A5032870666- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Parasitic infections in humans and animals
- Viral-associated cancers and disorders
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Fungal Infections and Studies
- Genomic variations and chromosomal abnormalities
- Gene expression and cancer classification
- Glycosylation and Glycoproteins Research
- Prenatal Screening and Diagnostics
- T-cell and B-cell Immunology
- Blood groups and transfusion
- T-cell and Retrovirus Studies
- Virus-based gene therapy research
- Syphilis Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
- Cancer Immunotherapy and Biomarkers
- Toxoplasma gondii Research Studies
- Bacterial Infections and Vaccines
- Pneumocystis jirovecii pneumonia detection and treatment
- Brain Metastases and Treatment
University of Northampton
2016-2025
Universiti of Malaysia Sabah
2023
Weatherford College
2023
University of Leicester
2008-2022
University of Nottingham
2018
The Open University
2017
Instituto do Câncer do Estado de São Paulo
2010-2012
Universidade de São Paulo
1988-2012
Universidade Federal de Minas Gerais
2010-2012
University of Birmingham
2008-2012
Machine learning approaches are powerful techniques commonly employed for developing cancer prediction models using associated gene expression and mutation data. This manuscript provides a comprehensive review of recent studies that have data from several types (breast, lung, kidney, ovarian, liver, central nervous system gallbladder) survival prediction, tumor identification stratification. We also provide an overview biomarker with these types. The survey captures multiple aspects machine...
There are few studies comparing the capacity of lesion detection conventional MR imaging in neurocysticercosis (NCC). This study was designed to clarify its role evaluation this disease, focusing on total number lesions identified and characterization scolex.MR images from 115 patients were prospectively collected during a 3-year interval, including axial spin-echo (SE) T1-weighted; fast SE T2-weighted; fluid-attenuated inversion recovery (FLAIR); gadolinium-enhanced axial, coronal, sagittal...
<b>Objectives:</b> Neurocysticercosis (NCYST) is the most frequent CNS parasitic disease worldwide, affecting more than 50 million people. However, some of its clinical findings, such as cognitive impairment and dementia, remain poorly characterized, with no controlled studies conducted so far. We investigated frequency profile dementia in a sample patients NCYST comparison cognitively healthy controls (HC) cryptogenic epilepsy (CE). <b>Methods:</b> Forty treatment-naive NCYST, aged 39.25 ±...
Beta-defensins are a family of multifunctional genes with roles in defense against pathogens, reproduction, and pigmentation. In humans, six beta-defensin clustered repeated region which is copy-number variable (CNV) as block, diploid copy number between 1 12. The role host makes the evolutionary history this CNV particularly interesting, because morbidity due to infectious disease likely have been an important selective force human evolution, varied geographical locations. Here, we show...
We report a case of fatal chagasic meningoencephalitis in an AIDS patient. Acute exacerbation chronic Chagas9 disease with involvement the CNS is uncommon and occurs only immunocompromised patients. This third such reported reactivation it underscores importance considering HIV-positive patients from endemic regions.
Cognitive decline related to neurocysticercosis (NC) remains poorly characterized and underdiagnosed. In a cross-sectional study with prospective phase, we evaluated cognitive in patients strictly calcified form (C-NC), the epidemiologically largest subgroup of NC, investigated whether there is spectrum abnormalities disease.Forty treatment-naive C-NC aged 37.6 ± 11.3 years fulfilling criteria for definitive were submitted comprehensive functional evaluation compared 40 active NC (A-NC)...
A DNA vaccine, SCIB1, incorporating two CD8 and CD4 epitopes from TRP-2/gp100 was evaluated in patients with metastatic melanoma. Each patient received SCIB1 via intramuscular injection electroporation. The trial designed to find the safest dose of which induced immune/clinical responses or without tumour. Fifteen tumor doses 0.4-8 mg whilst 20 fully-resected 2–8 doses. Twelve elected continue immunization every 3 months for up 39 months. dose-dependent T cell 88% no serious adverse effects...
<h3>BACKGROUND AND PURPOSE:</h3> Few studies discuss DWI findings in patients with NCC, and their conclusions are variable contradictory. The aim of our study was to describe a cohort emphasizing the frequency reduced diffusion. <h3>MATERIALS METHODS:</h3> This retrospective included 48 NCC. Two neuroradiologists analyzed MR images regarding location, number, stage NCC lesions. On basis visual analysis, they defined, by consensus, presence high signal within lesions on measured ADC values...
AIDS, caused by the retrovirus human immunodeficiency virus (HIV), is leading cause of death economically active people (age, 15-59 years) in sub-Saharan Africa. The host genetic variability immune response to HIV and reconstitution following initiation highly antiretroviral therapy (HAART) poorly understood. Here we focused on copy number variation β-defensin genes, which have been shown anti-HIV activity, are important chemoattractants for Th17 lymphocytes via chemokine receptor CCR6. We...
Abstract Infusing virus-specific T cells is effective treatment for rare Epstein-Barr virus (EBV)–associated posttransplant lymphomas, and more limited success has been reported using this approach to treat a far common EBV-associated malignancy, nasopharyngeal carcinoma (NPC). However, current approaches EBV-transformed lymphoblastoid cell lines reactivate EBV-specific infusion take 2 3 months of in vitro culture favor outgrowth targeting viral antigens expressed within EBV+ but not NPC....
In the pursuit of better cancer classification, many studies have been conducted to identify genes associated with cancer. However, high dimensionality gene expression data and limited relevance a few pose significant challenges this endeavor. Existing selection methods yield divergent lists, further complicating classification process. To overcome issue, we developed novel approach called Fuzzy Gene Selection (FGS), which combines strengths various in field. FGS was using three feature...
Mutation of the Duchenne muscular dystrophy (DMD) gene causes neuromuscular disorders, but increasing evidence has implicated DMD in development and progression several major cancer types. This study investigates prognostic biological significance expression head neck squamous cell carcinoma (HNSCC). Analysis The Cancer Genome Atlas (TCGA) data revealed that high correlates with improved overall (median survival difference: 22 months, p = 0.0083) progression-free (p 0.0237) survival. Dp71ab...
Background: Clinical studies show strong associations between hormone levels, particularly estrogens and the development of skin cancers. Cutaneous melanoma is considered a hormone-related tumour; however, their role in progression remains unclear. Objective: To investigate effects phytoestrogen-rich diet on tumour initiation using syngeneic mouse model. Patients Methods: Mice were fed either or low control injected subcutaneously with 5 × 10⁵ cells (B16-F10). After 10–12 weeks, tumours...