A5101791823- Heart Rate Variability and Autonomic Control
- Cardiac electrophysiology and arrhythmias
- Vagus Nerve Stimulation Research
- Ion channel regulation and function
- Mental Health Treatment and Access
- Cardiac Ischemia and Reperfusion
- Child and Adolescent Psychosocial and Emotional Development
- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Cardiac Arrest and Resuscitation
- Bipolar Disorder and Treatment
- Workplace Health and Well-being
- Mental Health and Psychiatry
- Radioactive contamination and transfer
- Cardiac Arrhythmias and Treatments
- Risk Perception and Management
- Schizophrenia research and treatment
- Posttraumatic Stress Disorder Research
- EEG and Brain-Computer Interfaces
- Attention Deficit Hyperactivity Disorder
- Disaster Response and Management
- Pain Mechanisms and Treatments
- Psychiatric care and mental health services
- Neurotransmitter Receptor Influence on Behavior
Sartorius (United States)
2014-2024
National Cerebral and Cardiovascular Center
2014-2024
NTT Medical Center
2015-2024
Kyoto Institute of Technology
2018-2021
Harvard University
2021
Massachusetts General Hospital
2021
Suzuki (Japan)
2021
Suita Municipal Hospital
2019
NTT (Japan)
2012
National Institute of Mental Health
2011
Background. Little is known about the bacteriology of pericolostomic skin region. Identifying these bacteria important to reduce morbidity resulting from this procedure both control local infection and risk in other surgical sites.The scope study was determine prevalence type peristomal colostomy patients.Thirty-four patients with a temporary were included study. Their mean age 51.6 years. All had been colostomized for more than 7 weeks.Tissue samples obtained cultured. Escherichia coli...
Reliable, clinically useful, and globally applicable diagnostic classification of mental disorders is an essential foundation for global health. The World Health Organization (WHO) nearing completion the 11th revision International Classification Diseases Related Problems (ICD‐11). present study assessed inter‐diagnostician reliability accounting greatest proportion disease burden highest levels service utilization – schizophrenia other primary psychotic disorders, mood anxiety fear‐related...
In this paper we report the clinical utility of diagnostic guidelines for ICD-11 mental, behavioural and neurodevelopmental disorders as assessed by 339 clinicians in 1,806 patients 28 mental health settings 13 countries. Clinician raters applied schizophrenia other primary psychotic disorders, mood (depressive bipolar disorders), anxiety fear-related specifically associated with stress. ratings proposed were very positive overall. The perceived easy to use, corresponding accurately...
Our recent studies have shown that, as indicated by vagal stimulation, an acetylcholinesterase inhibitor donepezil, anti‐Alzheimer’s disease drug, prevents progression of heart failure in rats with myocardial infarction, and activates a common cell survival signal shared acetylcholine (ACh) vitro . On the basis this evidence that innervation is extremely poor left ventricle, we assessed hypothesis ACh produced cardiomyocytes, which promotes its synthesis via positive feedback mechanism. Rat...
<i>Background:</i> A number of psychopathological and neurobiological studies on affective temperament have been conducted based the assumption that is a stable trait. However, few actually assessed long-term stability temperament. The objective this study to evaluate 6-year temperaments as measured by Temperament Evaluation Memphis, Pisa, Paris San Diego – Autoquestionnaire version (TEMPS-A) in non-clinical adult population. <i>Sampling Methods:</i> Study...
Background Murine and human ventricular cardiomyocytes rich in acetylcholine ( Ach ) receptors are poorly innervated by the vagus, compared with whole innervation adrenergic nerve. However, vagal nerve stimulation produces a favorable outcome even murine heart, despite relatively low cholinergic density. Such mismatch missing link suggest existence of nonneuronal system myocardium. Methods Results To examine role cardiac system, we generated choline acetyltransferase ChAT )–expressing cells...
Background In our previous study, we established the novel concept of a non-neuronal cardiac cholinergic system–cardiomyocytes produce ACh in an autocrine and/or paracrine manner. Subsequently, determined biological significance this system–it played critical role modulating mitochondrial oxygen consumption. However, its detailed mechanisms and clinical implications have not been fully investigated. Aim We investigated if system was upregulated by modality other than drugs activation...
Abstract Linkage of bipolar disorder with 18p11 has been replicated by several investigators. A nuclear‐encoded mitochondrial complex I subunit gene, NDUFV2 , is one the candidate genes in this locus, since possible pathophysiological significance dysfunction suggested. The objective our study was to clarify association between gene and disorder. We performed real‐time quantitative reverse transcription polymerase chain reaction (RT‐PCR) for mRNA expression lymphoblastoid cell lines derived...
Altered Ca2+ signalling has been reported in the platelets and lymphoblastoid cells of patients with bipolar disorder. Recent genetic studies have suggested possible pathophysiological roles for mitochondria endoplasmic reticulum, both which are essential regulation intracellular signalling. The goal this study was to determine molecular mechanisms altered Lymphoblastoid cell lines were established from I disorder (n=13) controls (n=11). Using indicators, cytosolic mitochondrial responses...
The present study aimed to clarify the associations among radiation exposure or psychological Fukushima nuclear power plant accident (i.e., fear/anxiety immediately after accident), current anxiety, and distress non-evacuee community residents in five years Great East Japan Earthquake, which occurred March 2011. A questionnaire survey was administered a random sample of from 49 municipalities prefecture February April 2016, data 1684 respondents (34.4%) were analyzed. Environmental levels at...
Abstract Objective The purpose of this study was to explore the experiences municipal public health nurses in wake March 2011 massive earthquake and tsunami resulting nuclear accident F ukushima, J apan, from time disaster until December 2013. Design Sample Thirty‐two working three cities Fukushima prefecture were divided into four focus groups took part interviews, which analyzed using a qualitative descriptive method. Results Two major themes extracted: (1) difficulties dilemmas, (2)...