A5100648951- Heart Rate Variability and Autonomic Control
- Vagus Nerve Stimulation Research
- Cardiac electrophysiology and arrhythmias
- Heart rate and cardiovascular health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Neuroscience of respiration and sleep
- Nicotinic Acetylcholine Receptors Study
- EEG and Brain-Computer Interfaces
- Non-Invasive Vital Sign Monitoring
- Neurological Disorders and Treatments
- Receptor Mechanisms and Signaling
- Cardiovascular Health and Risk Factors
- Pediatric health and respiratory diseases
- Stress Responses and Cortisol
- Hemodynamic Monitoring and Therapy
- Cardiovascular Function and Risk Factors
- Respiratory and Cough-Related Research
- Microbial infections and disease research
- Blood Pressure and Hypertension Studies
- Cardiac Structural Anomalies and Repair
- Intracranial Aneurysms: Treatment and Complications
- Cardiovascular Syncope and Autonomic Disorders
- Mechanical Circulatory Support Devices
- Pulmonary Hypertension Research and Treatments
Jilin University
2007-2025
First Affiliated Hospital of Jiangxi Medical College
2005-2025
Nanchang University
2022-2025
First Affiliated Hospital of GuangXi Medical University
2014-2024
Guangxi Medical University
2012-2024
Jilin Medical University
2024
National Cerebral and Cardiovascular Center
2015-2024
Second Affiliated Hospital of Harbin Medical University
2023
First Affiliated Hospital of Nanchang University
2022-2023
Hainan General Hospital
2023
Diminished cardiac vagal activity and higher heart rate predict a high mortality of chronic failure (CHF) after myocardial infarction. We investigated the effects electrical stimulation vagus nerve on remodeling long-term survival in an animal model CHF large infarction.Two weeks ligation left coronary artery, surviving rats were randomized to vagal- sham-stimulated groups. Using implantable miniature radio-controlled stimulator, we stimulated right for 6 weeks. The intensity was adjusted...
Intrahepatic cholangiocarcinoma is a neoplasm arising in the liver, and its incidence increasing Japan as well Western countries. Prognosis of patients with this type tumor remains unsatisfactory because no effective chemotherapeutic drugs are available, we have sensitive markers to detect early stage, it difficult identify high-risk group for disease. To clarify molecular mechanism tumorigenesis targets diagnosis treatment, analyzed global gene-expression profiles 25 intrahepatic...
Chronic obstructive pulmonary disease (COPD) is characterized by airway inflammation and associated with acute exacerbations. Macrolide antibiotics have been shown to exhibit anti-inflammatory effects in some chronic inflammatory diseases.The aim of this study was assess the effect treatment erythromycin on health outcome COPD patients.We conducted a randomized, placebo-controlled, double-blind trial for period 6 months. Thirty-six patients were randomized oral (125 mg, three times/day) or...
In an earlier study we demonstrated the beneficial effect of direct vagal electrical stimulation on cardiac remodeling and survival. reported here, attempted to reproduce enhancement through administration acetylcholinesterase inhibitor, donepezil. A rat model heart failure following extensive healed myocardial infarction was used. Compared their nontreated counterparts, rats given donepezil (5 mg/kg/day) in drinking water had a smaller biventricular weight (3.40 +/- 0.13 vs. 3.02 0.21 g/kg...
Vagal nerve stimulation has been suggested to ameliorate left ventricular (LV) remodeling in heart failure. However, it is not known whether and what degree vagal affects matrix metalloproteinase (MMP) tissue inhibitor of MMP (TIMP) myocardium, which are play crucial roles LV remodeling. We therefore investigated the effects electrical efferent on myocardial expression activation MMPs TIMPs a rabbit model ischemia-reperfusion (I/R) injury. Anesthetized rabbits were subjected 60 min coronary...
We estimated open-loop dynamic characteristics of the carotid sinus baroreflex in normal control rats and chronic heart failure (CHF) after myocardial infarction. First, neural arc transfer function from pressure to splanchnic sympathetic nerve activity (SNA) its corresponding step response were examined. Although steady-state was attenuated CHF, negative peak time did not change significantly, suggesting preserved characteristics. Next, peripheral SNA arterial (AP) The initial slope reduced...
Background: Vagal activation by electrical stimulation has been shown to improve the long-term survival of rats with chronic heart failure (CHF) after extensive myocardial infarction (MI). Acetylcholinesterase inhibition increases synaptic acetylcholine, and can disproportionately increase vagal tone. To develop an alternative therapy for CHF using a clinically available drug, present study investigated whether oral donepezil, acetylcholinesterase inhitor, could reproduce beneficial effects...
Heavy smoking can induce airway inflammation and emphysema. Macrolides modulate effector T-cell response in the lungs. However, there is no information on whether erythromycin regulatory (Treg) response. This study aimed at examining impact of Treg lungs a rat model smoking-induced Male Wistar rats were exposed to normal air or cigarette daily for 12 weeks treated by gavage with 100 mg/kg saline beginning forth week nine weeks. The lung numbers inflammatory infiltrates bronchoalveolar lavage...
Corticosteroid insensitivity, which is induced by cigarette smoke extract (CSE), a significant barrier when treating chronic obstructive pulmonary disease (COPD). Erythromycin (EM) has been shown to have an anti-inflammatory role in some airway inflammatory diseases, particularly diffuse panbronchiolitis and cystic fibrosis. Here, we explored whether the combination therapy of EM dexamethasone (Dex) reverses corticosteroid insensitivity investigated molecular mechanism this occurs. We...
The acetylcholinesterase inhibitor donepezil restores autonomic balance, reduces inflammation, and improves long-term survival in rats with chronic heart failure (CHF) following myocardial infarction (MI). As arterial hypertension is associated a significant risk of cardiovascular death, we investigated the effectiveness treating CHF spontaneously hypertensive (SHR). was induced SHR by inducing permanent MI. After 2 weeks, surviving were randomly assigned to sham-operated (SO), untreated...
The aim of this study was to assess the potential association between non-high-density lipoprotein cholesterol high-density ratio (NHHR) and type 2 diabetes mellitus (T2DM) in a middle-aged elderly Chinese population using data from China Health Retirement Longitudinal Study (CHARLS) 2011 2015. Methods We used CHARLS as baseline follow-up NHHR continuous categorical variable, multivariate logistic regression modeling explore its relationship with T2DM. Three models were developed adjust for...
Our previous study showed that chronic vagal stimulation (VS) prevented the cardiac remodeling and improved prognosis of heart failure (CHF) rats after large myocardial infraction (MI). Antiarrhythmic effects VS were assumed to produce such a beneficial outcome. There-rhythmias. fore, we examined on ar- The ECG transmitter radio-controlled stimulator implanted in healed MI rat (n=8). electrical right cervical vagus started at 3-5 months lasted for 7 days. data analyzed counting premature...
Talaromyces marneffei (T. marneffei), a dimorphic fungus, causes local or disseminated infection in humans. We aimed to analyze the clinical characteristics, prognostic factors, and survival outcomes of patients with T. compare differences between human immunodeficiency virus (HIV)-positive HIV-negative subgroups.We retrospectively analyzed 241 at First Affiliated Hospital Guangxi Medical University January 2012 2022. The overall population was stratified into HIV-positive (n = 98) 143)...
Anti-interferon-γ autoantibodies (AIGAs) syndrome is susceptible to disseminated opportunistic infections due increased AIGAs, but its clinical immunological characteristics remain unrecognized. We conducted a prospective cohort study between January 2021 and December 2023, recruiting patients with who were categorized into AIGAs-positive AIGAs-negative groups. Clinical data outcomes documented. A subset of received glucocorticoid treatment, effectiveness was evaluated. total 238 enrolled,...
Pulmonary rehabilitation (PR) is essential for treating interstitial lung disease (ILD). The 5A nursing model enhances patients' health-promoting behaviors by improving their self-management skills. aim of this study to examine and analyze the effectiveness PR program based on concerning function, dyspnea, anxiety, depression, self-efficacy, quality life, compliance in patients with ILD. 64 hospitalized ILD were enrolled quasi-experimental study. Patients randomly assigned an intervention...