A5100729592- Cancer Mechanisms and Therapy
- Ubiquitin and proteasome pathways
- Pancreatic and Hepatic Oncology Research
- Liver physiology and pathology
- Autophagy in Disease and Therapy
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Sirtuins and Resveratrol in Medicine
- Ferroptosis and cancer prognosis
- Nutrition and Health in Aging
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Histone Deacetylase Inhibitors Research
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Immunotherapy and Biomarkers
- Enhanced Recovery After Surgery
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- Kruppel-like factors research
- Cannabis and Cannabinoid Research
- Gastric Cancer Management and Outcomes
- Immunotherapy and Immune Responses
- Bone Metabolism and Diseases
Affiliated Hospital of Nantong University
2010-2024
Nantong University
2008-2024
Hubei University of Medicine
2024
Shenzhen Pingle Orthopedic Hospital
2023
Soochow University
2020-2021
First Affiliated Hospital of Soochow University
2020-2021
Guilin Medical University
2019
National Institute on Deafness and Other Communication Disorders
2014-2017
Hainan Normal University
2017
Harbin Medical University
2015
Abstract Background and Objective Octamer‐4 (Oct4), a transcription factor involved in regulating human embryonic stem cells (ESCs), may play role tumorigenesis. Since little is known about the efficacy of Oct4 as potential biomarker for gastric cancer (GC), we investigated its expression GC tissues relationship to various clinicopathological parameters. Methods Primary tumor matching, adjacent non‐cancerous were obtained from 62 patients, was examined by reverse transcription‐PCR (RT‐PCR)...
On the basis of initial success optimization a novel series imidazolopiperazines, second generation compounds involving changes in core piperazine ring was synthesized to improve antimalarial properties. These were carried out further potency and metabolic stability by leveraging outcome set vitro identification studies. The optimized 8,8-dimethyl imidazolopiperazine analogues exhibited improved potency, profile and, as result, enhanced oral exposure vivo mice. found be more efficacious than...
Abstract Background The therapeutic potential of immune checkpoint blockade (ICB) extends across various cancers; however, its effectiveness in treating hepatocellular carcinoma (HCC) is frequently curtailed by both inherent and developed resistance. Objective This research explored the integrating anlotinib (a broad‐spectrum tyrosine kinase inhibitor) with programmed death‐1 (PD‐1) offers mechanistic insights into more effective strategies for HCC. Methods Using patient‐derived organotypic...
Glioma is the most common primary brain tumor in central nervous system (CNS) with high morbidity and mortality adults. Although standardized comprehensive therapy has been adapted, prognosis of glioma patients still frustrating thus novel therapeutic strategies are urgently need. Quercetin (Quer), an important flavonoid compound found many herbs, shown to be effective some models including glioma. Recently, it reported that adequate regulation autophagy can strengthen cytotoxic effect...
A great challenge of cancer chemotherapy is to eliminate cells and concurrently maintain the quality life (QOL) for patients. Previously, we identified a novel anti-cancer bioactive peptide (ACBP), induced in goat spleen or liver following immunization with human gastric protein extract. ACBP alone exhibited anti-tumor activity without measurable side effects. Thus, hypothesize that combined could improve efficacy treatment lead better QOL. In this study, was isolated purified from immunized...
Background/Aims: Glioblastoma multiforme (GBM) is the most malignant primary brain tumor with a poor prognosis. Combination treatment of autophagy inducer and inhibitor may be feasible solution to improve therapeutic effects. However, correlation between them unclear. The purpose this study was investigate effect inhibition at different stages on cytotoxicity inducers in glioblastoma cells. Methods: Autophagy early stage achieved by 3-methyladenine (3-MA) or Beclin 1 shRNA. late chloroquine...
Tetrahydropyrazolo[1,5-a]pyrimidine scaffold was identified as a hit series from Mycobacterium tuberculosis (Mtb) whole cell high through-put screening (HTS) campaign. A of derivatives this class were synthesized to evaluate their structure–activity relationship (SAR) and structure–property (SPR). Compound 9 had promising in vivo DMPK profile mouse exhibited potent activity efficacy model, achieving reduction 3.5 log CFU Mtb after oral administration infected mice once day at 100 mg/kg for...
We tested the hypothesis that circulating tumor cells (CTCs) in preoperative peripheral blood (PPB) and intraoperative pulmonary venous (IPVB) could predict poor long-term survival resected non-small cell lung cancer (NSCLC) patients. CTCs were separated from using magnetic beads coated with antibodies against epithelial-cell adhesion molecule (EpCAM) via magnetic-activated sorting (MACS). quantified fluorescence-labeled pan-cytokeratin through flow cytometry. PPB IPVB 23 consecutive stage...
Abstract Background Hepatocellular carcinoma (HCC) is a common malignant tumor with strong invasiveness and poor prognosis. Previous studies have demonstrated the significant role of USP14 in various solid tumors. However, regulation HCC development progression remains unclear. Methods We discovered through GEO TCGA databases that may play an important liver cancer. Using bioinformatics analysis based on Cancer Genome Atlas (TCGA) database, we screened identified as highly expressed detected...
Gastric cancer has become the second most common malignant tumor in world, revealing molecular mechanism of gastric development is essential for treatment and improvement prognosis. Recent studies have shown that microRNAs may play a carcinogenic or tumor-suppressive role many types cancer. It been detected miR-216b down-regulated types, indicating can be used as prognostic marker these particular However, effect on remains unclear. In present study, miR-216 was observed to significantly...
BACKGROUND The aim of this study was to determine the effects myeloma cells exposed fluid shear stress on osteocytes and osteoclasts, clarify potential underlying mechanisms. MATERIAL AND METHODS A flow a non-flow model were established using chamber. cell line U266 murine osteocytic MLO-Y4 cultured in vitro. osteoclasts examined under microscope. Osteoclasts stained for tartrate-resistant acid phosphatase (TRAP) activity. RANKL osteoprotegerin (OPG) gene expression detected reverse...
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide, with unclear pathogenesis. Sphingomyelin phodiesterase acid-like 3A (SMPDL3A) affects cell differentiation and participates in immune regulation. However, its molecular biological function HCC has not yet been elucidated. Data from 180 patients were analyzed relationship between expression SMPDL3A liver cancer tissues prognosis patients. Crispr-Cas9 dual vector lentivirus was used to knock out lines. The...
MDM2 binding protein (MTBP) has been revealed to be involved in cancer progression and metastasis. However, the role clinical implication of MTBP expression gastric (GC) remains poorly understood. The present study aimed investigate clinicopathological significance prognostic determinant GC. level was examined cancerous matched adjacent noncancerous mucosa tissues by reverse transcription-quantitative polymerase chain reaction western blotting. levels were evaluated immunohistochemical...
The need for novel anti-thyroid cancer (TC) medications is urgent due to the rising incidence and metastatic rates of malignant TC. In this study, we investigated effect Polyphyllin VII (PPVII) TC cells, explored their potential mechanism. B-CPAP TPC-1 were used analyze antitumor activity PPVII by quantifying cell growth metastasis as well study on epithelial mesenchymal transition (EMT). results showed that dramatically reduced capacity cells proliferate migrate in a dose-response manner....
Hepatocellular carcinoma (HCC) is an aggressive form of liver cancer with particularly poor survival rates for patients. Targeted molecular therapies are lacking, and current treatment generally limited to surgical resection or transplantation. Overexpression aberrant signaling the ErbB family receptors has been implicated in HCC, but mechanisms underlying overexpression unclear. In this study, we investigated potential role neuregulin receptor degradation protein-1 (Nrdp1), a regulator...
Cervical esophagogastrostomy is currently the most common method for esophageal reconstruction after esophagectomy. The advantages and disadvantages of hand-sewn, linear-stapled, or circular-stapled anastomoses have been subject to debate in recent years. We explored a new end-to-side anastomosis using circular stapler that embeds remaining tissue into gastric cavity reduce occurrence anastomotic leakage prevent gastroesophageal reflux.In 127 patients with carcinomas, embedding were...
Ubiquitin-related modifier 1 (URM1) is a member of the ubiquitin-like regulator family, which acts as post-translational protein in oxidative emergency response mechanism. Previous studies have shown that URM1 may be involved process apoptosis and play role JNK signaling pathway. In this study, we aimed to investigate possible mechanism HCC progression.Expression was determined 90 pairs matched liver cancer adjacent non-cancerous tissues by immunohistochemistry. The impacts on cell...
Background. Endoplasmic reticulum oxidoreductase 1 alpha (ERO1L) serves as an effector for tumor growth in human malignancies. However, the mechanism of ERO1L on promoting metastasis pancreatic ductal adenocarcinoma (PDAC) remains to be further explored. Methods. Bioinformatics analysis public databases and large-scale metastatic PDAC sequencing was performed determine expression profile prognostic value PDAC. The effect analyzed vitro vivo, via cell biological, molecular, biochemical...
In this study, free porcine hepatocytes suspension (Group A), embedded in collagen gel B), cultured with PLA-O-CMC nanoparticles and C), alone D) were transplanted into peritoneal cavity of ALF rats, respectively. The result showed that plasma HGF levels elevated post-transplantation a peak at 12 hr. rats Group C highest 2, 6, 12, 24 36 hr lowest level 48 Plasma VEGF 72 48, 72, 96 post-transplantation. liver functions recovered most rapidly. Compared B, had significant high Kiel 67 antigen...
Background: Whether repeat surgical resection (RSR) or radiofrequency ablation (RFA) is a better option for recurrent hepatocellular carcinoma (HCC) after primary HCC remains controversial. This study was to investigate the clinical efficacy of RSR versus RFA in treatment at Barcelona Clinic Liver Cancer (BCLC) stage 0/A HCC. Methods: The patients treated by (n=57) (n=51) BCLC Affiliated Hospital Nantong University and Third Second Military Medical from January 2008 March 2018 were...