About
Contact & Profiles
A5020042909
Research Areas
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- T-cell and B-cell Immunology
University of Chicago
2022
During B lymphopoiesis, cell progenitors progress through alternating and mutually exclusive stages of clonal expansion immunoglobulin (Ig) gene rearrangements. Great diversity is generated the stochastic recombination Ig segments encoding heavy light chain variable domains. However, this commonly generates autoreactivity. Receptor editing predominant tolerance mechanism for self-reactive cells in bone marrow (BM). receptor rescues autoreactive from negative selection renewed first at
10.1126/sciimmunol.abm1664
article
EN
Science Immunology
2022-08-05
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