help explore underlying mechanisms. In this article, we systematically review methods...
The breakdown of stored fat deposits into its components is a highly regulated process that maintains plasma levels free fatty acids to supply energy cells. Insulin-mediated transcription Atgl, the enzyme mediates rate-limiting step in lipolysis, key point this regulation. Under conditions such as obesity or insulin resistance, Atgl often misregulated, which can contribute overall disease progression. mechanisms by induced during adipogenesis are not fully understood. We utilized...
Representation learning stands as one of the critical machine techniques across various domains. Through acquisition high-quality features, pre-trained embeddings significantly reduce input space redundancy, benefiting downstream pattern recognition tasks such classification, regression, or detection. Nonetheless, in domain tabular data, feature engineering and selection still heavily rely on manual intervention explanation, leading to time-consuming processes necessitating expertise. In...
Highlights•SNAT2 activity mediates biphasic translational control in osmoadaptation•Early-phase stress inhibits translation and induces distinct RBP condensates•Late-phase SNAT2-mediated uptake of amino acids reverses inhibition•SNAT2 disassembles early-phase condensatesSummaryThe integrated response (ISR) plays a pivotal role adaptation machinery to cellular stress. Here, we demonstrate an ISR-independent osmoadaptation mechanism involving reprogramming via coordinated but independent...
For large industrial applications, system test cases are still often described in natural language (NL), and their number can reach thousands. Test automation is to automatically execute the cases. Achieving typically requires substantial manual effort for creating executable scripts from these NL In particular, given that each case consists of a sequence steps, testers first implement API method step then write script invoking methods sequentially automation. Across different cases,...
SUMMARY OBJECTIVE ADAMTS4 is a member of the family, which secretes proteinases. The mechanism tumor metastasis may be correlated to its promotion angiogenesis. It was determined whether participates in colorectal cancer progression. Methods expression clinical samples and CRC cell lines investigated. Using immunohistochemistry (IHC), fluorescence situ hybridization (FISH), RT-PCR, tumors different stages anatomic sites, three aggressiveness. Results overexpression observed tissue by IHC,...
Ingenol mebutate possesses significant cytotoxicity and is clinically used to treat actinic keratosis. However, ingenol undergoes acyl migration which affects its bioactivity. Compound 3-O-angeloyl-20-O-acetyl (AAI, also known as 20-O-acetyl-ingenol-3-angelate or PEP008) a synthetic derivative of mebutate. In this work, we report the AAI synthesis details demonstrate has higher than in chronic myeloid leukemia K562 cell line. Our data indicate that increased activity originates from improved...
Considering the complexity of driving environment and high uncertainty road conditions in autonomous driving, this paper proposes a real-time object detection model YOLOv5st, which is integration advantages YOLOv5s Swin Transformer to achieve image recognition tasks perception. The proposed YOLOv5st tested on Transportation Wuhan China (TOWC) traffic dataset, results show that mean Average Precision (mAP) 89.8% validation set, 2.0% improvement compared YOLOv5s. And average inference time...