A5005481333- Birth, Development, and Health
- Health disparities and outcomes
- Obesity, Physical Activity, Diet
- Epigenetics and DNA Methylation
- Health, Environment, Cognitive Aging
- Nutritional Studies and Diet
- Gestational Diabetes Research and Management
- Urban, Neighborhood, and Segregation Studies
- Food Security and Health in Diverse Populations
- Migration, Health and Trauma
- Maternal Mental Health During Pregnancy and Postpartum
- Family Support in Illness
- Racial and Ethnic Identity Research
- Air Quality and Health Impacts
- Urological Disorders and Treatments
- Cardiovascular Health and Risk Factors
- Homelessness and Social Issues
- Intergenerational Family Dynamics and Caregiving
- Environmental Justice and Health Disparities
- Pelvic floor disorders treatments
- Childhood Cancer Survivors' Quality of Life
- Heavy Metal Exposure and Toxicity
- Eating Disorders and Behaviors
- Pregnancy and preeclampsia studies
- Identity, Memory, and Therapy
University of North Carolina at Chapel Hill
2016-2025
Martin University
2024
The Centers
2023
Public Health Department
2013-2023
Duke University
2023
Center for Environmental Health
2022
University of North Carolina Health Care
2017
University of North Carolina at Charlotte
2010-2011
Université Paris Cité
2006
Abstract Coronavirus disease 2019 (COVID-19) is disproportionately burdening racial and ethnic minority groups in the United States. Higher risks of infection mortality among racialized minorities are a consequence structural racism, reflected specific policies that date back centuries persist today. Yet our surveillance activities do not reflect what we know about how racism structures risk. When measuring disparities deaths due to COVID-19, Centers for Disease Control Prevention...
Understanding whether racial and ethnic inequities exist along the postpartum mental health care continuum is vital because inequitable identification of depression can lead to referral receipt care. We aimed expand on existing cross-sectional single-state data documenting potential disparities in Using early (from two six months) late twelve fourteen survey from seven US jurisdictions, we documented patterns depressive symptoms, perinatal mood anxiety disorder (PMAD) diagnosis, overall by...
Importance Epigenetic clocks represent molecular evidence of disease risk and aging processes have been used to identify how social lifestyle characteristics are associated with accelerated biological aging. However, most research is based on samples older adults who already measurable chronic disease. Objective To investigate whether sociodemographic in a younger adult sample across wide array epigenetic clock measures. Design, Setting, Participants This cohort study was conducted using...
Pre-pregnancy obesity is an established risk factor for adverse sex-specific cardiometabolic health in offspring. Epigenetic alterations, such as DNA methylation (DNAm), are a hypothesized link; however, epigenomic targets remain unclear. Leveraging data from the Newborn Epigenetics Study (NEST) cohort, linear regression models were used to identify CpG sites cord blood leukocytes associated with pre-pregnancy 187 mother-female and 173 mother-male offsprings. DNAm was measured using Illumina...
Abstract Background Neighborhood characteristics are robust predictors of overall health and mortality risk for residents. Though there has been some investigation the role that molecular indicators may play in mediating neighborhood exposures, little effort to incorporate newly developed epigenetic biomarkers into our understanding outcomes. Methods Using 157 participants Detroit Health Study with detailed assessments genome-wide DNA methylation profiling via Illumina 450K array, we...
Living in adverse neighborhood environments has been linked to risk of aging-related diseases and mortality; however, the biological mechanisms explaining this observation remain poorly understood. DNA methylation (DNAm), a proposed mechanism biomarker aging responsive environmental stressors, offers promising insight into potential molecular pathways. We examined associations between three social environment measures (poverty, quality, cohesion) epigenetic clocks (Horvath, Hannum, PhenoAge)...
Background: Organophosphate esters (OPEs) are ubiquitous chemicals, used as flame retardants and plasticizers. OPE usage has increased over time a substitute for other controlled compounds. This study investigates the impact of prenatal exposure on executive function (EF) in preschoolers. Methods: We selected 340 preschoolers from Norwegian Mother, Father, Child Cohort Study. Diphenyl-phosphate (DPhP), di-n-butyl-phosphate (DnBP), bis(2-butoxyethyl) phosphate (BBOEP),...
Importance The link between familial loss of a loved one and long-term health decline is complex not fully understood. Objective To test associations losing parent, sibling, child, or partner spouse with accelerated biological aging. Design, Setting, Participants Data from the National Longitudinal Study Adolescent to Adult Health, US population-based longitudinal cohort study, were analyzed. enrolled 1994 1995 for wave 1, while in grades 7 12, followed up through 5 2018. study analyzed...
Abstract Importance Epigenetic clocks represent molecular evidence of disease risk and aging processes have been used to identify how social lifestyle characteristics are associated with accelerated biological aging. However, most this research is based on older adult samples who already measurable chronic disease. Objective To investigate whether sociodemographic related in a younger sample across wide array epigenetic clock measures. Design Nationally representative prospective cohort...
Low-income Hispanic women experience elevated rates of high postpartum weight retention (PPWR), which is an independent risk factor for lifetime obesity. Sociocultural factors might play important role among women; however, very few studies have examined this association.
Abstract Background Police-reported crime data (hereafter “crime”) is routinely used as a psychosocial stressor in public health research, yet few studies have jointly examined (a) differences exposure based on participant race and ethnicity, (b) measures of exposure, (c) considerations for how to police captured police-recorded data. We estimate neighborhood discuss the implications structural ethnicity. Methods Using GPS coordinates from 1188 participants Newborn Epigenetics Study, we...
Social determinants of health (SDoH) are defined as the conditions in which people born, grow, live, work, and age. The distribution these is influenced by underlying structural factors may be linked to adverse pregnancy outcomes through epigenetic modifications gestational tissues. A promising modification age (eGA), captures 'biological' at birth. Measuring eGA placenta, an organ critical for foetal development, provide information about how SDoH 'get under skin' during influence birth...
Abstract Structural racism has likely shaped the geographic distribution and resource allocation of rural populations marginalized racial/ethnic groups. We sought to 1) quantify disparities in severe maternal morbidity (SMM) distributions resources by race racial composition county, 2) determine whether a hypothetical intervention on would reduce SMM, using linked birth certificates claims from Medicaid beneficiaries giving 2014-2019 North Carolina (61 counties, 77,665 births). used ratio...
Aging of the immune system is characterized by changes in T-cell compartment, including a decrease naïve T-cells and an increase memory T-cells. Stress exposures are known to predict accelerated aging older adults. However, social relationships, which often linked stress mechanisms, have not been widely studied relation these adaptive biomarkers, particularly younger populations. We examined associations between terms quantity (Social Network Index, Close Contacts Index) quality...
Abstract: Background: Hypertensive complications during pregnancy occur in nearly 8 percent of pregnancies and account for 15 all maternal mortalities the United States. The purpose this study was to investigate further association between physical activity hypertensive using data from a population‐based surveillance system. Methods: This included 3,348 participants 2004 2006 North Carolina Pregnancy Risk Assessment Monitoring System. were assessed birth certificate data, levels before...