A5017867533- Heart Rate Variability and Autonomic Control
- Vagus Nerve Stimulation Research
- Anesthesia and Pain Management
- Nausea and vomiting management
- Contact Dermatitis and Allergies
- Non-Invasive Vital Sign Monitoring
- Cardiovascular Syncope and Autonomic Disorders
- Neuropeptides and Animal Physiology
- Anesthesia and Neurotoxicity Research
- Allergic Rhinitis and Sensitization
- Hydrogen's biological and therapeutic effects
- Biochemical effects in animals
- Cancer, Stress, Anesthesia, and Immune Response
- Neuroscience of respiration and sleep
- Enhanced Recovery After Surgery
- Therapeutic Uses of Natural Elements
- Cardiovascular and exercise physiology
- Skin Protection and Aging
- Ocular Surface and Contact Lens
- Simulation-Based Education in Healthcare
- EEG and Brain-Computer Interfaces
- Acupuncture Treatment Research Studies
- Dermatology and Skin Diseases
- Cellular Mechanics and Interactions
- Occupational exposure and asthma
Sanyo-Onoda City University
2020
Kitasato University
2010-2019
Pharmaceuticals and Medical Devices Agency
2006
National Cerebral and Cardiovascular Center
2005
Fukuoka University
1998-2002
Pharmac
1999
Sympathetic activation during orthostatic stress is accompanied by a marked increase in low-frequency (LF, approximately 0.1-Hz) oscillation of sympathetic nerve activity (SNA) when arterial pressure (AP) well maintained. However, LF SNA development neurally mediated syncope remains unknown. Ten healthy subjects who developed head-up tilt (HUT)-induced and 10 age-matched nonsyncopal controls were studied. Nonstationary time-dependent changes calf muscle (MSNA, microneurography), R-R...
The effects of a novel tachykinin NK1-receptor antagonist HSP-117 [(2S,3S)-3-[(5-isopropyl-2,3-dihydrobenzofuran-7-yl)methyl]amino-2-phenylpiperidine dihydrochloride] on cisplatin-induced pica, i.e., the eating nonnutritive substances such as kaolin were examined in rats. inhibited intake dose-dependent manner for 2 days. 5-HT3-receptor ondansetron only first day, but not second day. These results indicate that day is related to both 5-HT3- and NK1 receptors, while receptor involved Thus,...
Although electroacupuncture reduces sympathetic nerve activity (SNA) and arterial pressure (AP), the effects of on baroreflex remain to be systematically analyzed. We investigated Zusanli using an equilibrium diagram comprised neural peripheral arcs. In anesthetized, vagotomized, aortic-denervated rabbits, we isolated carotid sinuses changed intra-carotid sinus (CSP) from 40 160 mmHg in increments 20 mmHg/min while recording cardiac SNA AP. Electroacupuncture was applied with a pulse...
Despite the accumulated knowledge of human muscle sympathetic nerve activity (SNA) as measured by microneurography, whether SNA parallels renal and cardiac SNAs remains unknown.In experiment 1, (microneurography, tibial nerve), renal, were recorded in anesthetized rabbits (n=6) while arterial pressure was changed intravenous bolus injections nitroprusside (3 microg/kg) followed phenylephrine microg/kg). In 2, carotid sinus region vascularly isolated anesthetized, vagotomized,...
Since humans are under ceaseless orthostatic stress, the mechanism to maintain arterial pressure (AP) stress against gravitational fluid shift is of great importance. We hypothesized that (1) resets baroreflex control sympathetic nerve activity (SNA) a higher SNA, and (2) resetting contributes preventing postural hypotension. Renal SNA AP were recorded in eight anaesthetized, vagotomized aortic‐denervated rabbits. Isolated intracarotid sinus (CSP) was increased stepwise from 40 160 mmHg with...
Despite accumulated knowledge on human baroreflex control of muscle sympathetic nerve activity (SNA), whether SNA parallels that other SNAs, in particular renal and cardiac remains unclear. Using urethane alpha-chloralose-anesthetized, vagotomized aortic-denervated rabbits (n = 10), we recorded from tibial by microneurography, simultaneously with SNAs wire electrode. To produce a open-loop condition, isolated the carotid sinuses systemic circulation altered intracarotid sinus pressure (CSP)...
The dynamic characteristics of the baroreflex neural arc from pressure input to efferent sympathetic nerve activity (SNA) reveal derivative in frequency range 0.01 0.8 Hz (i.e., gain augments with increasing frequency) and high-cut above decreases rabbits. accelerate arterial regulation via baroreflex. preserve against pulsatile by attenuating high-frequency components less necessary for regulation. However, what extent carotid sinus baroreceptor transduction afferent (BNA) contributes these...
DPRA (direct peptide reactivity assay) and ADRA (amino acid derivative assay), which are based on the biological events of skin sensitization, were developed as alternatives to controversial animal experiments. These assays described in OECD (Organization for Economic Co-operation Development) guideline, Test No. 442C. Although these have been endorsed by industries internationally accepted promising effective tests vitro they suffer from several drawbacks, such incompatibility with...
The biological process of skin sensitization depends on the ability a sensitizer to modify endogenous proteins. A direct peptide reactivity assay (DPRA), based sensitization, was developed as an alternative controversial animal experiments. Although DPRA has been endorsed by industries and is internationally accepted promising, it several drawbacks, such incompatibility with hydrophobic chemicals, inability perform detailed reaction analysis, evaluate only single components. Here, we...
サブスタンスP(SP)に代表されるタキキニン・ペプチド類には，NK-1，NK-2およびNK-3の3つの受容体が存在し種々の生理反応に関与している。中でもSPとNK-1受容体は延髄の最後野や弧束核に密に存在し，嘔吐に強く関与していると考えられるが，詳細な作用機序は明らかではない。そこで本研究では，嘔吐発現機構における特に延髄最後野のタキキニンNK-1受容体に注目し，新たに開発されたNK-1受容体拮抗薬HSP-117による制吐作用についてフェレットを用いて検討した。フェレットの延髄の3H-SPの結合部位は，弧束核，舌下核，迷走神経背側核，および最後野に密に分布していた。さらに最後野を含む延髄切片をSPで灌流すると，最後野の約50%の細胞に興奮反応が認められた。このSPによる神経活動興奮反応はNK-1受容体アンタゴニストのCP-99,994によって著しく抑制されたことから，フェレットの延髄最後野にNK-1受容体が存在することが明らかとなった。タキキニンNK-1受容体拮抗薬HSP-ll7とCP-99,994のNK-1受容体に対する選択性を，IM-9細胞の膜標品に対する3H-SPの結合阻害...
[Background] Periodontitis is common in adults and cardiovascular diseases (CVD) are the most cause of adult death world. Opening infarct-related coronary artery a valued therapeutic goal acute myocardial infarction (AMI), however, cardiomyocytes continue to die during reperfusion. Acute oxidative stress induced by ischemia - reperfusion causes serious damage tissue. The purpose our study was investigate that hydrogen (H2) gas has potential as an antioxidant preventive applications against injury.