A5088271731- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Barrier Structure and Function Studies
- Genomics and Chromatin Dynamics
- MicroRNA in disease regulation
- RNA modifications and cancer
- Ovarian cancer diagnosis and treatment
- COVID-19 Clinical Research Studies
- Nuclear Structure and Function
- PARP inhibition in cancer therapy
- RNA Research and Splicing
- Neurological Disease Mechanisms and Treatments
- Natural Antidiabetic Agents Studies
- Cancer Genomics and Diagnostics
- Diabetes and associated disorders
- Surgical Sutures and Adhesives
- Metabolism, Diabetes, and Cancer
- NF-κB Signaling Pathways
- T-cell and B-cell Immunology
- Reproductive System and Pregnancy
- Oil and Gas Production Techniques
- Surgical site infection prevention
- vaccines and immunoinformatics approaches
All India Institute of Medical Sciences
2012-2025
Cancer Institute (WIA)
2024
All India Institute of Medical Sciences Raipur
2024
All India Institute of Medical Sciences Bhopal
2024
Desh Bhagat Ayurvedic College and Hospital
2024
Siriraj Hospital
2023
Mahidol University
2023
Al-Azhar University
2023
Farwaniya Hospital
2023
Ministry of Health
2023
<h3>Objective</h3> Claudin-1 expression is increased and dysregulated in colorectal cancer causally associates with the dedifferentiation of colonic epithelial cells, progression metastasis. Here, we have sought to determine role claudin-1 plays regulation intestinal homeostasis. <h3>Design</h3> We used a novel villin-claudin-1 transgenic (Cl-1Tg) mouse as model (with overexpression). The effect upon differentiation, lineage commitment Notch-signalling was determined using...
Tight junctions are the apical cell-cell adhesion that regulate paracellular permeability and critical for epithelial cell polarity. Molecular architecture of tight junction has been studied extensively, which confirmed claudin family proteins is integral component junction. Loss central to cellular transformation acquisition metastatic potential; however, role play in a series pathophysiological events, including human carcinoma development, only now beginning be understood. Several mouse...
Naringin, a bioflavonoid isolated from grapefruit, is well known to possess lipid-lowering and insulin-like properties. Therefore, we assessed whether naringin treatment ameliorates insulin resistance (IR), β-cell dysfunction, hepatic steatosis kidney damage in high-fat diet (HFD)–streptozotocin (STZ)-induced type 2 diabetic rats. Wistar albino male rats were fed HFD (55 % energy fat cholesterol) develop IR on the 10th day injected with low dose of streptozotocin (40 mg/kg, intraperitoneal...
OBJECTIVE Assessment of the predictive power The Environmental Determinants Diabetes in Young (TEDDY)-identified risk factors for islet autoimmunity (IA), type autoantibody appearing first, and 1 diabetes (T1D). RESEARCH DESIGN AND METHODS A total 7,777 children were followed from birth to a median 9.1 years age development autoantibodies progression T1D. Time-dependent sensitivity, specificity, receiver operating characteristic (ROC) curves calculated provide estimates their individual...
Abstract In recent times Gallbladder cancer (GBC) incidences increased many folds in India and are being reported from arsenic hotspots identified Bihar. The study aims to establish association between exposure gallbladder carcinogenesis. the present study, n = 200 were control volunteers 152 confirmed cases. studied GBC patient’s biological samples-gallbladder tissue, stone, bile, blood hair samples collected for estimation. Moreover, 512 patients also evaluated presence of understand level...
The most important regulator of insulin gene expression in pancreatic beta- cells is glucose, which affects transcription, mRNA translation, and secretion. Insulin transcription both positively negatively regulated by glucose. Recently, we have shown that the inhibition caused passaging HIT T-15 beta-cells, presence high was due, part, to reduced a key enhancer-mediated expression, somatostatin factor-1 (STF-1). In this study, examined whether activity other essential regulators RIPE3b1...
Background: Subclinical hypothyroidism, a thyroid disorder without obvious symptoms of deficiency, occurs in 3%–8% the global population. Ashwagandha [Withania somnifera (L.) Dunal], traditional medicine Ayurveda, is often prescribed for dysfunctions. Objective: This pilot study was designed to evaluate efficacy and safety ashwagandha root extract subclinical hypothyroid patients. Design, Setting, Participants: A prospective, randomized, double-blind, single-center placebo-controlled...
Understanding the causes of diverse outcome COVID-19 pandemic in different geographical locations is important for worldwide vaccine implementation and control responses. We analyzed 42 unexposed healthy donors 28 mild subjects up to 5 months from recovery SARS-CoV-2 specific immunological memory. Using HLA class II predicted peptide megapools, we identified cross-reactive CD4+ T cells around 66% individuals. Moreover, found detectable immune memory patients several after crucial arms...
Denial of the appropriate cell-matrix interaction in epithelial cells induces apoptosis and is called 'anoikis'. Cancer are resistant to anoikis it believed that resistance helps promote tumor malignancy especially metastasis. We others have demonstrated expression tight junction protein claudin-1 highly upregulated colorectal cancer (CRC) progression However, molecular mechanism/s underlying claudin-1-dependent regulation CRC remains poorly understood. In current study, we determined...
Dysregulation of tight junctions (TJs) is often associated with human diseases including carcinogenesis and recent studies support role TJ integral proteins in the regulation Epithelial-to-Mesenchymal Transition (EMT). In this regard, expression claudin-1, a key constituent TJs, highly increased colon cancer causally tumor growth progression. However, mechanism/s underlying claudin-1 intestinal epithelial cells remains poorly understood. our studies, we have identified putative binding sites...
The global epidemic of type 2 diabetes demands the rapid evaluation new and accessible interventions. This study investigated whether Aegle marmelos fruit aqueous extract (AMF; 250, 500 1000 mg/kg) improves insulin resistance, dyslipidemia β‐cell dysfunction in high fat diet fed‐streptozotocin (HFD‐STZ)‐induced diabetic rats by modulating peroxisome proliferator‐activated receptor‐γ (PPARγ) expression. serum levels glucose, insulin, homeostasis model assessment resistance (HOMA‐IR), function...
MAGEA11 is a cancer germline (CG) antigen and androgen receptor co-activator. Its expression in cancers other than prostate, its mechanism of activation, has not been reported. In silico analyses reveal that frequently expressed human cancers, increased during tumor progression, correlates with poor prognosis survival. prostate epithelial ovarian (EOC), was associated promoter global DNA hypomethylation, activation CG genes. Pharmacological or genetic inhibition methyltransferases (DNMTs)...
Solid tumors are covered by stroma, which is hypoxic in nature and composed of various non‐malignant components such as endothelial cells, fibroblasts, pericytes that support tumor growth. Tumor stroma represents a mechanical barrier for infiltration CD8+ effector T cells particular. In this context, our previous studies have demonstrated the therapeutic impact Low‐Dose Radiation (LDR)‐primed M1‐retuned (iNOS+) peritumoral macrophages produce inducible nitric oxide, immunological roles on...
Head and neck cancer care was analysed in 2167 unselected patients for management compliance outcome. Median age 55 years, with a male to female ratio of 5.5[ratio ]1. Major sites were oropharynx (32.4 per cent), larynx (19.8 oral (16.6 cent) hypopharynx (12.9 cent). Stage-wise distribution I–II=8.9 cent, III=20.6 cent IV=60.3 unstaged=10.2 cent. Squamous cell carcinoma the dominant histology 90.9 Clinic-based cancer-directed treatment decisions made 1905 patients: curative intent 53...
High mobility group B (HMGB) chromosomal proteins, which plays important role in cancer and inflammation, were followed at various stages of the squamous cell carcinoma skin. Present results analyzed by histopathology, BrdU assay, immunohistochemistry, western blot RT-PCR, indicate that early tumorigenesis, expression HMGB (B1, B2), raised only about 20%. However, advanced (⩾12 weeks) tumors showed significant (⩾80%) increase HMG levels. Using skin model, we demonstrated high levels directly...