A5086073592- Sexual function and dysfunction studies
- Hormonal and reproductive studies
- Urinary Bladder and Prostate Research
- Ferroptosis and cancer prognosis
- Pelvic floor disorders treatments
- Aldose Reductase and Taurine
- Renal cell carcinoma treatment
- COVID-19 and healthcare impacts
- RNA Research and Splicing
- RNA modifications and cancer
- Tissue Engineering and Regenerative Medicine
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Hormonal Regulation and Hypertension
- Diabetes Treatment and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer-related Molecular Pathways
- Sexuality, Behavior, and Technology
- Cancer-related molecular mechanisms research
- Menopause: Health Impacts and Treatments
- Genital Health and Disease
- Apelin-related biomedical research
- Pain Mechanisms and Treatments
- Cancer, Lipids, and Metabolism
- Urological Disorders and Treatments
- Pharmacology and Obesity Treatment
Anhui Medical University
2025
Anhui Provincial Hospital
2025
Zhejiang Hisun Pharmaceutical (China)
2024
Tongji Hospital
2016-2023
Huazhong University of Science and Technology
2016-2023
Stanford University
2002-2020
University of California, San Francisco
2017-2020
Urology San Antonio
2018
Huazhong University of Science and Technology Hospital
2016
Tongji University
1996
The coronavirus disease 2019 (COVID-19) has been spreading all over the world since December 2019. However, medical information regarding urogenital involvement in recovered COVID-19 patients is limited or unknown.To comprehensively evaluate patients.Men aged between 20 years and 50 who were diagnosed with SARS-CoV-2 infection when study was conducted enrolled our study. Demographic clinical characteristics, history of hospitalization collected analyzed. Urine, expressed prostatic secretions...
The coronavirus disease 2019 (COVID-19) has spread worldwide with alarming levels of and severity. distribution angiotensin converting enzyme 2 (ACE2) transmembrane protease serine (TMPRSS2) from bioinformatics evidence, the autopsy report for COVID-19 published study on sperm quality indicated could have a negative impact male fertility. However, whether fertility is persistent remains unknown, which requires long-term follow-up investigation.Semen samples were collected 36 patients median...
To investigate the therapeutic potential of dimethyl fumarate (DMF) in improving erectile function bilateral cavernous nerve injury (BCNI) rats, along with elucidating its underlying mechanisms.
Low-intensity extracorporeal shock wave therapy (Li-ESWT) is used in the treatment of erectile dysfunction, but its mechanisms are not well understood. Previously, we found that Li-ESWT increased expression brain-derived neurotrophic factor (BDNF). Here assessed underlying signaling pathways Schwann cells vitro and penis tissue vivo after nerve injury. The result indicated BDNF were significantly by injury, as (SCs, RT4-D6P2T) vitro. activated protein kinase RNA-like endoplasmic reticulum...
Abstract Erectile dysfunction (ED) is a major health issue among men with diabetes, and ED induced by diabetes mellitus (DMED) particularly difficult to treat. Therefore, novel therapeutic approaches for the treatment of DMED are urgently needed. Exosomes, nanosized particles involved in many physiological pathological processes, may become promising tool treatment. In this study, we investigated effect exosomes derived from corpus cavernosum smooth muscle cells (CCSMC‐EXOs) on erectile...
The population with diabetes mellitus-induced erectile dysfunction is increasing rapidly, but current drugs are not effective in treating dysfunction. Studies of the traditional Chinese medicine extract berberine on and its complications provide us new ideas.To evaluate therapeutic effect potential mechanism function diabetic rats.Fifty male Sprague-Dawley rats were randomly grouped, 42 injected intraperitoneally streptozotocin to establish a model. Erectile screened out through apomorphine...
Mitochondria not only are the main source of ATP synthesis but also regulate cellular redox balance and calcium homeostasis. Its dysfunction can lead to a variety diseases promote cancer metastasis. In this study, we aimed explore molecular characteristics prognostic significance mitochondrial genes (MTGs) related oxidative stress in clear cell renal carcinoma (ccRCC). A total 75 differentially expressed MTGs were analyzed from The Cancer Genome Atlas (TCGA) database, including 46...
Aim Stress urinary incontinence (SUI) is a significant health problem for women. Treatments employing muscle derived stem cells (MDSCs) may be promising approach to this prevalent, bothersome condition, but these treatments are invasive and require collection of from one site injection into another. It also unknown whether or not establish themselves function as in the target tissues. Alternatively, low‐intensity extracorporeal shock wave therapy (Li‐ESWT) non‐invasive has shown positive...
The imbalance of the redox system has been shown to be closely related occurrence and progression many cancers. However, biological function clinical significance redox‐related genes (RRGs) in clear cell renal carcinoma (ccRCC) are unclear. In our current study, we downloaded transcriptome data from Cancer Genome Atlas (TCGA) database ccRCC patients identified differential expression RRGs tumor normal kidney tissues. Then, a total 344 differentially expressed RRGs, including 234 upregulated...
Post-transcriptional regulation plays a leading role in gene and RNA binding proteins (RBPs) are the most important posttranscriptional regulatory protein. RBPs had been found to be abnormally expressed variety of tumors is closely related its occurrence progression. However, exact mechanism bladder cancer (BC) unknown. We downloaded transcriptomic data BC from Cancer Genome Atlas (TCGA) database used bioinformatics techniques for subsequent analysis. A total 116 differentially were...
Midbrain astrocyte-derived neurotrophic factor (MANF) is a secreted protein induced by endoplasmic reticulum stress. Previous studies have indicated that intravenous administration of 1 mg/kg/day recombinant human MANF with His tag (His-MANF) for 3 days can ameliorate acute ulcerative colitis in mice. However, long-term therapy has many disadvantages. In this paper, His-MANF was successfully encapsulated into alginate and hyaluronic acid hybrid hydrogel microcapsules one step using the gas...
Objectives To evaluate the therapeutic effect of once‐weekly low‐intensity extracorporeal shock wave therapy (Li‐ ESWT ) on underactive bladder ( UAB in streptozotocin STZ )‐induced diabetic rat model. Materials and Methods In all, 36 female Sprague–Dawley rats were divided into three groups: normal control NC ), diabetes mellitus DMC DM with Li‐ ). The two groups received an intraperitoneal 60 mg/kg injection to induce . was applied toward pelvis starting 4 weeks after administration...
Diabetes mellitus (DM) induces impairment of male reproductive system and is considered as a key factor that could partially provide an explanation for infertility. Thus, understanding the mechanism underlying DM-induced infertility will aid in identification novel therapeutic stratagems.To delineate role ROS/JAK2/NFκB pathway low function impaired spermatogenesis. Additionally, to investigate protective effect monomeric Berberine (BB) inhibits pathway, pathogenesis infertility.12-week-old...
The psychological and sexual health of different populations are negatively affected during the coronavirus disease 2019 (COVID-19) pandemic. However, little is known about distress erectile function male recovered patients with COVID-19 in long term.We aimed to evaluate mid-to-long terms.We recruited 67 eligible followed them up twice within approximately 6 months recovery time. were assessed by validated Chinese version paper questionnaires.The primary outcomes Symptom Checklist 90...
To investigate the protective effects and mechanisms of human tissue kallikrein 1 (hKLK1) on type diabetes mellitus- (DM-) induced erectile dysfunction in rats. Materials Methods. The homozygous transgenic rats (TGR) harboring hKLK1 gene age-matched wild-type Sprague Dawley (WTR) were involved, intraperitoneal injection streptozotocin was utilized to induce Forty-eight-week-old male randomly divided into a WTR group, TGR diabetic group (WTDM), (TGDM), TGDM with HOE140 (TGDMH), eight each...
Erectile dysfunction (ED) caused by pelvic neurovascular injury (PNVI) is often refractory to treatment. In many cases, erectogenic therapy administered in a delayed fashion.To evaluate penile hemodynamic effects and histologic changes associated with low-intensity extracorporeal shock wave (Li-ESWT) after PNVI ED rat model. We visualized images using immunofluorescence 3-dimensional imaging of solvent-cleared organs (3DISCO), novel technique.A total 32 Sprague-Dawley male rats aged 12 weeks...
To determine whether microRNA could be a therapy target of erectile dysfunction (ED) and the underlying mechanisms.Eight-week-old fasting male SD rats were intraperitoneally injected with streptozotocin to construct diabetic rat models. Diabetic ED treated miRNA-92a inhibitor. The cavernous nerves electrically stimulated measure intracavernous pressure mean arterial in each group. After detection, penile tissues are properly stored for subsequent experiments. Rat aortic endothelial cells...
Abstract Background Neurogenic erectile dysfunction (NED) caused by cavernous nerve (CN) injury is a typical complication after pelvic surgery, which lacks efficient treatments. Acetyl‐L‐carnitine (ALCAR) has been proven to promote repair. Objectives To investigate the effect and potential mechanism of ALCAR in treatment NED. Materials methods Thirty‐two rats were randomly divided into bilateral CN (BCNI) group, BCNI + lower‐dose (50 mg/kg/day) higher‐dose (100 sham‐operated group. Erectile...