A5008906493- Neonatal Respiratory Health Research
- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- Birth, Development, and Health
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Pregnancy and preeclampsia studies
- Health, Environment, Cognitive Aging
- Heavy Metal Exposure and Toxicity
- Maternal Mental Health During Pregnancy and Postpartum
- Infant Development and Preterm Care
- Pesticide Exposure and Toxicity
- Neonatal and fetal brain pathology
- Trace Elements in Health
- Computational Drug Discovery Methods
- Congenital Diaphragmatic Hernia Studies
- Anesthesia and Neurotoxicity Research
- Urinary and Genital Oncology Studies
- Gestational Diabetes Research and Management
- Tracheal and airway disorders
- Pregnancy and Medication Impact
- Autism Spectrum Disorder Research
- Bioinformatics and Genomic Networks
- Acute Lymphoblastic Leukemia research
- Immune cells in cancer
University of North Carolina at Chapel Hill
2020-2025
North Carolina State University
2016-2021
UNC Lineberger Comprehensive Cancer Center
2021
Public Health Department
2021
Prenatal exposure to metals can influence fetal programming via DNA methylation and has been linked adverse birth outcomes long-term consequences. Epigenetic clocks estimate the biological age of a given tissue based on are potential health biomarkers. This study leveraged Extremely Low Gestational Age Newborn (ELGAN) (n = 265) evaluate associations between umbilical cord concentrations 11 as single exposures well mixtures in relation (1) placental epigenetic gestational acceleration (eGAA)...
Abstract Purpose: Improved risk stratification and predictive biomarkers of treatment response are needed for non–muscle-invasive bladder cancer (NMIBC). Here we assessed the clinical utility targeted RNA DNA molecular profiling in NMIBC. Experimental Design: Gene expression NMIBC samples was profiled by NanoString nCounter, an quantification platform, from two independent cohorts (n = 28, n 50); panel sequencing performed a subgroup 50). signatures were externally validated using datasets...
Social determinants of health (SDoH) are defined as the conditions in which people born, grow, live, work, and age. The distribution these is influenced by underlying structural factors may be linked to adverse pregnancy outcomes through epigenetic modifications gestational tissues. A promising modification age (eGA), captures 'biological' at birth. Measuring eGA placenta, an organ critical for foetal development, provide information about how SDoH 'get under skin' during influence birth...
Health outcomes among children born prematurely are known to be sexually dimorphic, with male infants often more affected, yet the mechanism behind this observation is not clear. CpG methylation levels in placenta and blood also differ by sex associated adverse health outcomes. We contrasted neonatal (n = 358) from Extremely Low Gestational Age Newborn (ELGAN) cohort based on EPIC array, which assays over 850,000 sites across epigenome. Sex-specific epigenome-wide association analyses were...
Abstract Endometrial cancer [EC] is the fourth most common in women United States. Stark racial disparities are present EC outcomes which Black have significantly higher EC-related mortality than White women. The social and biologic factors that contribute to these complex, may include differences epigenetic landscapes. To investigate race-specific tumor characteristics outcomes, we utilized recent data within Cancer Genome Atlas (TCGA). Genome-wide CpG methylation for more 850 000 sites...
Introduction Data science training has the potential to propel environmental health research efforts into territories that remain untapped and holds immense promise change our understanding of human environment. Though data resources are expanding, they still limited in terms public accessibility, user friendliness, breadth content, tangibility through real-world examples, applicability field science. Methods To fill this gap, we developed an resource, inTelligence And Machine lEarning...
ABSTRACT Background The prevalence of tetralogy Fallot (TOF), a common congenital heart defect, has increased over the last two decades. Methods Genome‐wide CpG methylation patterns were assessed and analyzed in relation to gestational air pollution exposure among 24 infants with TOF sex‐matched control without birth defect from North Carolina population‐based, case–control study major structural defects (2006–2011). Air during obstetric weeks 3–8 was assigned based on self‐reported...
Abstract Background We examined the association between placental epigenetic gestational age (eGA) acceleration and adolescent systolic blood pressure (SBP) in a cohort born extremely preterm. Methods Study participants were subset of Extremely Low Gestational Age Newborn (born <28 weeks’ gestation) who had DNA methylation quantified SBP measured during follow-up. eGA was calculated as residual from regression predicted (using Robust Placental Clock) onto chronological age. Unadjusted...
Prenatal organophosphorus pesticide (OPP) exposure has been associated with child attention-deficit/hyperactivity disorder (ADHD) in agricultural communities and those that are exposed to residentially applied insecticides. To examine this association populations primarily through diet, we estimate the associations between prenatal OPP preschool ADHD Norwegian Mother, Father Child Cohort Study (MoBa), describe modification by paraoxonase 1 (PON1) gene variants. We used participants from MoBa...
Cancer patients exhibit a broad range of inter-individual variability in response and toxicity to widely used anticancer drugs, genetic variation is major contributor this variability. To identify new genes that influence the 44 FDA-approved drug treatments treat various types cancer, we conducted high-throughput screening genome-wide association mapping using 680 lymphoblastoid cell lines from 1000 Genomes Project. The considered study represent nine classes treatment cancer addition...
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Cerebral white matter is the most common anatomic location of neonatal brain injury in preterm newborns. Factors that predispose newborns to damage are understudied. In relation studies placenta-brain-axis, dysregulated placental gene expression may play a role given its implication programming early life origins disease, including neurological disorders. There critical need investigate relationships between transcriptome and neonate. cohort extremely low gestational age (ELGANs), we aimed...
Research in environmental health is becoming increasingly reliant upon data science and computational methods that can more efficiently extract information from complex datasets. Data be leveraged to better identify relationships between exposures stressors the environment human disease outcomes, representing critical needed protect improve global public health. Still, there remains a gap surrounding training of researchers on these silico methods. We aimed address this by developing...
Background The increased risk of developing attention-deficit hyperactivity disorder (ADHD) in extremely preterm infants is well-documented. Better understanding perinatal factors, particularly those that are modifiable, can inform prevention efforts. Methods We examined data from the Extremely Low Gestational Age Newborns (ELGAN) Study. Participants were screened for ADHD at age 10 with Child Symptom Inventory-4 ( N = 734) and assessed 15 a structured diagnostic interview (MINI-KID) to...
Toxicology research has rapidly evolved, leveraging increasingly advanced technologies in high-throughput approaches to yield important information on toxicological mechanisms and health outcomes. Data produced through toxicology studies are consequently becoming larger, often producing high-dimensional data. These types of data hold promise for imparting new knowledge, yet inherently have complexities causing them be a rate-limiting element researchers, particularly those that housed “wet...
Abstract High throughput screening (HTS) programs have demonstrated that the Vitamin D receptor (VDR) is activated and/or antagonized by a wide range of structurally diverse chemicals. In this study, we examined Tox21 qHTS data set generated against VDR for reproducibility and concordance elucidated functional insights into VDR-xenobiotic interactions. Twenty-one potential agonists 19 antagonists were identified from subset >400 compounds with putative activity functionality utilizing...