A5028508392- Cancer Immunotherapy and Biomarkers
- Reproductive System and Pregnancy
- Endometrial and Cervical Cancer Treatments
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Cell Image Analysis Techniques
- Single-cell and spatial transcriptomics
- Circular RNAs in diseases
- Cytokine Signaling Pathways and Interactions
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- T-cell and B-cell Immunology
- Cervical Cancer and HPV Research
- Cell Adhesion Molecules Research
Inserm
2021-2025
Sorbonne Université
2021-2024
Centre d'Immunologie et des Maladies Infectieuses
2021-2024
Sanofi (France)
2024
Université Paris 1 Panthéon-Sorbonne
2024
Abstract On one hand, regulatory T cells (Tregs) play an immunosuppressive activity in most solid tumors but not all. the other organization of tumor-infiltrating immune into tertiary lymphoid structures (TLS) is associated with long-term survival cancers. Here, we investigated role Tregs context Non-Small Cell Lung Cancer (NSCLC)-associated TLS. We observed that show a similar profile TLS and non-TLS areas. Autologous inhibit proliferation cytokine secretion CD4 + conventional cells,...
Abstract Cervical tumors are usually treated using surgery, chemotherapy, and radiotherapy, would benefit from immunotherapies. However, the immune microenvironment in cervical cancer remains poorly described. Tertiary lymphoid structures (TLS) were recently described as markers for better immunotherapy response overall prognosis patients. We evaluated tumor microenvironment, specifically focusing on TLS, combined high-throughput phenotyping, soluble factor concentration dosage TME spatial...
<div>Abstract<p>Cervical tumors are usually treated using surgery, chemotherapy, and radiotherapy would benefit from immunotherapies. However, the immune microenvironment in cervical cancer remains poorly described. Tertiary lymphoid structures (TLS) were recently described as markers for better immunotherapy response overall prognosis patients with cancer. We evaluated tumor microenvironment, specifically focusing on TLS, combined high-throughput phenotyping, soluble factor...
<p>Supp. Figure 2: Myeloid cell cluster annotation within cervical tumors.</p>
<p>MFA script</p>
<p>Supplementary Figure 4: Multivariate analysis of cervical cancer patient clinical and TLS parameters.</p>
<p>Supplementary Figure 3: MFA individual parameters and immune cell enrichment-related survival.</p>
<p>Supp. Fig. 1: TLS maturation classification and cell segmentation by multiplex IHC.</p>
Tissue biomarkers that aid in identifying cutaneous melanoma (CM) patients who will benefit from adjuvant immunotherapy are of crucial interest. Metastatic tumor-draining lymph nodes (mTDLN) the first encounter site between metastatic CM cells and an organized immune structure. Therefore, their study may reveal mechanisms could influence patients´ outcomes.Twenty-nine stage-III enrolled clinical trials to vaccine VACCIMEL were included this retrospective study. After radical mTDLN...
Abstract Background Cervical tumors are usually treated using surgery, chemotherapy, and radiotherapy, would benefit from immunotherapies. However, the immune microenvironment in cervical cancer remains poorly described. Tertiary lymphoid structures (TLS) were recently described as markers for better immunotherapy response overall prognosis patients. Methods We integratedly evaluated tumor microenvironment, specifically TLS importance, combined high-throughput phenotyping, soluble factor...