A5100760732- Mycobacterium research and diagnosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Tuberculosis Research and Epidemiology
- Pharmacological Effects of Natural Compounds
- Ginseng Biological Effects and Applications
- Ultrasound and Hyperthermia Applications
- Cancer Mechanisms and Therapy
- Ubiquitin and proteasome pathways
- Ultrasound Imaging and Elastography
- Radiomics and Machine Learning in Medical Imaging
- Liver Disease and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Quinazolinone synthesis and applications
- Peptidase Inhibition and Analysis
- Microbial Inactivation Methods
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- Protein Hydrolysis and Bioactive Peptides
- Reproductive Biology and Fertility
- Traditional Chinese Medicine Analysis
- Pancreatic and Hepatic Oncology Research
- HIV Research and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Protein Degradation and Inhibitors
The First Affiliated Hospital, Sun Yat-sen University
2014-2025
Sun Yat-sen University
2014-2025
Southern Illinois University School of Medicine
2025
Capital Medical University
2009-2025
Inner Mongolia Medical University
2013-2024
Bridge University
2023
James J. Peters VA Medical Center
2007-2021
Thomas Jefferson University
2019-2021
Wannan Medical College
2020
Inner Mongolia University of Science and Technology
2019
Supramolecular nanoparticles for photothermal therapy (PTT) have shown promising therapeutic efficacy in the primary tumor and great potential turning whole-body immune microenvironment from "cold" to "hot," which allows simultaneous treatment of metastatic site. In this work, we develop a liposome-based PTT nanoparticle through self-assembly FDA-approved intravenous injectable lipids agent, indocyanine green (ICG). The obtained ICG-liposome shows long-term storage stability, high ICG...
We aimed to evaluate the performance of a deep learning (DL)-based Radiomics strategy designed for analyzing contrast-enhanced ultrasound (CEUS) not only predict progression-free survival (PFS) radiofrequency ablation (RFA) and surgical resection (SR) but also optimize treatment selection between them patients with very-early or early-stage hepatocellular carcinoma (HCC).We retrospectively enrolled 419 examined by CEUS within 1 week before receiving RFA SR (RFA: 214, SR: 205) from January...
Abstract p53 acetylation is indispensable for its transcriptional activity and tumor suppressive function. However, the identity of reader protein(s) remains elusive. PBRM1 , second most highly mutated suppressor gene in kidney cancer, encodes PBRM1. Here, we identify as a on lysine 382 (K382Ac) through bromodomain 4 (BD4). Notably, mutations key residues BD4 disrupt recognition K382Ac. The mutation also reduces binding to promoters target genes such CDKN1A (p21). Consequently, mutant fails...
Colorectal cancer (CRC) is a significant global health burden, with high morbidity and mortality rates. It often diagnosed at middle to advanced stage, affecting approximately 35% of patients the time diagnosis. Currently, chemotherapy has been used improve patient prognosis increase overall survival. However, can also have cytotoxic effects lead adverse reactions, such as inhibiting bone marrow hematopoiesis, causing digestive dysfunction, hand-foot syndrome, even life-threatening...
Introduction: The anti-cancer potency of copper-doped carbon quantum dots (Cu-CDs) against breast cancer progression needs more detailed investigations. Methods: With urea and ethylene glycol applied as sources copper sulfate used a reactive dopant, Cu-CDs were synthesized in the current study by one-step hydrothermal synthesis method, followed characterization biocompatibility evaluations Cu-CDs. Subsequently, was confirmed these biochemical, molecular, transcriptomic assessments, including...
A key feature of the pathogenesis human immunodeficiency virus type 1 (HIV-1) infection is gradual loss CD4-positive T cells. number gene therapy strategies have been designed with intent inhibiting HIV replication in mature As cells are products hematolymphoid differentiation, insertion antiviral genes into hematopoietic stem could serve as a vehicle to confer long-term protection progeny derived from transduced One such "cellular immunization" strategy utilizes coding for HIV-1 rev...
A great challenge of cancer chemotherapy is to eliminate cells and concurrently maintain the quality life (QOL) for patients. Previously, we identified a novel anti-cancer bioactive peptide (ACBP), induced in goat spleen or liver following immunization with human gastric protein extract. ACBP alone exhibited anti-tumor activity without measurable side effects. Thus, hypothesize that combined could improve efficacy treatment lead better QOL. In this study, was isolated purified from immunized...
Clinical improvement in inflammatory bowel disease (IBD) treated with methotrexate and 6-mercaptopurine (6-MP) is associated a decrease pro-inflammatory cytokines. This has been presumed to indicate the mechanism of action 6-MP. Although controversial, there are increasingly compelling data that Mycobacterium avium subspecies paratuberculosis (MAP) may be an etiological agent some or all IBD. We hypothesized clinical efficacy 6-MP IBD simply inhibit growth MAP.The effect on MAP kinetics by...
Abstract The success of transcriptome-wide association studies (TWAS) has led to substantial research toward improving the predictive accuracy its core component genetically regulated expression (GReX). GReX links information with genotype and phenotype by playing two roles simultaneously: it acts as both outcome genotype-based models (for predicting expressions) linear combination genotypes (as predicted for tests. From perspective machine learning (considering SNPs features), these are...
In the present study, synergistic protective effect of co-supplementation glutathione (GSH) with selenium nanoparticles (SeNPs) on cryopreservation efficiency bull semen was analyzed.After collection, ejaculates Holstein bulls were subsequently diluted a Tris extender buffer supplemented different concentrations SeNPs (0, 1, 2, and 4 μg/ml), followed by equilibration at 4°C assessment sperm viability motility. Subsequently, pooled, split into four equal groups, basic (negative control group,...
Introduced in 1942, sulfasalazine (a conjugate of 5-aminosalicylic acid (5-ASA) and sulfapyridine) is the most prescribed medication used to treat "inflammatory" bowel disease (IBD.) Although controversial, there are increasingly compelling data that Mycobacterium avium subspecies paratuberculosis (MAP) may be an etiological agent some or all IBD. We have shown two other agents therapy IBD (methotrexate 6-MP) profoundly inhibit MAP growth. concluded their plausible mechanism action as...
The role of vitamins in the combat disease is usually conceptualized as acting by modulating immune response an infected, eukaryotic host. We hypothesized that some may directly influence growth prokaryotes, particularly mycobacteria.The effect four fat-soluble was studied radiometric Bactec® culture. were A (including a precursor and three metabolites,) D, E K. evaluated eight strains mycobacterial species (four M. avium subspecies paratuberculosis (MAP), two tb. complex).Vitamins D cause...
Regardless of the essential role copper (Cu) in physiological regulation process mammalian reproduction, excessive exposure to Cu triggers meiotic defects porcine oocytes via compromising mitochondrial functions. However, connections between and ovine have not been reported. In this study, effect sulfate (CuSO4) on potentials was analyzed. Subsequently, ameliorative glutathione (GSH) supplementation CuSO4 exposed investigated. For these purposes, vitro maturation (IVM) cumulus oocyte...
Mycobacterium avium subspecies paratuberculosis (MAP) may be zoonotic. Recently the "immuno-modulators" methotrexate, azathioprine and 6-MP "anti-inflammatory" 5-ASA have been shown to inhibit MAP growth in vitro. We concluded that their most plausible mechanism of action is as antiMAP antibiotics. The "immunosuppressants" Cyclosporine A, Rapamycin Tacrolimus (FK 506) treat a variety "autoimmune" "inflammatory" diseases. are macrolides. hypothesized mode simply growth.The effect on...
<title>Abstract</title> Background To investigate factors associated with liver regeneration capacity in patients hepatocellular carcinoma (HCC) after resection. Methods A total of 123 HCC who underwent stiffness (LS) measurement by two-dimensional shear wave elastography (2D-SWE) before resection were retrospectively included. The future remnant (FLR) and postoperative volume (PLV) measured. standardized (sFLR), parenchymal hepatic rate (PHRR), index (RI) calculated. Patients classified...
Introduction: There is an urgent need for targeted therapies in metastatic melanoma patients with NRAS mutations, who comprise more than 25% of this population. This study investigates the therapeutic potential targeting Ubiquitin-Specific Peptidase 7 (USP7) a highly selective inhibitor, FT671, mutant melanoma. In addition, synergistic effects combination FT671 MEK1/2 inhibitor (MEKi) on pyroptosis induction, tumor suppression and immune activation were evaluated. Moreover, potency triple...