A5016655075- Ear Surgery and Otitis Media
- Immune Response and Inflammation
- Pediatric health and respiratory diseases
- Antimicrobial Peptides and Activities
- Otitis Media and Relapsing Polychondritis
- Respiratory and Cough-Related Research
- Hearing Loss and Rehabilitation
- Sinusitis and nasal conditions
- Head and Neck Cancer Studies
- Vestibular and auditory disorders
- Nasal Surgery and Airway Studies
- Head and Neck Surgical Oncology
- Hearing, Cochlea, Tinnitus, Genetics
- Ear and Head Tumors
- Congenital Ear and Nasal Anomalies
- Optical Coherence Tomography Applications
- Bacterial Infections and Vaccines
- Photoacoustic and Ultrasonic Imaging
- Pneumonia and Respiratory Infections
- Salivary Gland Tumors Diagnosis and Treatment
- Noise Effects and Management
- Head and Neck Anomalies
- Asthma and respiratory diseases
- Hearing Impairment and Communication
- NF-κB Signaling Pathways
University of Lübeck
2015-2025
University Hospital Schleswig-Holstein
2020-2025
Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde
2018-2024
Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde
2021-2022
Universitäres Kinderwunschzentrum Lübeck
2022
Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde
2020
University Medical Center
2020
University of California, San Diego
2008-2019
University Hospital Ulm
2018
Universitäts-HNO-Klinik Heidelberg
2018
Otitis media is the most prevalent childhood disease in developed countries. The involvement of Toll-like receptors (TLRs) otitis pathophysiology has been implicated by studies cell lines and association TLR gene polymorphisms. However, precise functions TLRs etiology vivo have not examined. We investigated inflammatory response to nontypeable Haemophilus influenzae using a model wild-type, TLR2(- /-) TLR4(-/ -) mice microarray, qPCR, immunohistochemistry, Western blot analysis...
Otitis media is the most common disease of childhood, and represents an important health challenge to 10-15% children who experience chronic/recurrent middle ear infections. The undergoes extensive modifications during otitis media, potentially involving changes in expression many genes. Expression profiling offers opportunity discover novel genes pathways involved this childhood disease. ears 320 WBxB6 F1 hybrid mice were inoculated with non-typeable Haemophilus influenzae (NTHi) or PBS...
A number of diseases the middle ear are summed up under term otitis media: acute media, recurrent media with effusion, chronic suppurative and epitympanalis (= cholesteatoma). Acute belongs to most common pediatric is often caused by bacterial infection. Since advent pneumococcal vaccines quantity AOM pneumococci has declined; vaccination against NTHi Moraxella catarrhalis being developed. Main pillar conservative treatment symptomatic therapy otalgia fever as well restoring Eustachian tubal...
Signaling defects in the Toll-like receptor (TLR) pathway, such as interleukin-1 receptor-associated kinase 4 deficiency, highlight prominence of TLR signaling defense against bacterial disease. Because myeloid differentiation primary response gene 88 (MyD88) can transduce signals from almost all TLRs, we studied its role otitis media (OM), most common upper respiratory tract infectious disease young children.The middle ears (MEs) wild-type (WT) and MyD88(-/-) mice were inoculated with...
In the imaging of airway tissue, optical coherence tomography (OCT) provides cross-sectional images tissue structures, shows cilia movement and mucus secretion, but does not provide sufficient contrast to differentiate individual cells. By using fast sequences microscopic resolution OCT (mOCT) images, can use small signal fluctuations overcome lack in speckle noise. this way, visualizes morphology on a cellular level allows tracking dynamic behavior immune cells, as well transport secretion....
Chronic Otitis Media (COM) is defined as long term inflammation and colonization with pathogenic bacteria due to a defect or retraction of the tympanic membrane. Surgical interventions are often augmented by antibiotic resistance development therefore, off-label treatment using natural drug 1,8-Cineol was carried out. All COM patients underwent therapy middle ear surgery developed resistances. Microbiological investigations from auditory canal stool samples were performed in correlation...
Otitis media (OM), a common infectious disease in children, is associated with bacterial middle ear (ME) infection. Toll-like receptors (TLRs) are important mediators of innate immune responses, and TLR9 specifically recognizes the unmethylated cytidine-phosphate-guanosine (CpG) motifs DNA. Additional sensors foreign DNA have recently been identified. The role sensing was investigated murine model OM induced by non-typeable Haemophilus influenzae (NTHi). Expression genes related to...
Background Cholesteatoma is a gradually expanding destructive epithelial lesion within the middle ear. It can cause extensive local tissue destruction in temporal bone and initially lead to development of conductive hearing loss via ossicular erosion. As disease progresses, sensorineural loss, vertigo or facial palsy may occur. promote spread infection through tegmen ear meningitis intracranial infections with abscess formation. must, therefore, be considered as potentially life-threatening...
Abstract The human auditory system must distinguish relevant sounds from noise. Severe hearing loss can be treated with cochlear implants (CIs), but how the brain adapts to electrical remains unclear. This study examined adaptation unilateral CI use in first and seventh month after CI-activation using speech comprehension measures EEG recordings, both during passive listening an active spatial task. We here provide electrophysiological evidence for a longitudinal increase temporal coding...
Abstract 1,8-Cineol is a natural plant-based therapeutic agent and commonly used to treat broad range of acute chronic airway inflammatory diseases. has recently been shown attenuate the checkpoint molecule PDL-1 in circulating monocytes patients with Otitis media (OM) was associated an improved clinical outcome. Hypoxia-inducible factor (HIF) thought play essential role middle ear process, mainly due dysfunctions eustachian tube. However, unambiguous impact on hypoxia-driven immune...
Innate immune mechanisms are crucial in defense against bacterial illnesses humans, as evidenced by abnormal antibacterial responses due to defects TLR signaling, seen children with MyD88 or IL-1R-associated kinase 4 deficiency. Otitis media (OM) is the most common disease of childhood, and role innate molecules this disorder remains unclear. In a murine model OM, we show that, absence TNF, key effector immunity, prolonged after middle ear infection nontypeable Haemophilus influenzae (NTHi)....
Abstract Background Toll-like receptor (TLR) signalling is crucial for innate immune responses to infection. The involvement of TLRs in otitis media (OM), the most prevalent childhood disease developed countries, has been implicated by studies middle ear cell lines, association TLR-related gene polymorphisms, and altered OM mice bearing mutations TLR genes. Activated signal via two alternative intracellular signaling molecules with differing effects; MyD88 (Myeloid differentiation primary...
Patients with otitis media (OM) encounter significant functional hearing impairment conductive, or a combined loss and long-term sequelae involving impaired speech/language development in children, reduced academic achievement irreversible disorders of middle inner ear requiring long time therapy and/or multiple surgeries. In its persistent chronic form, Otitis (COM) can often only be treated by undergoing surgery for restoration. The inflammatory reaction plays major role, caused...
Abstract Background Tumor necrosis factor (TNFA) is the canonical member of TNF superfamily, which plays a major role in both inflammation and apoptosis. To evaluate TNFs otitis media (OM), most common disease childhood, we evaluated middle ear (ME) expression genes encoding receptor superfamilies during bacterial OM mouse, characterized TNFA-deficient mice, assessed apoptosis normal versus TNF-deficient MEs. Results receptors were broadly regulated OM, with TNFA showing highest level...
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common inflammatory disease causing considerable burden. The anti-inflammatory monoterpene 1,8-Cineol natural plant-based therapeutic agent that well established to treat chronic and acute airway diseases. Aim of this study was investigate whether the herbal drug reaches tissue via gut blood stream upon its oral administration. A highly sensitive gas chromatography mass spectrometry-based method stir bar sorptive extraction (SBSE) for...
Background . Cholesteatoma is a destructive process of the middle ear resulting in erosion surrounding bony structures with consequent hearing loss, vestibular dysfunction, facial paralysis, or intracranial complications. The etiopathogenesis cholesteatoma controversial but associated recurrent infections. role intracellular innate immune receptors, NOD-like and their signaling networks was investigated cholesteatoma, since mutations receptor-related genes have been implicated other chronic...