The chemical composition and the antibacterial activity of essential oils obtained by hydrodistillation from leaves Callistemon citrinus viminalis were analyzed GC GC/MS. Twenty-four twelve components identified for C. viminalis, representing 92.0% 98.3% total oils. major 1,8-cineole (61.2% 83.2%) α-pinene (13.4% 6.4%), respectively. in vitro was studied against 12 bacteria strains using disc diffusion broth microdilution methods. exhibited strong zone inhibitions some such as S. faecalis...

Elevated uric acid level, an index of gout resulting from the over-activity xanthine oxidase (XO), increases risk developing hypertension. However, research has shown that plant-derived inhibitors XO and angiotensin 1-converting enzyme (ACE), two enzymes implicated in hypertension, respectively, can prevent or ameliorate both diseases, without noticeable side effects. Hence, this study characterized polyphenolics composition guava leaves extract evaluated its inhibitory effect on ACE...

A crude methanol extract of the root plant Moringa oleifera Lam. was screened for anti inflammatory effect using rat paw edema and 6-day air pouch models. Following oral administration, inhibited carrageenan-induced in a dose-dependent manner, with 50% inhibitory concentration - IC 50 (dose producing inhibition) 660 mg/kg. On acute inflammation induced carrageenan, much more potent, values 302.0 mg/kg 315.5 mg/kg, inhibition cellular accumulation fluid exudation, respectively. Maximum...

Ficus species are used in African traditional medicine the treatment of a wide variety ailments and diseases such as convulsive disorder, wound healing, gonorrhea, tuberculosis, diabetes, diarrhoeal infections, dysentery, malaria HIV. The aim this study was to isolate phytochemical constituents plant test them for their antibacterial activity.The fruits, leaves stem bark were extracted with organic solvents compounds extracts separated purified by column chromatography before being...

Previous studies from our laboratories indicate that the anti-diabetic effects of Syzygium cordatum (Hochst.) [Myrtaceae] leaf extract in streptozotocin-induced diabetic rats may be attributed part to mixtures triterpenes, oleanolic acid (3ß-hydroxy-olea-12-en-28-oic acid, OA) and ursolic (3ß –hydroxyl-urs-12-en-28-oic UA). For bioactive compounds have potential diabetes management, they should alleviate or prevent complications mellitus, kidney function, cardiovascular disorders. This study...

Mimusops caffra E. Mey. ex A.DC and obtusifolia Lam (both members of the Sapotaceae family), Hypoxis colchicifolia Bak (family Hypoxidaceae) are used by traditional healers in Zululand to manage malaria. Anti-plasmodial investigation crude extracts some triterpenes isolated from plants showed activity against a chloroquine sensitive (CQS) strain Plasmodium falciparum (D10). Among leaves M. exhibited highest activity, with an IC₅₀ 2.14 μg/mL. The pentacyclic tritepenoid ursolic acid (1), was...

The outbreak of Coronavirus infection (COVID-19) has prompted the World Health Organisation (WHO) to declare outbreak, a Public Emergency International concern. As part efforts discover lead compounds for clinical use, 53 molecules were screened using molecular docking and dynamic simulations (MDS) techniques identify potential inhibitors SARS-CoV-2 spike protein (COVID-19 Sgp) main protease Mpro) or both. Lopinavir (LPV), nelfinavir (NEF), hydroxychloroquine (HCQ), remdesivir (RDV) an...

Amino acid analysis showed that solvent extracts of Cajanus cajan L. Millsp. (Fabaceae) seeds (white species) contain, as free amino acid, much 26.3% phenylalanine. Antisickling experiments based on the estimated amount phenylalanine in methanol (water-soluble) extract presence this alone could account for about 70% antisickling potency seed extract.

Malaria continues to be a global burden as the efficacy of most commercial anti-malarial drugs has been compromised by evolution parasite resistance. With urgent need created for development alternative and more efficient drugs, this study focused on evaluation agents Warburgia salutaris stem bark.The bark was extracted with dichloromethane followed silica gel column chromatography that led isolation iso-mukaadial acetate, drimanoid sesquiterpene. This compound characterized spectroscopic...

The involvement of cellular oxidative stress in antibacterial therapy has remained a topical issue over the years. In this study, contribution to astaxanthin‐mediated bacterial lethality was evaluated silico and vitro . For analysis, minimum inhibitory concentration (MIC) astaxanthin lower than that novobiocin against Staphylococcus aureus but generally higher those reference antibiotics other test organisms. level superoxide anion tested organisms increased significantly following treatment...

Boiled and crude ethanolic extracts of edible CAJANUS CAJAN beans were prepared used for IN VITRO studies involving 14 individual blood samples obtained from confirmed sickle cell (HbSS) patients. It was demonstrated that the able not only to inhibit sickling in sodium metabisulphite solution, but also quickly reverted normal morphology, already sickled erythrocytes. There a noticeable improvement general morphology erythrocytes after coming into contact with plant extracts.

Diabetes mellitus (DM) is a chronic metabolic disorder which has become major risk to the health of humankind, as its global prevalence increasing rapidly. Currently available treatment options in modern medicine have several adverse effects. Thus, there an urgent need develop alternative cost-effective, safe, and active treatments for diabetes. In this regard, medicinal plants provide best option new therapeutic remedies desired be effective safe. Recently, we focused our attention on...

Abstract This study utilized a comprehensive computational approach to identify multi-targeted drug molecules against prominent SARS-CoV-2 druggable proteins. is considered imperative as the damaging effects of virus still lingers global threat and because increasing awareness enhanced therapeutic efficacy multi-target drug. Thus, we investigated identified novel interventions for from an array previously reported natural antiviral compounds. The systematic virtual screening was achieved by...

Lippia javanica (Burm. f.) is an African plant with numerous ethnomedicinal uses, including asthma, tuberculosis, colds, influenza, pneumonia, coughs, and dermatitis treatments. Many of the properties folkloric claims about have since established by scientific studies. In this context, we conducted bibliometric systematic analyses literature on phytochemistry pharmacology L. special focus plant’s bioactive metabolites. Bibliometric data – using Web Science Scopus databases revealed that most...

Buddleja saligna (family Buddlejaceae) is a medicinal plant endemic to South Africa. Two isomeric pentacyclic triterpenes, oleanolic acid and ursolic acid, were isolated from the leaves of B. using silica gel column chromatography. Compounds subjected derivatization with acetic anhydride in presence pyridine obtain acid-3-acetate acid-3-acetate, respectively. The structures these compounds fully characterized by detailed nuclear magnetic resonance (NMR) investigations, which included 1H 13C...