A5087375503- Regulation of Appetite and Obesity
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Biochemical Analysis and Sensing Techniques
- MicroRNA in disease regulation
- Pancreatic function and diabetes
- Cancer-related molecular mechanisms research
- Retinoids in leukemia and cellular processes
- Pharmacological Effects of Natural Compounds
- Immune Response and Inflammation
- Apelin-related biomedical research
- Animal Nutrition and Physiology
- Peroxisome Proliferator-Activated Receptors
- Diet and metabolism studies
- Fibroblast Growth Factor Research
- Circadian rhythm and melatonin
- Protein Tyrosine Phosphatases
- Neurogenesis and neuroplasticity mechanisms
- Neurobiology and Insect Physiology Research
- Congenital Ear and Nasal Anomalies
- Congenital heart defects research
- Estrogen and related hormone effects
- Fatty Acid Research and Health
- Biochemical effects in animals
- Sphingolipid Metabolism and Signaling
Institut des Neurosciences Paris-Saclay
2014-2022
Centre National de la Recherche Scientifique
2012-2022
Université Paris-Saclay
2005-2022
CEA Paris-Saclay
2021
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2021
Université Paris-Sud
2005-2019
Institut Pasteur de Lille
2010-2014
Université de Lille
2010-2014
Inserm
2010-2014
European Genomic Institute for Diabetes
2014
Resistin promotes both inflammation and insulin resistance associated with energy homeostasis impairment. However, the resistin receptor molecular mechanisms mediating its effects in hypothalamus, crucial for control, key insulin-sensitive tissues are still unknown. In current study, we report that chronic infusion lateral cerebral ventricle of normal rats markedly affects hypothalamic peripheral responsiveness. Central treatment inhibited insulin-dependent phosphorylation (IR), AKT,...
The insulin-sensitive glucose transporter Glut4 is expressed in brain areas that regulate energy homeostasis and body adiposity. In contrast with peripheral tissues, however, the impact of insulin on plasma membrane (PM) translocation neurons not known. this study, we examined role two anorexic hormones (leptin insulin) a human neuronal cell line express endogenous leptin receptors. We show both induce to PM cells activate uptake. Wortmannin, specific inhibitor phosphatidylinositol 3-kinase,...
Adiponectin, an insulin-sensitizing hormone, and resistin, known to promote insulin resistance, constitute a potential link between obesity type 2 diabetes. In addition, fibroblast growth factor (FGF)21 has effects similar those of adiponectin in regulating glucose lipid metabolism sensitivity. However, the interplay adiponectin, FGF21, resistin signaling pathways during onset resistance is unknown. Here, we investigated whether central promotes through impairment FGF21 signaling. We show...
Interaction of leptin with its receptors resembles that interleukin-6 and granulocyte colony-stimulating factor, which interact their through binding sites I–III. Site III plays a pivotal role in receptors' dimerization or tetramerization subsequent activation. Leptin's site also mediates the formation an active multimeric complex interaction IGD (immunoglobulin-like domain) LEPRs (leptin receptors). Using sensitive hydrophobic cluster analysis leptin's LEPR's sequences, we identified...
Obesity is characterized by the excessive accumulation of dysfunctional white adipose tissue (WAT), leading to a strong perturbation metabolic regulations. However, molecular events underlying this process are not fully understood.MicroRNAs (miRNAs) small noncoding RNAs acting as posttranscriptional regulators gene expression in multiple tissues and organs. their roles WAT cell subtypes, which include only adipocytes but also immune, endothelial, mesenchymal stem cells well preadipocytes,...
Abstract Saturated fatty acids such as palmitic acid promote inflammation and insulin resistance in peripheral tissues, contrasting with the protective action of polyunsaturated docosahexaenoic acid. Palmitic effects have been part attributed to its potential through Toll-like receptor 4. Beside, resistin, an adipokine, also promotes via TLR4. In brain, resistin trigger neuroinflammation resistance, but their link at neuronal level is unknown. Using human SH-SY5Yneuroblastoma cell line we...
Leptin and insulin are major signals to the hypothalamus regulate energy homoeostasis body adiposity. IR (insulin receptors) leptin receptors (long isoform, ObRb) share a number of signalling cascades, such as JAK2/STAT-3 (Janus kinase 2/signal transduction activator transcription 3) PI3K (phosphoinositide 3-kinase); cross-talk between ObRb have been described previously in non-neuronal cells. Differentiated human neuroblastoma (SH-SY5Y) cells express endogenous ObR IR, respond with...
Obese patients have chronic, low-grade inflammation that predisposes to type 2 diabetes and results, in part, from dysregulated visceral white adipose tissue (WAT) functions. The specific signaling pathways underlying WAT dysregulation, however, remain unclear. Here we report the PPARgamma pathway operates differently of lean obese mice. visceral, but not subcutaneous, mice displayed increased sensitivity activation by its agonist rosiglitazone. This correlated with expression gene encoding...
Autophagy is a non-selective degradation pathway induced in energy-deprived cells and non-starved by participating cellular inflammatory responses mainly through the elimination of injured aged mitochondria that constitute an important source reactive oxygen species. We have previously reported resistin/TLR4 signaling induces inflammation insulin resistance neuronal cell. However, impact resistin-induced on autophagy unknown. In present study, we hypothesized neuroinflammation could be...
Hyperprolactinemia and hyperleptinemia occur during gestation lactation with marked hyperphagia associated leptin resistance. Prolactin (PRL) induces the expression of orexigenic neuropeptide Y (NPY) through activation JAK-2/STAT-3 signaling pathway in hypothalamic paraventricular nucleus (PVN) leading to hyperphagia. PRL may also act inhibition anorexigenic effect via induction suppressor cytokine 3 (SOCS-3). This paper aimed co-localize (PRL-R) (ObRb) receptors hypothalamus female rats...
Growing evidences suggest that obesity is associated with hypothalamic leptin resistance, leading to the alteration of food intake control. Alternative treatment using ciliary neurotrophic factor (CNTF) has been suggested because CNTF exerts a leptin-like effect, even in leptin-resistant states, but mechanisms by which maintains this effect are not yet understood. Both and act hypothalamus through similar signaling pathways including janus kinase-2/signal transducer activator transcription...
The beneficial effect of polyunsaturated omega-3 fatty acid (w-3 FA) consumption regarding cardiovascular diseases, insulin resistance and inflammation has been widely reported. Fish oil is considered as the main source commercialized w-3 FAs, other alternative sources have reported such linseed or microalgae. However, despite numerous reports, underlying mechanisms action FAs on are still not clearly established, especially those from Here, we report that Odontella aurita , a microalga rich...
Astrocytes are glial cells proposed as the main Sonic hedgehog (Shh)-responsive in adult brain. Their roles mediating Shh functions still poorly understood. In hypothalamus, astrocytes support neuronal circuits implicated regulation of energy metabolism. this study, we investigated impact genetic activation signaling on hypothalamic and characterized its effects We analyzed distribution gene transcripts pathway (Ptc, Gli1, Gli2, Gli3) using single molecule fluorescence situ hybridization...
Resistin promotes hypothalamic neuroinflammation and insulin resistance through Toll like receptor 4 (TLR4), this hormone is thought to be a link between obesity insulin-resistance. Indeed, resistin plasma levels are higher in obese resistant subjects. However, the impact of maternal on predisposition offspring unknown. Here, female mice were treated with during gestation/lactation periods, then was investigated male at p28 p90. At p28, increased expression inflammation markers (IL6, TNFα...
So far, there has been no evidence for any direct pancreatic effect of leptin in the chicken. The present study was aimed at detecting chicken receptor (cOb-R) expression isolated islets Langerhans and to examine on insulin secretion after stimulation by acetylcholine (1 µM) + glucose (14 mM) from perfused pancreas. We will show that i) full length cOb-R mRNA expressed chickens, ii) recombinant (10 nM) or diazoxide (100 rapidly (within 2 min) significantly suppressed induced without change...
Peripheral adiponectin acts on the hypothalamus to inhibit energy expenditure and increase food intake through its receptors AdipoR1 adipoR2. The hypothalamic expression of is poorly documented. We hypothesize that whether confirmed, secretion could be regulated as peripheral adiponectin. Thus, in present work, we aim determine expressed two neuronal cell lines investigate potential mechanisms regulating expression. Using immunohistochemistry, show mediobasal neurons mice. Adiponectin also...
Malnutrition in the elderly is accompanied by several metabolic dysfunctions, especially alterations energy homeostasis regulation and a loss of insulin responsiveness. Nutritional recommendations aim to enrich food with high protein supplements, composition lipid quality have been widely studied. Despite numerous studies that examined attempts overcome malnutrition through such nutritional supplementation, it still necessary study effects combination protein, lipids, vitamin D (VitD). This...